- PDB-1rfh: Solution structure of the C1 domain of Nore1, a novel Ras effector -
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基本情報
登録情報
データベース: PDB / ID: 1rfh
タイトル
Solution structure of the C1 domain of Nore1, a novel Ras effector
要素
Ras association (RalGDS/AF-6) domain family 5
キーワード
METAL BINDING PROTEIN / ZINC / SIGNAL TRANSDUCTION / APOPTOSIS / CYSTEINE RICH DOMAIN
機能・相同性
機能・相同性情報
small GTPase binding => GO:0031267 / negative regulation of lymphocyte proliferation / lymphocyte proliferation / regulation of protein localization to nucleus / positive regulation of protein ubiquitination / regulation of apoptotic process / microtubule / intracellular signal transduction / negative regulation of cell population proliferation / apoptotic process ...small GTPase binding => GO:0031267 / negative regulation of lymphocyte proliferation / lymphocyte proliferation / regulation of protein localization to nucleus / positive regulation of protein ubiquitination / regulation of apoptotic process / microtubule / intracellular signal transduction / negative regulation of cell population proliferation / apoptotic process / signal transduction / identical protein binding / nucleus / metal ion binding / cytoplasm 類似検索 - 分子機能
Ras association domain-containing protein 5 / Ras association domain-containing protein 1-6 / Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain / SARAH domain / SARAH domain profile. / Wheat Germ Agglutinin (Isolectin 2); domain 1 - #20 / Ras association (RalGDS/AF-6) domain / Ras-associating (RA) domain profile. / Ras association (RalGDS/AF-6) domain / Ras-associating (RA) domain ...Ras association domain-containing protein 5 / Ras association domain-containing protein 1-6 / Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain / SARAH domain / SARAH domain profile. / Wheat Germ Agglutinin (Isolectin 2); domain 1 - #20 / Ras association (RalGDS/AF-6) domain / Ras-associating (RA) domain profile. / Ras association (RalGDS/AF-6) domain / Ras-associating (RA) domain / Wheat Germ Agglutinin (Isolectin 2); domain 1 / Phorbol esters/diacylglycerol binding domain (C1 domain) / Zinc finger phorbol-ester/DAG-type signature. / Zinc finger phorbol-ester/DAG-type profile. / Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) / Protein kinase C-like, phorbol ester/diacylglycerol-binding domain / C1-like domain superfamily / Ubiquitin-like domain superfamily / 2-Layer Sandwich / Alpha Beta 類似検索 - ドメイン・相同性
Ras association domain-containing protein 5 / Ras association domain-containing protein 5 類似検索 - 構成要素
手法: simulated annealing torsion angle dynamics / ソフトェア番号: 1 詳細: the structures are based on a total of 557 restraints, 475 are NOE-derived distance constraints, 48 dihedral angle restraints, 34 distance restraints from hydrogen bonds.
代表構造
選択基準: minimized average structure
NMRアンサンブル
コンフォーマー選択の基準: structures with the least restraint violations,structures with the lowest energy 計算したコンフォーマーの数: 50 / 登録したコンフォーマーの数: 21