[English] 日本語
Yorodumi- PDB-1rod: CHIMERIC PROTEIN OF INTERLEUKIN 8 AND HUMAN MELANOMA GROWTH STIMU... -
+Open data
-Basic information
Entry | Database: PDB / ID: 1rod | ||||||
---|---|---|---|---|---|---|---|
Title | CHIMERIC PROTEIN OF INTERLEUKIN 8 AND HUMAN MELANOMA GROWTH STIMULATING ACTIVITY PROTEIN, NMR | ||||||
Components | CHIMERIC PROTEIN OF INTERLEUKIN 8 AND HUMAN MELANOMA GROWTH STIMULATING ACTIVITY PROTEIN | ||||||
Keywords | CHEMOKINE / CYTOKINE / CHEMOTAXIS / INFLAMMATORY RESPONSE | ||||||
Function / homology | Function and homology information regulation of single stranded viral RNA replication via double stranded DNA intermediate / regulation of entry of bacterium into host cell / interleukin-8 receptor binding / positive regulation of cellular biosynthetic process / negative regulation of cell adhesion molecule production / ATF4 activates genes in response to endoplasmic reticulum stress / CXCR chemokine receptor binding / embryonic digestive tract development / neutrophil activation / induction of positive chemotaxis ...regulation of single stranded viral RNA replication via double stranded DNA intermediate / regulation of entry of bacterium into host cell / interleukin-8 receptor binding / positive regulation of cellular biosynthetic process / negative regulation of cell adhesion molecule production / ATF4 activates genes in response to endoplasmic reticulum stress / CXCR chemokine receptor binding / embryonic digestive tract development / neutrophil activation / induction of positive chemotaxis / cellular response to fibroblast growth factor stimulus / chemokine-mediated signaling pathway / positive regulation of neutrophil chemotaxis / Chemokine receptors bind chemokines / chemokine activity / negative regulation of G protein-coupled receptor signaling pathway / Interleukin-10 signaling / cellular response to interleukin-1 / regulation of cell adhesion / neutrophil chemotaxis / response to endoplasmic reticulum stress / Peptide ligand-binding receptors / calcium-mediated signaling / response to molecule of bacterial origin / receptor internalization / positive regulation of angiogenesis / chemotaxis / antimicrobial humoral immune response mediated by antimicrobial peptide / Senescence-Associated Secretory Phenotype (SASP) / cellular response to tumor necrosis factor / heparin binding / G alpha (i) signalling events / cellular response to lipopolysaccharide / Interleukin-4 and Interleukin-13 signaling / angiogenesis / intracellular signal transduction / inflammatory response / G protein-coupled receptor signaling pathway / negative regulation of cell population proliferation / negative regulation of gene expression / positive regulation of gene expression / signal transduction / extracellular space / extracellular region Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | SOLUTION NMR | ||||||
Authors | Roesch, P. / Sticht, H. / Auer, M. / Schmitt, B. / Besemer, J. / Horcher, M. / Kirsch, T. / Lindley, I.J.D. | ||||||
Citation | Journal: Eur.J.Biochem. / Year: 1996 Title: Structure and activity of a chimeric interleukin-8-melanoma-growth-stimulatory-activity protein. Authors: Sticht, H. / Auer, M. / Schmitt, B. / Besemer, J. / Horcher, M. / Kirsch, T. / Lindley, I.J. / Rosch, P. | ||||||
History |
|
-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
---|
-Downloads & links
-Download
PDBx/mmCIF format | 1rod.cif.gz | 366 KB | Display | PDBx/mmCIF format |
---|---|---|---|---|
PDB format | pdb1rod.ent.gz | 315.9 KB | Display | PDB format |
PDBx/mmJSON format | 1rod.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 1rod_validation.pdf.gz | 364 KB | Display | wwPDB validaton report |
---|---|---|---|---|
Full document | 1rod_full_validation.pdf.gz | 531.8 KB | Display | |
Data in XML | 1rod_validation.xml.gz | 50.9 KB | Display | |
Data in CIF | 1rod_validation.cif.gz | 67.2 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/ro/1rod ftp://data.pdbj.org/pub/pdb/validation_reports/ro/1rod | HTTPS FTP |
-Related structure data
Similar structure data |
---|
-Links
-Assembly
Deposited unit |
| |||||||||
---|---|---|---|---|---|---|---|---|---|---|
1 |
| |||||||||
NMR ensembles |
|
-Components
#1: Protein | Mass: 8155.622 Da / Num. of mol.: 2 Fragment: INTERLEUKIN 8 RESIDUES 1 - 53, HUMAN MELANOMA GROWTH STIMULATING ACTIVITY PROTEIN RESIDUES 54 - 72 Source method: isolated from a genetically manipulated source Details: DIMERIC PROTEIN / Source: (gene. exp.) Homo sapiens (human) / Fragment: RESIDUES 54 - 72 / Gene: POTENTIAL / Production host: Escherichia coli (E. coli) / References: UniProt: P10145 |
---|
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
---|
-Sample preparation
Crystal grow | *PLUS Method: other |
---|
-Processing
Software |
| ||||||||
---|---|---|---|---|---|---|---|---|---|
NMR software | Name: X-PLOR / Developer: BRUNGER / Classification: refinement | ||||||||
NMR ensemble | Conformers submitted total number: 8 |