- PDB-1ity: Solution structure of the DNA binding domain of human TRF1 -
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基本情報
登録情報
データベース: PDB / ID: 1ity
タイトル
Solution structure of the DNA binding domain of human TRF1
要素
TRF1
キーワード
DNA BINDING PROTEIN / helix-turn-helix / telomeres / DNA binding / Myb domain / RIKEN Structural Genomics/Proteomics Initiative / RSGI / Structural Genomics
機能・相同性
機能・相同性情報
positive regulation of shelterin complex assembly / negative regulation of establishment of protein localization to telomere / negative regulation of establishment of RNA localization to telomere / negative regulation of establishment of protein-containing complex localization to telomere / negative regulation of telomere maintenance via semi-conservative replication / negative regulation of exonuclease activity / negative regulation of telomeric D-loop disassembly / meiotic telomere clustering / telomerase activity / t-circle formation ...positive regulation of shelterin complex assembly / negative regulation of establishment of protein localization to telomere / negative regulation of establishment of RNA localization to telomere / negative regulation of establishment of protein-containing complex localization to telomere / negative regulation of telomere maintenance via semi-conservative replication / negative regulation of exonuclease activity / negative regulation of telomeric D-loop disassembly / meiotic telomere clustering / telomerase activity / t-circle formation / telomeric D-loop disassembly / shelterin complex / Telomere C-strand synthesis initiation / double-stranded telomeric DNA binding / Telomere C-strand (Lagging Strand) Synthesis / : / positive regulation of telomere maintenance / nuclear telomere cap complex / ankyrin repeat binding / Processive synthesis on the C-strand of the telomere / Polymerase switching on the C-strand of the telomere / Removal of the Flap Intermediate from the C-strand / G-rich strand telomeric DNA binding / telomere capping / DNA binding, bending / negative regulation of telomere maintenance via telomere lengthening / telomeric DNA binding / negative regulation of DNA replication / negative regulation of telomere maintenance via telomerase / Telomere Extension By Telomerase / telomere maintenance via telomerase / Packaging Of Telomere Ends / Recognition and association of DNA glycosylase with site containing an affected purine / Cleavage of the damaged purine / Recognition and association of DNA glycosylase with site containing an affected pyrimidine / Cleavage of the damaged pyrimidine / Inhibition of DNA recombination at telomere / Meiotic synapsis / telomere maintenance / DNA Damage/Telomere Stress Induced Senescence / fibrillar center / spindle / microtubule binding / chromosome, telomeric region / nuclear body / cell division / nucleolus / protein homodimerization activity / DNA binding / nucleoplasm / identical protein binding / nucleus / cytoplasm 類似検索 - 分子機能
名称: EMBOSS / バージョン: 5 / 開発者: Nakai, T., Kidera, A., and Nakamura, H. / 分類: 精密化
精密化
手法: distance geometry, simulated annealing / ソフトェア番号: 1 詳細: The structures are generated by 4D simulated annealing with EMBOSS, based on a total of 916 experimental restraints, 852 are NOE-derived distance restraints, 36 hydrogen restraints and 28 ...詳細: The structures are generated by 4D simulated annealing with EMBOSS, based on a total of 916 experimental restraints, 852 are NOE-derived distance restraints, 36 hydrogen restraints and 28 dihedral restraints. 25 out of 100 structures which have the lowest violation and a low energies were selected for the final set.
代表構造
選択基準: closest to the average
NMRアンサンブル
コンフォーマー選択の基準: structures with the least restraint violations 計算したコンフォーマーの数: 100 / 登録したコンフォーマーの数: 25