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- PDB-1mgs: THE SOLUTION STRUCTURE OF MELANOMA GROWTH STIMULATING ACTIVITY -

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Basic information

Entry
Database: PDB / ID: 1mgs
TitleTHE SOLUTION STRUCTURE OF MELANOMA GROWTH STIMULATING ACTIVITY
ComponentsHUMAN MELANOMA GROWTH STIMULATORY ACTIVITY
KeywordsCHEMOKINE(GROWTH FACTOR)
Function / homology
Function and homology information


CXCR chemokine receptor binding / chemokine-mediated signaling pathway / Chemokine receptors bind chemokines / chemokine activity / Interleukin-10 signaling / enzyme activator activity / neutrophil chemotaxis / growth factor activity / specific granule lumen / chemotaxis ...CXCR chemokine receptor binding / chemokine-mediated signaling pathway / Chemokine receptors bind chemokines / chemokine activity / Interleukin-10 signaling / enzyme activator activity / neutrophil chemotaxis / growth factor activity / specific granule lumen / chemotaxis / antimicrobial humoral immune response mediated by antimicrobial peptide / tertiary granule lumen / nervous system development / G alpha (i) signalling events / actin cytoskeleton organization / cellular response to lipopolysaccharide / intracellular signal transduction / inflammatory response / G protein-coupled receptor signaling pathway / negative regulation of cell population proliferation / signaling receptor binding / Neutrophil degranulation / signal transduction / extracellular space / extracellular region
Similarity search - Function
CXC chemokine / CXC chemokine, conserved site / Small cytokines (intercrine/chemokine) C-x-C subfamily signature. / CXC Chemokine domain / Chemokine beta/gamma/delta / Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). / Chemokine interleukin-8-like domain / Chemokine interleukin-8-like superfamily / Small cytokines (intecrine/chemokine), interleukin-8 like / OB fold (Dihydrolipoamide Acetyltransferase, E2P) - #40 ...CXC chemokine / CXC chemokine, conserved site / Small cytokines (intercrine/chemokine) C-x-C subfamily signature. / CXC Chemokine domain / Chemokine beta/gamma/delta / Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). / Chemokine interleukin-8-like domain / Chemokine interleukin-8-like superfamily / Small cytokines (intecrine/chemokine), interleukin-8 like / OB fold (Dihydrolipoamide Acetyltransferase, E2P) - #40 / OB fold (Dihydrolipoamide Acetyltransferase, E2P) / Beta Barrel / Mainly Beta
Similarity search - Domain/homology
Growth-regulated alpha protein
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodSOLUTION NMR
AuthorsFairbrother, W.J.
Citation
Journal: J.Mol.Biol. / Year: 1994
Title: The solution structure of melanoma growth stimulating activity.
Authors: Fairbrother, W.J. / Reilly, D. / Colby, T.J. / Hesselgesser, J. / Horuk, R.
#1: Journal: FEBS Lett. / Year: 1993
Title: 1H Assignment and Secondary Structure Determination of Human Melanoma Growth Stimulating Activity (Mgsa) by NMR Spectroscopy
Authors: Fairbrother, W.J. / Reilly, D. / Colby, T.J. / Horuk, R.
History
DepositionJul 19, 1994Processing site: BNL
Revision 1.0Sep 30, 1994Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Feb 23, 2022Group: Database references / Derived calculations / Other
Category: database_2 / pdbx_database_status ...database_2 / pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.process_site

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Assembly

Deposited unit
A: HUMAN MELANOMA GROWTH STIMULATORY ACTIVITY
B: HUMAN MELANOMA GROWTH STIMULATORY ACTIVITY


Theoretical massNumber of molelcules
Total (without water)15,7542
Polymers15,7542
Non-polymers00
Water0
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Atom site foot note1: THE CYS 11 - CYS 51 DISULFIDE BRIDGE IS LEFT-HANDED. / 2: RESIDUES 1 - 7 AND 70 - 73 ARE ILL-DEFINED.
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)25 / -
Representative

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Components

#1: Protein HUMAN MELANOMA GROWTH STIMULATORY ACTIVITY


Mass: 7877.215 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: POTENTIAL / References: UniProt: P09341

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Processing

Software
NameVersionClassification
X-PLOR3.1model building
X-PLOR3.1refinement
X-PLOR3.1phasing
NMR ensembleConformers submitted total number: 25

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