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- PDB-1tch: STRUCTURE-ACTIVITY RELATIONSHIPS OF MU-CONOTOXIN GIIIA: STRUCTURE... -

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Basic information

Entry
Database: PDB / ID: 1tch
TitleSTRUCTURE-ACTIVITY RELATIONSHIPS OF MU-CONOTOXIN GIIIA: STRUCTURE DETERMINATION OF ACTIVE AND INACTIVE SODIUM CHANNEL BLOCKER PEPTIDES BY NMR AND SIMULATED ANNEALING CALCULATIONS
ComponentsMU-CONOTOXIN GIIIA
KeywordsNEUROTOXIN
Function / homologyMu-Conotoxin / Conotoxin, mu-type / Mu-conotoxin family signature. / sodium channel inhibitor activity / toxin activity / extracellular region / Mu-conotoxin GIIIA
Function and homology information
MethodSOLUTION NMR
AuthorsLancelin, J.-M. / Kohda, D. / Inagaki, F.
Citation
Journal: Biochemistry / Year: 1992
Title: Structure-activity relationships of mu-conotoxin GIIIA: structure determination of active and inactive sodium channel blocker peptides by NMR and simulated annealing calculations.
Authors: Wakamatsu, K. / Kohda, D. / Hatanaka, H. / Lancelin, J.M. / Ishida, Y. / Oya, M. / Nakamura, H. / Inagaki, F. / Sato, K.
#1: Journal: Biochemistry / Year: 1991
Title: Tertiary Structure of Conotoxin Giiia in Aqueous Solution
Authors: Lancelin, J.-M. / Kohda, D. / Tate, S.-I. / Yanagawa, Y. / Abe, T. / Satake, M. / Inagaki, F.
#2: Journal: J.Biol.Chem. / Year: 1991
Title: Active Site of Mu-Conotoxin Giiia, a Peptide Blocker of Muscle Sodium Channels
Authors: Sato, K. / Ishida, Y. / Wakamatsu, K. / Kato, R. / Honda, H. / Ohizumi, Y. / Nakamura, H. / Ohya, M. / Lancelin, J.-M. / Kohda, D. / Inagaki, F.
History
DepositionDec 12, 1992Processing site: BNL
Revision 1.0Jan 31, 1994Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Nov 29, 2017Group: Derived calculations / Other
Category: pdbx_database_status / pdbx_struct_assembly ...pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list / struct_conf
Item: _pdbx_database_status.process_site
Revision 1.4Mar 26, 2025Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Structure summary
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_entry_details / pdbx_modification_feature / struct_conn / struct_ref_seq_dif / struct_site
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Assembly

Deposited unit
A: MU-CONOTOXIN GIIIA


Theoretical massNumber of molelcules
Total (without water)2,5351
Polymers2,5351
Non-polymers00
Water00
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_5551
Atom site foot note1: RESIDUE HYP 7 IS A CIS HYDROXYPROLINE. / 2: THE C-TERMINAL CARBOXYLATE IS AMIDATED.
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)1 / -
Representative

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Components

#1: Protein/peptide MU-CONOTOXIN GIIIA


Mass: 2535.023 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
References: UniProt: P01523
Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Sample preparation

Crystal grow
*PLUS
Method: other / Details: NMR

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Processing

NMR softwareName: X-PLOR / Version: 2.1 / Developer: BRUNGER / Classification: refinement
NMR ensembleConformers submitted total number: 1

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