登録情報 | データベース: PDB / ID: 1n46 |
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タイトル | CRYSTAL STRUCTURE OF HUMAN TR BETA LIGAND-BINDING DOMAIN COMPLEXED WITH A POTENT SUBTYPE-SELECTIVE THYROMIMETIC |
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要素 | Thyroid hormone receptor Beta-1 |
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キーワード | TRANSCRIPTION |
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機能・相同性 | 機能・相同性情報
retinal cone cell apoptotic process / negative regulation of female receptivity / female courtship behavior / retinal cone cell development / thyroid hormone receptor signaling pathway / positive regulation of thyroid hormone receptor signaling pathway / cellular response to thyroid hormone stimulus / regulation of heart contraction / type I pneumocyte differentiation / thyroid hormone binding ...retinal cone cell apoptotic process / negative regulation of female receptivity / female courtship behavior / retinal cone cell development / thyroid hormone receptor signaling pathway / positive regulation of thyroid hormone receptor signaling pathway / cellular response to thyroid hormone stimulus / regulation of heart contraction / type I pneumocyte differentiation / thyroid hormone binding / retinoic acid receptor signaling pathway / sensory perception of sound / SUMOylation of intracellular receptors / mRNA transcription by RNA polymerase II / chromatin DNA binding / transcription coactivator binding / Nuclear Receptor transcription pathway / RNA polymerase II transcription regulator complex / nuclear receptor activity / sequence-specific double-stranded DNA binding / cell differentiation / nuclear body / DNA-binding transcription factor activity, RNA polymerase II-specific / DNA-binding transcription factor activity / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-templated transcription / chromatin / negative regulation of transcription by RNA polymerase II / enzyme binding / positive regulation of transcription by RNA polymerase II / DNA binding / zinc ion binding / nucleoplasm / nucleus類似検索 - 分子機能 Thyroid hormone receptor / : / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors ...Thyroid hormone receptor / : / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Ligand-binding domain of nuclear hormone receptor / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / 分子置換 / 解像度: 2.2 Å |
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データ登録者 | Dow, R.L. / Schneider, S.R. / Paight, E.S. / Hank, R.F. / Chiang, P. / Cornelius, P. / Lee, E. / Newsome, W.P. / Swick, A.G. / Spitzer, J. ...Dow, R.L. / Schneider, S.R. / Paight, E.S. / Hank, R.F. / Chiang, P. / Cornelius, P. / Lee, E. / Newsome, W.P. / Swick, A.G. / Spitzer, J. / Hargrove, D.M. / Patterson, T.A. / Pandit, J. / Chrunyk, B.A. / LeMotte, P.K. / Danley, D.E. / Rosner, M.H. / Ammirati, M.J. / Simons, S.P. / Schulte, G.K. / Tate, B.F. / DaSilva-Jardine, P. |
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引用 | ジャーナル: Bioorg.Med.Chem.Lett. / 年: 2003 タイトル: Discovery of a Novel Series of 6-Azauracil-Based Thyroid Hormone Receptor Ligands: Potent, TRbeta Subtype-Selective Thyromimetics 著者: Dow, R.L. / Schneider, S.R. / Paight, E.S. / Hank, R.F. / Chiang, P. / Cornelius, P. / Lee, E. / Newsome, W.P. / Swick, A.G. / Spitzer, J. / Hargrove, D.M. / Patterson, T.A. / Pandit, J. / ...著者: Dow, R.L. / Schneider, S.R. / Paight, E.S. / Hank, R.F. / Chiang, P. / Cornelius, P. / Lee, E. / Newsome, W.P. / Swick, A.G. / Spitzer, J. / Hargrove, D.M. / Patterson, T.A. / Pandit, J. / Chrunyk, B.A. / LeMotte, P.K. / Danley, D.E. / Rosner, M.H. / Ammirati, M.J. / Simons, S.P. / Schulte, G.K. / Tate, B.F. / DaSilva-Jardine, P. |
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履歴 | 登録 | 2002年10月30日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2003年4月22日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年4月28日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 1.3 | 2018年1月31日 | Group: Experimental preparation / カテゴリ: exptl_crystal_grow / Item: _exptl_crystal_grow.temp |
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改定 1.4 | 2018年4月4日 | Group: Data collection / カテゴリ: diffrn_source / Item: _diffrn_source.type |
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改定 1.5 | 2024年2月14日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / struct_ncs_dom_lim / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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