登録情報 | データベース: PDB / ID: 1r8u |
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タイトル | NMR structure of CBP TAZ1/CITED2 complex |
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要素 | - CREB-binding protein
- Cbp/p300-interacting transactivator 2
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キーワード | TRANSCRIPTION/TRANSCRIPTION ACTIVATOR / zinc-binding motifs / protein-protein complex / TAZ zinc finger / TRANSCRIPTION-TRANSCRIPTION ACTIVATOR COMPLEX |
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機能・相同性 | 機能・相同性情報
embryonic process involved in female pregnancy / cranial nerve morphogenesis / TFAP2 (AP-2) family regulates transcription of other transcription factors / left/right pattern formation / pulmonary artery morphogenesis / embryonic heart tube left/right pattern formation / regulation of animal organ formation / adrenal cortex formation / Activation of the TFAP2 (AP-2) family of transcription factors / Regulation of FOXO transcriptional activity by acetylation ...embryonic process involved in female pregnancy / cranial nerve morphogenesis / TFAP2 (AP-2) family regulates transcription of other transcription factors / left/right pattern formation / pulmonary artery morphogenesis / embryonic heart tube left/right pattern formation / regulation of animal organ formation / adrenal cortex formation / Activation of the TFAP2 (AP-2) family of transcription factors / Regulation of FOXO transcriptional activity by acetylation / TRAF6 mediated IRF7 activation / nodal signaling pathway / Nuclear events mediated by NFE2L2 / Attenuation phase / embryonic camera-type eye morphogenesis / Regulation of gene expression by Hypoxia-inducible Factor / LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production / RUNX1 regulates transcription of genes involved in differentiation of myeloid cells / cAMP response element binding protein binding / sex determination / Formation of the beta-catenin:TCF transactivating complex / NOTCH1 Intracellular Domain Regulates Transcription / RUNX3 regulates NOTCH signaling / Notch-HLH transcription pathway / positive regulation of male gonad development / endocardial cushion development / determination of left/right asymmetry in lateral mesoderm / positive regulation of peroxisome proliferator activated receptor signaling pathway / granulocyte differentiation / lens morphogenesis in camera-type eye / left/right axis specification / positive regulation of cell adhesion molecule production / germ-line stem cell population maintenance / positive regulation of cell-cell adhesion / negative regulation of cardiac muscle cell proliferation / negative regulation of viral process / Regulation of lipid metabolism by PPARalpha / response to fluid shear stress / Cytoprotection by HMOX1 / trophectodermal cell differentiation / CD209 (DC-SIGN) signaling / Estrogen-dependent gene expression / peptide lactyltransferase (CoA-dependent) activity / outer kinetochore / peripheral nervous system development / negative regulation of interferon-beta production / cardiac neural crest cell development involved in heart development / Activation of the TFAP2 (AP-2) family of transcription factors / histone H3K18 acetyltransferase activity / N-terminal peptidyl-lysine acetylation / histone H3K27 acetyltransferase activity / MRF binding / bone morphogenesis / peroxisome proliferator activated receptor binding / determination of left/right symmetry / face morphogenesis / Regulation of gene expression by Hypoxia-inducible Factor / negative regulation of transcription by RNA polymerase I / FOXO-mediated transcription of cell death genes / peptide-lysine-N-acetyltransferase activity / histone acetyltransferase binding / cellular response to hepatocyte growth factor stimulus / ventricular septum morphogenesis / positive regulation of dendritic spine development / LBD domain binding / positive regulation of transforming growth factor beta receptor signaling pathway / heart looping / outflow tract morphogenesis / SMAD binding / skeletal muscle cell differentiation / uterus development / behavioral response to cocaine / acetyltransferase activity / TFIIB-class transcription factor binding / decidualization / positive regulation of double-strand break repair via homologous recombination / histone acetyltransferase complex / embryonic placenta development / positive regulation of G1/S transition of mitotic cell cycle / vasculogenesis / erythrocyte development / hematopoietic progenitor cell differentiation / long-term memory / positive regulation of cell cycle / response to mechanical stimulus / histone acetyltransferase activity / histone acetyltransferase / spleen development / 転移酵素; アシル基を移すもの; アミノアシル基以外のアシル基を移すもの / negative regulation of cell migration / transforming growth factor beta receptor signaling pathway / thymus development / liver development / neural tube closure / molecular function activator activity / central nervous system development / RNA polymerase II transcription regulatory region sequence-specific DNA binding / protein destabilization / protein modification process / chromatin DNA binding類似検索 - 分子機能 Helix Hairpins - #2200 / CITED / CITED / CREB-binding Protein; Chain A / TAZ domain / Nuclear receptor coactivator, CREB-bp-like, interlocking / Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily / Creb binding / Zinc finger, TAZ-type / TAZ domain superfamily ...Helix Hairpins - #2200 / CITED / CITED / CREB-binding Protein; Chain A / TAZ domain / Nuclear receptor coactivator, CREB-bp-like, interlocking / Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily / Creb binding / Zinc finger, TAZ-type / TAZ domain superfamily / TAZ zinc finger / Zinc finger TAZ-type profile. / TAZ zinc finger, present in p300 and CBP / Coactivator CBP, KIX domain / CREB-binding protein/p300, atypical RING domain / CBP/p300-type histone acetyltransferase domain / CBP/p300, atypical RING domain superfamily / KIX domain / CREB-binding protein/p300, atypical RING domain / KIX domain profile. / CBP/p300-type histone acetyltransferase (HAT) domain profile. / Histone acetyltransferase Rtt109/CBP / Histone acetylation protein / Histone acetylation protein / Coactivator CBP, KIX domain superfamily / Zinc finger ZZ-type signature. / Zinc-binding domain, present in Dystrophin, CREB-binding protein. / Zinc finger, ZZ type / Zinc finger, ZZ-type / Zinc finger, ZZ-type superfamily / Zinc finger ZZ-type profile. / Helix Hairpins / Nuclear receptor coactivator, interlocking / Helix non-globular / Special / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Zinc finger, RING/FYVE/PHD-type / Up-down Bundle / Mainly Alpha類似検索 - ドメイン・相同性 : / Histone lysine acetyltransferase CREBBP / Cbp/p300-interacting transactivator 2類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) Mus musculus (ハツカネズミ) |
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手法 | 溶液NMR / AMBER simulated annealing, minimization |
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データ登録者 | De Guzman, R.N. / Martinez-Yamout, M. / Dyson, H.J. / Wright, P.E. |
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引用 | ジャーナル: J.Biol.Chem. / 年: 2004 タイトル: Interaction of the TAZ1 domain of the CREB-binding protein with the activation domain of CITED2: regulation by competition between intrinsically unstructured ligands for non-identical binding sites. 著者: De Guzman, R.N. / Martinez-Yamout, M.A. / Dyson, H.J. / Wright, P.E. |
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履歴 | 登録 | 2003年10月28日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2004年3月23日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年4月29日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 1.3 | 2022年3月2日 | Group: Data collection / Database references / Derived calculations カテゴリ: database_2 / pdbx_nmr_software ...database_2 / pdbx_nmr_software / pdbx_nmr_spectrometer / pdbx_struct_assembly / pdbx_struct_conn_angle / pdbx_struct_oper_list / struct_conn / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name / _pdbx_nmr_spectrometer.model / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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改定 1.4 | 2024年5月22日 | Group: Data collection / カテゴリ: chem_comp_atom / chem_comp_bond |
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