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Open data
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Basic information
Entry | Database: PDB / ID: 1q3x | ||||||
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Title | Crystal structure of the catalytic region of human MASP-2 | ||||||
![]() | Mannan-binding lectin serine protease 2 | ||||||
![]() | HYDROLASE / complement / serine protease / modular structure / hinge bending / autoactivation | ||||||
Function / homology | ![]() mannan-binding lectin-associated serine protease-2 / complement component C4b binding / Ficolins bind to repetitive carbohydrate structures on the target cell surface / Lectin pathway of complement activation / complement activation, lectin pathway / Initial triggering of complement / complement activation, classical pathway / calcium-dependent protein binding / peptidase activity / serine-type endopeptidase activity ...mannan-binding lectin-associated serine protease-2 / complement component C4b binding / Ficolins bind to repetitive carbohydrate structures on the target cell surface / Lectin pathway of complement activation / complement activation, lectin pathway / Initial triggering of complement / complement activation, classical pathway / calcium-dependent protein binding / peptidase activity / serine-type endopeptidase activity / calcium ion binding / SARS-CoV-2 activates/modulates innate and adaptive immune responses / proteolysis / extracellular space / extracellular exosome / extracellular region / identical protein binding Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Harmat, V. / Gal, P. / Kardos, J. / Szilagyi, K. / Ambrus, G. / Naray-Szabo, G. / Zavodszky, P. | ||||||
![]() | ![]() Title: The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions Authors: Harmat, V. / Gal, P. / Kardos, J. / Szilagyi, K. / Ambrus, G. / Vegh, B. / Naray-Szabo, G. / Zavodsky, P. #1: ![]() Title: Natural substrates and inhibitors of mannan-binding lectin-associated serine protease 1 and 2: A study on recombinant catalytic fragments Authors: Ambrus, G. / Gal, P. / Kojima, M. / Szilagyi, K. / Balczer, J. / Antal, J. / Graf, L. / Laich, A. / Moffat, B.E. / Schwaelbe, W. / Sim, R.B. / Zvodszky, P. #2: ![]() Title: Crystal structure of the catalytic domain of human complement C1s: a serine protease with a handle Authors: Gaboriaud, C. / Rossi, V. / Bally, I. / Arlaud, G.J. / Fontecilla-Camps, J.C. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 146.3 KB | Display | ![]() |
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PDB format | ![]() | 112.4 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 452 KB | Display | ![]() |
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Full document | ![]() | 460.8 KB | Display | |
Data in XML | ![]() | 28.6 KB | Display | |
Data in CIF | ![]() | 40.8 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 1elvS S: Starting model for refinement |
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Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1 / Refine code: 1
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