登録情報 | データベース: PDB / ID: 1m61 |
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タイトル | Crystal structure of the apo SH2 domains of ZAP-70 |
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要素 | TYROSINE-PROTEIN KINASE ZAP-70 |
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キーワード | TRANSFERASE / apo form |
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機能・相同性 | 機能・相同性情報
T cell aggregation / T cell migration / positive regulation of alpha-beta T cell proliferation / negative thymic T cell selection / beta selection / positive thymic T cell selection / positive regulation of alpha-beta T cell differentiation / positive regulation of T cell differentiation / T cell receptor complex / B cell activation ...T cell aggregation / T cell migration / positive regulation of alpha-beta T cell proliferation / negative thymic T cell selection / beta selection / positive thymic T cell selection / positive regulation of alpha-beta T cell differentiation / positive regulation of T cell differentiation / T cell receptor complex / B cell activation / Translocation of ZAP-70 to Immunological synapse / extrinsic component of cytoplasmic side of plasma membrane / RHOH GTPase cycle / Generation of second messenger molecules / immunological synapse / T cell differentiation / Nuclear events stimulated by ALK signaling in cancer / cell surface receptor protein tyrosine kinase signaling pathway / T cell activation / positive regulation of calcium-mediated signaling / phosphotyrosine residue binding / non-specific protein-tyrosine kinase / calcium-mediated signaling / non-membrane spanning protein tyrosine kinase activity / peptidyl-tyrosine phosphorylation / cell-cell junction / T cell receptor signaling pathway / protein tyrosine kinase activity / adaptive immune response / cell differentiation / intracellular signal transduction / immune response / protein phosphorylation / innate immune response / signaling receptor binding / ATP binding / plasma membrane / cytosol / cytoplasm類似検索 - 分子機能 Syk Kinase; Chain A, domain 2 / Syk Kinase; Chain A, domain 2 / Tyrosine-protein kinase, non-receptor SYK/ZAP-70 / Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily / SYK/ZAP-70, N-terminal SH2 domain / SH2 domain / SHC Adaptor Protein / : / SH2 domain / Src homology 2 (SH2) domain profile. ...Syk Kinase; Chain A, domain 2 / Syk Kinase; Chain A, domain 2 / Tyrosine-protein kinase, non-receptor SYK/ZAP-70 / Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily / SYK/ZAP-70, N-terminal SH2 domain / SH2 domain / SHC Adaptor Protein / : / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / SH2 domain superfamily / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 PHOSPHATE ION / Tyrosine-protein kinase ZAP-70類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.5 Å |
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データ登録者 | Folmer, R.H.A. / Geschwindner, S. / Xue, Y. |
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引用 | ジャーナル: Biochemistry / 年: 2002 タイトル: Crystal structure and NMR studies of the apo SH2 domains of ZAP-70: two bikes rather than a tandem 著者: Folmer, R.H.A. / Geschwindner, S. / Xue, Y. |
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履歴 | 登録 | 2002年7月11日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2003年7月15日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年4月28日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 1.3 | 2018年3月7日 | Group: Data collection / カテゴリ: diffrn_source / Item: _diffrn_source.pdbx_synchrotron_site |
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改定 1.4 | 2024年2月14日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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