Phase 0 - rapid depolarisation / response to pyrethroid / sodium ion binding / voltage-gated monoatomic ion channel activity / voltage-gated sodium channel complex / membrane depolarization during action potential / regulation of monoatomic ion transmembrane transport / cellular response to antibiotic / voltage-gated sodium channel activity / sodium ion transmembrane transport ...Phase 0 - rapid depolarisation / response to pyrethroid / sodium ion binding / voltage-gated monoatomic ion channel activity / voltage-gated sodium channel complex / membrane depolarization during action potential / regulation of monoatomic ion transmembrane transport / cellular response to antibiotic / voltage-gated sodium channel activity / sodium ion transmembrane transport / neuronal action potential / monoatomic cation channel activity / sensory perception of pain / response to wounding / nervous system development / calmodulin binding / axon / neuronal cell body / membrane / plasma membrane / cytoplasm Similarity search - Function
Voltage-gated Na+ ion channel, cytoplasmic domain / Cytoplasmic domain of voltage-gated Na+ ion channel / Sodium ion transport-associated / Sodium ion transport-associated / Voltage gated sodium channel, alpha subunit / Voltage-gated cation channel calcium and sodium / Voltage-dependent channel domain superfamily / Ion transport domain / Ion transport protein Similarity search - Domain/homology
PROTEIN (SODIUMCHANNELPROTEIN, BRAINIIALPHASUBUNIT)
Mass: 2480.853 Da / Num. of mol.: 1 / Fragment: S2 OF REPEAT I / Source method: obtained synthetically Details: SEQUENCE FROM MEMBRANES OF BRAIN CELLS OF RAT (RATTUS NORVEGICUS) References: UniProt: P08104
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Experimental details
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Experiment
Experiment
Method: SOLUTION NMR
NMR experiment
Conditions-ID
Experiment-ID
Solution-ID
Type
1
1
1
DQF-COSY
1
2
1
HOHAHA
1
3
1
NOESY
NMR details
Text: SEE JOURNAL REFERENCE
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Sample preparation
Details
Contents: MICELLE MOLAR RATIO DPC/ IS2 = 68
Sample conditions
pH: 3.3 / Temperature: 303 K
Crystal grow
*PLUS
Method: other / Details: NMR
-
NMR measurement
NMR spectrometer
Type
Manufacturer
Model
Field strength (MHz)
Spectrometer-ID
Bruker AM500
Bruker
AM500
500
1
Bruker AM600
Bruker
AM600
600
2
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Processing
NMR software
Name
Version
Developer
Classification
X-PLOR
3.851
BRUNGER
refinement
XPLOR
3.851
structuresolution
Refinement
Method: simulated annealing / Software ordinal: 1 Details: STRUCTURES HAVE BEEN RECALCULATED USING PARAMETERS PARALLHDG5.1.PRO (MICHAEL NILGES)
NMR ensemble
Conformer selection criteria: ENERGY / Conformers calculated total number: 50 / Conformers submitted total number: 30
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