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- PDB-1srb: CONFORMATIONAL STUDIES ON SRTB, A NON-SELECTIVE ENDOTHELIN RECEPT... -

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Entry
Database: PDB / ID: 1srb
TitleCONFORMATIONAL STUDIES ON SRTB, A NON-SELECTIVE ENDOTHELIN RECEPTOR AGONIST, AND ON IRL 1620, AN ETB RECEPTOR SPECIFIC AGONIST
ComponentsSarafotoxins precursor
KeywordsTOXIN
Function / homology
Function and homology information


endothelin B receptor binding / vein smooth muscle contraction / regulation of systemic arterial blood pressure by endothelin / regulation of vasoconstriction / hormone activity / intracellular calcium ion homeostasis / toxin activity / extracellular space
Similarity search - Function
Endothelin-like toxin / Endothelin-like toxin, conserved site / Endothelin / Endothelin family / Endothelin family signature. / Endothelin
Similarity search - Domain/homology
Biological speciesAtractaspis microlepidota andersoni (Arabian small-scaled burrowing asp)
MethodSOLUTION NMR
AuthorsSmith, R. / Atkins, A.R.
Citation
Journal: Biochemistry / Year: 1995
Title: 1H NMR studies of sarafotoxin SRTb, a nonselective endothelin receptor agonist, and IRL 1620, an ETB receptor-specific agonist.
Authors: Atkins, A.R. / Martin, R.C. / Smith, R.
#1: Journal: FEBS Lett. / Year: 1991
Title: Conformation of Sarafotoxin-6B in Aqueous Solution Determined by NMR Spectroscopy and Distance Geometry
Authors: Mills, R.G. / Atkins, A.R. / Harvey, T. / Junius, F.K. / Smith, R. / King, G.F.
History
DepositionSep 6, 1994Processing site: BNL
Revision 1.0Nov 1, 1994Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Mar 2, 2022Group: Database references / Derived calculations / Other
Category: database_2 / pdbx_database_status ...database_2 / pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.process_site
Revision 1.4Oct 23, 2024Group: Data collection / Structure summary
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / pdbx_entry_details / pdbx_modification_feature

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Assembly

Deposited unit
A: Sarafotoxins precursor


Theoretical massNumber of molelcules
Total (without water)2,5711
Polymers2,5711
Non-polymers00
Water00
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)10 / -
Representative

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Components

#1: Protein/peptide Sarafotoxins precursor


Mass: 2570.980 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Atractaspis microlepidota andersoni (Arabian small-scaled burrowing asp)
Species: Atractaspis microlepidota / Strain: andersoni / References: UniProt: P13208
Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Processing

Software
NameClassification
X-PLORmodel building
X-PLORrefinement
X-PLORphasing
NMR softwareName: X-PLOR / Developer: BRUNGER / Classification: refinement
NMR ensembleConformers submitted total number: 10

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