登録情報 | データベース: PDB / ID: 1l8c |
---|
タイトル | STRUCTURAL BASIS FOR HIF-1ALPHA/CBP RECOGNITION IN THE CELLULAR HYPOXIC RESPONSE |
---|
要素 | - CREB-binding protein
- Hypoxia-inducible factor 1 alpha
|
---|
キーワード | GENE REGULATION |
---|
機能・相同性 | 機能・相同性情報
epithelial cell differentiation involved in mammary gland alveolus development / neural fold elevation formation / Activation of the TFAP2 (AP-2) family of transcription factors / iris morphogenesis / Regulation of FOXO transcriptional activity by acetylation / TRAF6 mediated IRF7 activation / intestinal epithelial cell maturation / Nuclear events mediated by NFE2L2 / positive regulation of nitric oxide metabolic process / Attenuation phase ...epithelial cell differentiation involved in mammary gland alveolus development / neural fold elevation formation / Activation of the TFAP2 (AP-2) family of transcription factors / iris morphogenesis / Regulation of FOXO transcriptional activity by acetylation / TRAF6 mediated IRF7 activation / intestinal epithelial cell maturation / Nuclear events mediated by NFE2L2 / positive regulation of nitric oxide metabolic process / Attenuation phase / hypoxia-inducible factor-1alpha signaling pathway / LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production / Regulation of gene expression by Hypoxia-inducible Factor / RUNX1 regulates transcription of genes involved in differentiation of myeloid cells / positive regulation of chemokine-mediated signaling pathway / Formation of the beta-catenin:TCF transactivating complex / NOTCH1 Intracellular Domain Regulates Transcription / RUNX3 regulates NOTCH signaling / cAMP response element binding protein binding / elastin metabolic process / regulation of transforming growth factor beta2 production / Notch-HLH transcription pathway / glandular epithelial cell maturation / Transcriptional and post-translational regulation of MITF-M expression and activity / hemoglobin biosynthetic process / negative regulation of mesenchymal cell apoptotic process / cardiac ventricle morphogenesis / connective tissue replacement involved in inflammatory response wound healing / negative regulation of growth / positive regulation of hormone biosynthetic process / germ-line stem cell population maintenance / negative regulation of viral process / Cellular response to hypoxia / Regulation of lipid metabolism by PPARalpha / retina vasculature development in camera-type eye / mesenchymal cell apoptotic process / regulation of protein neddylation / Cytoprotection by HMOX1 / negative regulation of bone mineralization / PTK6 Expression / intracellular oxygen homeostasis / collagen metabolic process / B-1 B cell homeostasis / Estrogen-dependent gene expression / CD209 (DC-SIGN) signaling / vascular endothelial growth factor production / peptide lactyltransferase (CoA-dependent) activity / outer kinetochore / dopaminergic neuron differentiation / negative regulation of interferon-beta production / transcription regulator activator activity / N-terminal peptidyl-lysine acetylation / histone H3K18 acetyltransferase activity / histone H3K27 acetyltransferase activity / STAT3 nuclear events downstream of ALK signaling / negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway / negative regulation of thymocyte apoptotic process / lactate metabolic process / MRF binding / positive regulation of cytokine production involved in inflammatory response / insulin secretion involved in cellular response to glucose stimulus / negative regulation of TOR signaling / positive regulation of vascular endothelial growth factor receptor signaling pathway / response to iron ion / neural crest cell migration / Regulation of gene expression by Hypoxia-inducible Factor / face morphogenesis / embryonic hemopoiesis / regulation of glycolytic process / negative regulation of transcription by RNA polymerase I / motile cilium / DNA-binding transcription repressor activity / protein-lysine-acetyltransferase activity / cellular response to hepatocyte growth factor stimulus / PTK6 promotes HIF1A stabilization / muscle cell cellular homeostasis / positive regulation of neuroblast proliferation / digestive tract morphogenesis / DNA-binding transcription activator activity / axonal transport of mitochondrion / bone mineralization / response to muscle activity / acetyltransferase activity / heart looping / E-box binding / intracellular glucose homeostasis / TOR signaling / outflow tract morphogenesis / TFIIB-class transcription factor binding / positive regulation of vascular endothelial growth factor production / positive regulation of macroautophagy / histone acetyltransferase complex / positive regulation of epithelial cell migration / cellular response to interleukin-1 / epithelial to mesenchymal transition / neuroblast proliferation / positive regulation of blood vessel endothelial cell migration / chondrocyte differentiation / embryonic placenta development / positive regulation of insulin secretion involved in cellular response to glucose stimulus類似検索 - 分子機能 CREB-binding Protein; Chain A / TAZ domain / Hypoxia-inducible factor-1 alpha / HIF-1 alpha, transactivation domain, C-terminal / HIF-1 alpha C terminal transactivation domain / Hypoxia-inducible factor 1-alpha bHLH domain / Hypoxia-inducible factor, alpha subunit-like / Hypoxia-inducible factor-1 / PAS fold-3 / PAS fold ...CREB-binding Protein; Chain A / TAZ domain / Hypoxia-inducible factor-1 alpha / HIF-1 alpha, transactivation domain, C-terminal / HIF-1 alpha C terminal transactivation domain / Hypoxia-inducible factor 1-alpha bHLH domain / Hypoxia-inducible factor, alpha subunit-like / Hypoxia-inducible factor-1 / PAS fold-3 / PAS fold / Nuclear receptor coactivator, CREB-bp-like, interlocking / Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily / Creb binding / Zinc finger, TAZ-type / TAZ domain superfamily / TAZ zinc finger / Zinc finger TAZ-type profile. / TAZ zinc finger, present in p300 and CBP / : / Histone acetyltransferase p300-like, PHD domain / Coactivator CBP, KIX domain / CREB-binding protein/p300, atypical RING domain / CBP/p300-type histone acetyltransferase domain / CBP/p300, atypical RING domain superfamily / KIX domain / CREB-binding protein/p300, atypical RING domain / KIX domain profile. / CBP/p300-type histone acetyltransferase (HAT) domain profile. / Histone acetyltransferase Rtt109/CBP / Histone acetylation protein / Histone acetylation protein / Coactivator CBP, KIX domain superfamily / Zinc finger ZZ-type signature. / Zinc-binding domain, present in Dystrophin, CREB-binding protein. / Zinc finger, ZZ type / Zinc finger, ZZ-type / Zinc finger, ZZ-type superfamily / Zinc finger ZZ-type profile. / PAC motif / Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) / Nuclear receptor coactivator, interlocking / helix loop helix domain / Myc-type, basic helix-loop-helix (bHLH) domain / Myc-type, basic helix-loop-helix (bHLH) domain profile. / Helix-loop-helix DNA-binding domain superfamily / PAS fold / PAS fold / PAS domain / PAS repeat profile. / PAS domain / PAS domain superfamily / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / bromo domain / Bromodomain / Bromodomain (BrD) profile. / Bromodomain-like superfamily / Zinc finger, RING/FYVE/PHD-type / Up-down Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Histone lysine acetyltransferase CREBBP / Hypoxia-inducible factor 1-alpha類似検索 - 構成要素 |
---|
生物種 |  Mus musculus (ハツカネズミ)
Homo sapiens (ヒト) |
---|
手法 | 溶液NMR |
---|
データ登録者 | Dames, S.A. / Martinez-Yamout, M. / De Guzman, R.N. / Dyson, H.J. / Wright, P.E. |
---|
引用 | ジャーナル: Proc.Natl.Acad.Sci.USA / 年: 2002 タイトル: Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response. 著者: Dames, S.A. / Martinez-Yamout, M. / De Guzman, R.N. / Dyson, H.J. / Wright, P.E. |
---|
履歴 | 登録 | 2002年3月19日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2002年4月10日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2008年4月28日 | Group: Version format compliance |
---|
改定 1.2 | 2011年7月13日 | Group: Version format compliance |
---|
改定 1.3 | 2022年2月23日 | Group: Data collection / Database references / Derived calculations カテゴリ: database_2 / pdbx_nmr_software ...database_2 / pdbx_nmr_software / pdbx_struct_assembly / pdbx_struct_conn_angle / pdbx_struct_oper_list / struct_conn / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
---|
改定 1.4 | 2024年5月22日 | Group: Data collection / カテゴリ: chem_comp_atom / chem_comp_bond |
---|
|
---|
Remark 999 | SEQEUNCE AUTHOR STATES RESIDUE GLY56 IS A SEQUENCE VARIANT |
---|