登録情報 | データベース: PDB / ID: 1kez |
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タイトル | Crystal Structure of the Macrocycle-forming Thioesterase Domain of Erythromycin Polyketide Synthase (DEBS TE) |
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要素 | ERYTHRONOLIDE SYNTHASE |
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キーワード | TRANSFERASE / polyketide synthase / 6-deoxyerythronolide synthase / modular polyketide synthase / thioesterase / 6-dEB / TE / DEBS / alpha / beta-hydrolase / macrocycle |
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機能・相同性 | 機能・相同性情報
6-deoxyerythronolide-B synthase / erythronolide synthase activity / macrolide biosynthetic process / DIM/DIP cell wall layer assembly / fatty acid synthase activity / phosphopantetheine binding / 3-oxoacyl-[acyl-carrier-protein] synthase activity / fatty acid biosynthetic process / plasma membrane / cytoplasm類似検索 - 分子機能 Polyketide synthase, docking domain superfmaily / Polyketide synthase, thioesterase domain / Thioesterase / Polyketide synthase, docking domain / Erythronolide synthase docking domain / Thioesterase / Thioesterase domain / PKS_PP_betabranch / : / Polyketide synthase, ketoreductase domain ...Polyketide synthase, docking domain superfmaily / Polyketide synthase, thioesterase domain / Thioesterase / Polyketide synthase, docking domain / Erythronolide synthase docking domain / Thioesterase / Thioesterase domain / PKS_PP_betabranch / : / Polyketide synthase, ketoreductase domain / KR domain / Malonyl-CoA ACP transacylase, ACP-binding / Polyketide synthase, C-terminal extension / Ketoacyl-synthetase C-terminal extension / PKS_KR / Acyl transferase domain superfamily / Acyl transferase / Acyl transferase domain / Acyl transferase domain in polyketide synthase (PKS) enzymes. / Acyl transferase/acyl hydrolase/lysophospholipase / Ketosynthase family 3 (KS3) domain profile. / Polyketide synthase, phosphopantetheine-binding domain / Phosphopantetheine attachment site / Beta-ketoacyl synthase / Beta-ketoacyl synthase, active site / Ketosynthase family 3 (KS3) active site signature. / Polyketide synthase, beta-ketoacyl synthase domain / Beta-ketoacyl synthase, N-terminal / Beta-ketoacyl synthase, C-terminal / Beta-ketoacyl synthase, N-terminal domain / Beta-ketoacyl synthase, C-terminal domain / Thiolase-like / Phosphopantetheine attachment site / Phosphopantetheine attachment site. / Phosphopantetheine attachment site / ACP-like superfamily / Carrier protein (CP) domain profile. / Phosphopantetheine binding ACP domain / Alpha/Beta hydrolase fold, catalytic domain / Alpha/Beta hydrolase fold / NAD(P)-binding domain superfamily / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 6-deoxyerythronolide-B synthase EryA3, modules 5 and 6類似検索 - 構成要素 |
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生物種 | Saccharopolyspora erythraea (バクテリア) |
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手法 | X線回折 / シンクロトロン / 多重同系置換 / 解像度: 2.8 Å |
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データ登録者 | Tsai, S.-C. / Miercke, L.J.W. / Krucinski, J. / Gokhale, R. / Chen, J.C.-H. / Foster, P.G. / Cane, D.E. / Khosla, C. / Stroud, R.M. |
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引用 | ジャーナル: Proc.Natl.Acad.Sci.USA / 年: 2001 タイトル: Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel. 著者: Tsai, S.C. / Miercke, L.J. / Krucinski, J. / Gokhale, R. / Chen, J.C. / Foster, P.G. / Cane, D.E. / Khosla, C. / Stroud, R.M. |
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履歴 | 登録 | 2001年11月19日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2002年1月9日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年4月27日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 1.3 | 2019年7月24日 | Group: Data collection / Refinement description / カテゴリ: software / Item: _software.name |
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改定 1.4 | 2024年2月7日 | Group: Data collection / Database references カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details |
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