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- PDB-1l8c: STRUCTURAL BASIS FOR HIF-1ALPHA/CBP RECOGNITION IN THE CELLULAR H... -
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Open data
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Basic information
Entry | Database: PDB / ID: 1l8c | ||||||
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Title | STRUCTURAL BASIS FOR HIF-1ALPHA/CBP RECOGNITION IN THE CELLULAR HYPOXIC RESPONSE | ||||||
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![]() | GENE REGULATION | ||||||
Function / homology | ![]() epithelial cell differentiation involved in mammary gland alveolus development / neural fold elevation formation / iris morphogenesis / Activation of the TFAP2 (AP-2) family of transcription factors / Regulation of FOXO transcriptional activity by acetylation / TRAF6 mediated IRF7 activation / Nuclear events mediated by NFE2L2 / positive regulation of chemokine-mediated signaling pathway / hypoxia-inducible factor-1alpha signaling pathway / Attenuation phase ...epithelial cell differentiation involved in mammary gland alveolus development / neural fold elevation formation / iris morphogenesis / Activation of the TFAP2 (AP-2) family of transcription factors / Regulation of FOXO transcriptional activity by acetylation / TRAF6 mediated IRF7 activation / Nuclear events mediated by NFE2L2 / positive regulation of chemokine-mediated signaling pathway / hypoxia-inducible factor-1alpha signaling pathway / Attenuation phase / elastin metabolic process / Regulation of gene expression by Hypoxia-inducible Factor / LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production / glandular epithelial cell maturation / RUNX1 regulates transcription of genes involved in differentiation of myeloid cells / cAMP response element binding protein binding / Formation of the beta-catenin:TCF transactivating complex / NOTCH1 Intracellular Domain Regulates Transcription / RUNX3 regulates NOTCH signaling / regulation of transforming growth factor beta2 production / Notch-HLH transcription pathway / connective tissue replacement involved in inflammatory response wound healing / cardiac ventricle morphogenesis / negative regulation of mesenchymal cell apoptotic process / hemoglobin biosynthetic process / positive regulation of hormone biosynthetic process / positive regulation of cell adhesion molecule production / germ-line stem cell population maintenance / mesenchymal cell apoptotic process / positive regulation of mitophagy / retina vasculature development in camera-type eye / Cellular response to hypoxia / intestinal epithelial cell maturation / negative regulation of growth / regulation of protein neddylation / collagen metabolic process / negative regulation of viral process / Regulation of lipid metabolism by PPARalpha / PTK6 Expression / intracellular oxygen homeostasis / negative regulation of bone mineralization / Cytoprotection by HMOX1 / B-1 B cell homeostasis / CD209 (DC-SIGN) signaling / vascular endothelial growth factor production / Estrogen-dependent gene expression / peptide lactyltransferase (CoA-dependent) activity / outer kinetochore / negative regulation of interferon-beta production / transcription regulator activator activity / dopaminergic neuron differentiation / negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway / lactate metabolic process / STAT3 nuclear events downstream of ALK signaling / histone H3K18 acetyltransferase activity / N-terminal peptidyl-lysine acetylation / histone H3K27 acetyltransferase activity / positive regulation of cytokine production involved in inflammatory response / MRF binding / negative regulation of thymocyte apoptotic process / positive regulation of vascular endothelial growth factor receptor signaling pathway / motile cilium / positive regulation of signaling receptor activity / insulin secretion involved in cellular response to glucose stimulus / peroxisome proliferator activated receptor binding / negative regulation of TOR signaling / response to iron ion / response to muscle activity / face morphogenesis / neural crest cell migration / Regulation of gene expression by Hypoxia-inducible Factor / regulation of glycolytic process / embryonic hemopoiesis / negative regulation of transcription by RNA polymerase I / peptide-lysine-N-acetyltransferase activity / DNA-binding transcription repressor activity / DNA-binding transcription activator activity / PTK6 promotes HIF1A stabilization / regulation of aerobic respiration / digestive tract morphogenesis / cellular response to hepatocyte growth factor stimulus / muscle cell cellular homeostasis / positive regulation of dendritic spine development / positive regulation of neuroblast proliferation / axonal transport of mitochondrion / positive regulation of epithelial cell migration / bone mineralization / heart looping / outflow tract morphogenesis / E-box binding / SMAD binding / intracellular glucose homeostasis / positive regulation of insulin secretion involved in cellular response to glucose stimulus / behavioral response to cocaine / acetyltransferase activity / TFIIB-class transcription factor binding / positive regulation of double-strand break repair via homologous recombination / histone acetyltransferase complex / positive regulation of vascular endothelial growth factor production / neuroblast proliferation Similarity search - Function | ||||||
Biological species | ![]() ![]() ![]() | ||||||
Method | SOLUTION NMR | ||||||
![]() | Dames, S.A. / Martinez-Yamout, M. / De Guzman, R.N. / Dyson, H.J. / Wright, P.E. | ||||||
![]() | ![]() Title: Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response. Authors: Dames, S.A. / Martinez-Yamout, M. / De Guzman, R.N. / Dyson, H.J. / Wright, P.E. | ||||||
History |
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Remark 999 | SEQEUNCE AUTHOR STATES RESIDUE GLY56 IS A SEQUENCE VARIANT |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 888 KB | Display | ![]() |
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PDB format | ![]() | 744.9 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 366.8 KB | Display | ![]() |
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Full document | ![]() | 584.6 KB | Display | |
Data in XML | ![]() | 39.7 KB | Display | |
Data in CIF | ![]() | 72 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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NMR ensembles |
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Components
#1: Protein | Mass: 10853.724 Da / Num. of mol.: 1 Fragment: TAZ1 (Transcription activation zinc finger) domain, Residues 345-439 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() ![]() |
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#2: Protein | Mass: 5565.170 Da / Num. of mol.: 1 Fragment: CTAD (C-Terminal activation) domain, Residues 776-826 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() |
#3: Chemical |
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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NMR experiment |
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Sample preparation
Details |
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Sample conditions | Ionic strength: 2.0 Millimolar / pH: 6.1 / Pressure: Ambient / Temperature: 298 K | ||||||||
Crystal grow | *PLUS Method: other / Details: NMR |
-NMR measurement
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M | |||||||||||||||
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Radiation wavelength | Relative weight: 1 | |||||||||||||||
NMR spectrometer |
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Processing
NMR software |
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Refinement | Software ordinal: 1 / Details: PEARLMAN, D.A. ET AL. (1995) COMP. PHYS.COMMU. | ||||||||||||||||||||
NMR ensemble | Conformer selection criteria: structures with the least restraint violations, structures with the lowest energy Conformers calculated total number: 200 / Conformers submitted total number: 20 |