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データを開く
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基本情報
登録情報 | データベース: PDB / ID: 1tlm | ||||||
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タイトル | STRUCTURAL ASPECTS OF INOTROPIC BIPYRIDINE BINDING: CRYSTAL STRUCTURE DETERMINATION TO 1.9 ANGSTROMS OF THE HUMAN SERUM TRANSTHYRETIN-MILRINONE COMPLEX | ||||||
![]() | TRANSTHYRETIN | ||||||
![]() | TRANSPORT(THYROXINE) | ||||||
機能・相同性 | ![]() Retinoid cycle disease events / The canonical retinoid cycle in rods (twilight vision) / thyroid hormone binding / purine nucleobase metabolic process / Non-integrin membrane-ECM interactions / Retinoid metabolism and transport / hormone activity / azurophil granule lumen / Amyloid fiber formation / Neutrophil degranulation ...Retinoid cycle disease events / The canonical retinoid cycle in rods (twilight vision) / thyroid hormone binding / purine nucleobase metabolic process / Non-integrin membrane-ECM interactions / Retinoid metabolism and transport / hormone activity / azurophil granule lumen / Amyloid fiber formation / Neutrophil degranulation / extracellular space / extracellular exosome / extracellular region / identical protein binding 類似検索 - 分子機能 | ||||||
生物種 | ![]() | ||||||
手法 | ![]() | ||||||
![]() | Wojtczak, A. / Luft, J. / Cody, V. | ||||||
![]() | ![]() タイトル: Structural aspects of inotropic bipyridine binding. Crystal structure determination to 1.9 A of the human serum transthyretin-milrinone complex. 著者: Wojtczak, A. / Luft, J.R. / Cody, V. #1: ![]() タイトル: Mechanism of Molecular Recognition. Structural Aspects of 3,3'-Diiodo-L-Thyronine Binding to Human Serum Transthyretin 著者: Wojtczak, A. / Luft, J. / Cody, V. #2: ![]() タイトル: Crystal Structure Determination at 2.3 Angstroms Resolution of Human Transthyretin-3', 5'-Dibromo-2',4,4',6-Tetrahydroxyaurone Complex 著者: Ciszak, E. / Cody, V. / Luft, J.R. #3: ![]() タイトル: Protein-DNA and Protein-Hormone Interactions in Prealbumin, a Model of the Thyroid Hormone Nuclear Receptor (Query) 著者: Blake, C.C.F. / Oatley, S.J. #6: ![]() タイトル: Structure of Human Plasma Prealbumin at 2.5 Angstroms Resolution, a Preliminary Report on the Polypeptide Chain Conformation, Quaternary Structure and Thyroxine Binding 著者: Blake, C.C.F. / Geisow, M.J. / Swan, I.D.A. / Rerat, C. / Rerat, B. #7: ![]() タイトル: An X-Ray Study of the Subunit Structure of Prealbumin 著者: Blake, C.C.F. / Swan, I.D.A. / Rerat, C. / Berthou, J. / Laurent, A. / Rerat, B. | ||||||
履歴 |
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Remark 700 | SHEET THE FIRST STRAND OF THE *EXTERNAL* SHEET IN EACH SUBUNIT IS DISCONTINUOUS. TO ACCOMMODATE ...SHEET THE FIRST STRAND OF THE *EXTERNAL* SHEET IN EACH SUBUNIT IS DISCONTINUOUS. TO ACCOMMODATE THESE DISCONTINUITIES EACH *EXTERNAL* SHEET IS REPRESENTED HERE TWICE, WITH A DIFFERENT STRAND 1 IN EACH CASE. STRANDS 2, 3, 4 OF *X1A* ARE IDENTICAL TO STRANDS 2, 3, 4 OF *X2A*. SIMILARLY STRANDS 2, 3, 4 OF *X1B* ARE IDENTICAL TO STRANDS 2, 3, 4 OF *X2B*. THIS DESCRIPTION IS CONSISTENT WITH THAT USED BY BLAKE AND COWORKERS FOR THE NATIVE TRANSTHYRETIN PROTEIN DATA BANK ENTRY 2PAB. |
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構造の表示
構造ビューア | 分子: ![]() ![]() |
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ダウンロードとリンク
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ダウンロード
PDBx/mmCIF形式 | ![]() | 64 KB | 表示 | ![]() |
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PDB形式 | ![]() | 47.4 KB | 表示 | ![]() |
PDBx/mmJSON形式 | ![]() | ツリー表示 | ![]() | |
その他 | ![]() |
-検証レポート
文書・要旨 | ![]() | 396.1 KB | 表示 | ![]() |
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文書・詳細版 | ![]() | 413.6 KB | 表示 | |
XML形式データ | ![]() | 9.6 KB | 表示 | |
CIF形式データ | ![]() | 13.5 KB | 表示 | |
アーカイブディレクトリ | ![]() ![]() | HTTPS FTP |
-関連構造データ
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リンク
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集合体
登録構造単位 | ![]()
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単位格子 |
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Components on special symmetry positions |
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要素
#1: タンパク質 | 分子量: 13776.376 Da / 分子数: 2 / 由来タイプ: 組換発現 / 由来: (組換発現) ![]() #2: 化合物 | #3: 水 | ChemComp-HOH / | 配列の詳細 | SEQUENCE ADVISORY NOTICE: DIFFERENCE BETWEEN SWISS-PROT AND PDB SEQUENCE. SWISS-PROT ENTRY NAME: ...SEQUENCE ADVISORY NOTICE: DIFFERENCE | |
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-実験情報
-実験
実験 | 手法: ![]() |
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試料調製
結晶 | マシュー密度: 2.29 Å3/Da / 溶媒含有率: 46.32 % | ||||||||||||||||||||
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結晶化 | *PLUS 温度: 293 K / pH: 6.9 / 手法: 蒸気拡散法, ハンギングドロップ法 | ||||||||||||||||||||
溶液の組成 | *PLUS
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-データ収集
反射 | *PLUS 最高解像度: 1.89 Å / Num. obs: 16482 / % possible obs: 79 % / Num. measured all: 46029 / Rmerge(I) obs: 0.06 |
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反射 シェル | *PLUS 最高解像度: 1.89 Å / 最低解像度: 2.01 Å / % possible obs: 36 % |
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解析
ソフトウェア | 名称: PROLSQ / 分類: 精密化 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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精密化 | 解像度: 1.9→8 Å 詳細: THIS COORDINATE SET COMPRISES TWO CHAINS REPRESENTING TWO CHEMICALLY EQUIVALENT, BUT CRYSTALLOGRAPHICALLY DISTINCT, ENTITIES. THE OTHER HALF OF THE COMPLETE TETRAMER MAY BE GENERATED FROM ...詳細: THIS COORDINATE SET COMPRISES TWO CHAINS REPRESENTING TWO CHEMICALLY EQUIVALENT, BUT CRYSTALLOGRAPHICALLY DISTINCT, ENTITIES. THE OTHER HALF OF THE COMPLETE TETRAMER MAY BE GENERATED FROM THIS DIMER BY THE APPLICATION OF THE CRYSTALLOGRAPHIC DIAD PARALLEL TO Z THROUGH THE ORIGIN OF THIS COORDINATE SYSTEM, I. E. XPRIME=-X, YPRIME=-Y, ZPRIME=Z.
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精密化ステップ | サイクル: LAST / 解像度: 1.9→8 Å
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拘束条件 |
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ソフトウェア | *PLUS 名称: PROLSQ / 分類: refinement | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
精密化 | *PLUS 最高解像度: 1.9 Å / 最低解像度: 8 Å / Num. reflection obs: 16162 / σ(F): 2 / Rfactor obs: 0.173 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
溶媒の処理 | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
原子変位パラメータ | *PLUS |