登録情報 | データベース: PDB / ID: 1sd1 |
---|
タイトル | STRUCTURE OF HUMAN 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE COMPLEXED WITH FORMYCIN A |
---|
要素 | 5'-methylthioadenosine phosphorylase |
---|
キーワード | TRANSFERASE / METHYLTHIOADENOSINE PHOSPHORYLASE / PURINE NUCLEOSIDE PHOSPHORYLASE / PURINE SALVAGE / FORMYCIN A |
---|
機能・相同性 | 機能・相同性情報
Methionine salvage pathway / S-methyl-5'-thioadenosine phosphorylase / 1,4-alpha-oligoglucan phosphorylase activity / S-methyl-5-thioadenosine phosphorylase activity / L-methionine salvage from methylthioadenosine / nucleobase-containing compound metabolic process / purine ribonucleoside salvage / response to testosterone / Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation / methylation ...Methionine salvage pathway / S-methyl-5'-thioadenosine phosphorylase / 1,4-alpha-oligoglucan phosphorylase activity / S-methyl-5-thioadenosine phosphorylase activity / L-methionine salvage from methylthioadenosine / nucleobase-containing compound metabolic process / purine ribonucleoside salvage / response to testosterone / Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation / methylation / extracellular exosome / nucleoplasm / cytosol類似検索 - 分子機能 Methylthioadenosine phosphorylase (MTAP) / Purine phosphorylase, family 2, conserved site / Purine and other phosphorylases family 2 signature. / Nucleoside phosphorylase domain / Nucleoside phosphorylase domain / Phosphorylase superfamily / Nucleoside phosphorylase superfamily / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 Chem-FMC / S-methyl-5'-thioadenosine phosphorylase類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.03 Å |
---|
データ登録者 | Lee, J.E. / Settembre, E.C. / Cornell, K.A. / Riscoe, M.K. / Sufrin, J.R. / Ealick, S.E. / Howell, P.L. |
---|
引用 | ジャーナル: Biochemistry / 年: 2004 タイトル: Structural Comparison of MTA Phosphorylase and MTA/AdoHcy Nucleosidase Explains Substrate Preferences and Identifies Regions Exploitable for Inhibitor Design. 著者: Lee, J.E. / Settembre, E.C. / Cornell, K.A. / Riscoe, M.K. / Sufrin, J.R. / Ealick, S.E. / Howell, P.L. |
---|
履歴 | 登録 | 2004年2月12日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2004年5月18日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2008年4月29日 | Group: Version format compliance |
---|
改定 1.2 | 2011年7月13日 | Group: Derived calculations / Version format compliance |
---|
改定 1.3 | 2017年10月11日 | Group: Refinement description / カテゴリ: software |
---|
改定 1.4 | 2024年2月14日 | Group: Data collection / Database references / Derived calculations カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
---|
|
---|
Remark 999 | SEQUENCE The I -> V conflict for residue 56 is noted in Swiss-Prot entry Q13126. |
---|