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Open data
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Basic information
Entry | Database: PDB / ID: 1rlb | ||||||
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Title | RETINOL BINDING PROTEIN COMPLEXED WITH TRANSTHYRETIN | ||||||
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![]() | COMPLEX (PROTEIN/PROTEIN) / COMPLEX (PROTEIN-PROTEIN) / COMPLEX (PROTEIN-PROTEIN) complex | ||||||
Function / homology | ![]() Retinoid metabolism disease events / urinary bladder development / embryonic retina morphogenesis in camera-type eye / retinol transport / female genitalia morphogenesis / retinol transmembrane transporter activity / embryonic organ morphogenesis / maintenance of gastrointestinal epithelium / embryonic skeletal system development / negative regulation of cardiac muscle cell proliferation ...Retinoid metabolism disease events / urinary bladder development / embryonic retina morphogenesis in camera-type eye / retinol transport / female genitalia morphogenesis / retinol transmembrane transporter activity / embryonic organ morphogenesis / maintenance of gastrointestinal epithelium / embryonic skeletal system development / negative regulation of cardiac muscle cell proliferation / eye development / heart trabecula formation / retinal binding / cardiac muscle tissue development / retinol metabolic process / retinol binding / positive regulation of immunoglobulin production / Retinoid cycle disease events / The canonical retinoid cycle in rods (twilight vision) / thyroid hormone binding / uterus development / vagina development / purine nucleobase metabolic process / Non-integrin membrane-ECM interactions / response to retinoic acid / Retinoid metabolism and transport / visual perception / gluconeogenesis / lung development / positive regulation of insulin secretion / hormone activity / azurophil granule lumen / glucose homeostasis / heart development / Amyloid fiber formation / Neutrophil degranulation / extracellular space / extracellular exosome / extracellular region / identical protein binding Similarity search - Function | ||||||
Biological species | ![]() ![]() ![]() | ||||||
Method | ![]() | ||||||
![]() | Monaco, H.L. / Rizzi, M. / Coda, A. | ||||||
![]() | ![]() Title: Structure of a complex of two plasma proteins: transthyretin and retinol-binding protein. Authors: Monaco, H.L. / Rizzi, M. / Coda, A. #1: ![]() Title: Crystallization of the Macromolecular Complex Transthyretin Retinol Binding Protein Authors: Monaco, H.L. / Mancia, F. / Rizzi, M. / Coda, A. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 159.9 KB | Display | ![]() |
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PDB format | ![]() | 128.3 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 505.2 KB | Display | ![]() |
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Full document | ![]() | 570.2 KB | Display | |
Data in XML | ![]() | 26.9 KB | Display | |
Data in CIF | ![]() | 37.8 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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1 |
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Unit cell |
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Components
#1: Protein | Mass: 13776.376 Da / Num. of mol.: 4 / Source method: isolated from a natural source / Source: (natural) ![]() #2: Protein | Mass: 20079.545 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) ![]() ![]() #3: Chemical | |
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-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 2.65 Å3/Da / Density % sol: 53.5 % | |||||||||||||||||||||||||
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Crystal | *PLUS Density % sol: 53.5 % | |||||||||||||||||||||||||
Crystal grow | *PLUS Temperature: 4 ℃ / pH: 5.5 / Method: microdialysis | |||||||||||||||||||||||||
Components of the solutions | *PLUS
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-Data collection
Diffraction source | Wavelength: 1.5418 Å |
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Detector | Type: RIGAKU / Detector: IMAGE PLATE |
Radiation | Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength: 1.5418 Å / Relative weight: 1 |
Reflection | Num. obs: 17465 / % possible obs: 94.8 % / Observed criterion σ(I): 0 / Redundancy: 2.7 % / Rmerge(I) obs: 0.09 |
Reflection | *PLUS Highest resolution: 3.1 Å / Lowest resolution: 6 Å / Num. measured all: 47491 / Rmerge(I) obs: 0.09 |
Reflection shell | *PLUS Highest resolution: 3.1 Å / Lowest resolution: 3.3 Å / % possible obs: 83.2 % / Num. unique obs: 2359 |
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Processing
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Refinement | Resolution: 3.1→6 Å / σ(F): 0 Details: THERE IS CLOSE CONTACT BETWEEN RESIDUE GLU D 66 AND A SYMMETRY-RELATED COPY OF ITSELF.
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Refinement step | Cycle: LAST / Resolution: 3.1→6 Å
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Refine LS restraints |
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Software | *PLUS Name: ![]() | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refinement | *PLUS Rfactor Rwork: 0.201 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Solvent computation | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Displacement parameters | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refine LS restraints | *PLUS Type: x_dihedral_angle_deg / Dev ideal: 26.7 |