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- PDB-1irp: SOLUTION STRUCTURE OF HUMAN INTERLEUKIN-1 RECEPTOR ANTAGONIST PROTEIN -

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Entry
Database: PDB / ID: 1irp
TitleSOLUTION STRUCTURE OF HUMAN INTERLEUKIN-1 RECEPTOR ANTAGONIST PROTEIN
ComponentsINTERLEUKIN-1 RECEPTOR ANTAGONIST
KeywordsCYTOKINE
Function / homology
Function and homology information


interleukin-1 type I receptor antagonist activity / interleukin-1 type II receptor antagonist activity / interleukin-1, type I receptor binding / interleukin-1 receptor antagonist activity / interleukin-1, type II receptor binding / negative regulation of interleukin-1-mediated signaling pathway / negative regulation of heterotypic cell-cell adhesion / interleukin-1 receptor binding / inflammatory response to antigenic stimulus / insulin secretion ...interleukin-1 type I receptor antagonist activity / interleukin-1 type II receptor antagonist activity / interleukin-1, type I receptor binding / interleukin-1 receptor antagonist activity / interleukin-1, type II receptor binding / negative regulation of interleukin-1-mediated signaling pathway / negative regulation of heterotypic cell-cell adhesion / interleukin-1 receptor binding / inflammatory response to antigenic stimulus / insulin secretion / Interleukin-10 signaling / response to glucocorticoid / cytokine activity / acute-phase response / lipid metabolic process / Interleukin-1 signaling / immune response / centrosome / extracellular space / extracellular exosome / nucleoplasm / plasma membrane / cytosol
Similarity search - Function
Interleukin-1 receptor antagonist/Interleukin-36 / Interleukin-1 conserved site / Interleukin-1 signature. / Interleukin-1 homologues / Interleukin-1 family / Interleukin-1 / 18 / Cytokine IL1/FGF / Trefoil (Acidic Fibroblast Growth Factor, subunit A) - #50 / Trefoil (Acidic Fibroblast Growth Factor, subunit A) / Trefoil / Mainly Beta
Similarity search - Domain/homology
Interleukin-1 receptor antagonist protein
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodSOLUTION NMR
AuthorsStockman, B.J. / Scahill, T.A. / Strakalaitis, N.A.
Citation
Journal: FEBS Lett. / Year: 1994
Title: Solution structure of human interleukin-1 receptor antagonist protein.
Authors: Stockman, B.J. / Scahill, T.A. / Strakalaitis, N.A. / Brunner, D.P. / Yem, A.W. / Deibel Jr., M.R.
#1: Journal: Bull.Magn.Reson. / Year: 1992
Title: Interleukin-1 Receptor Antagonist Protein: Solution Secondary Structure from Noe'S and 1H Alpha and 13C Alpha Chemical Shifts
Authors: Stockman, B.J. / Scahill, T.A. / Euvrard, A. / Strakalaitis, N.A. / Brunner, D.P. / Yem, A.W. / Deibel, M.R.
#2: Journal: J.Biomol.NMR / Year: 1992
Title: Proton, Carbon and Nitrogen Chemical Shifts Accurately Delineate Differences and Similarities in Secondary Structure between the Homologous Proteins Irap and Il-1Beta
Authors: Stockman, B.J. / Scahill, T.A. / Strakalaitis, N.A. / Brunner, D.P. / Yem, A.W. / Deibel, M.R.
#3: Journal: Biochemistry / Year: 1992
Title: Secondary Structure and Topology of Interleukin-1 Receptor Antagonist Protein Determined by Heteronuclear Three-Dimensional NMR Spectroscopy
Authors: Stockman, B.J. / Scahill, T.A. / Roy, M. / Ulrich, E.L. / Strakalaitis, N.A. / Brunner, D.P. / Yem, A.W. / Deibel, M.R.
History
DepositionOct 18, 1994Processing site: BNL
Revision 1.0Feb 27, 1995Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Feb 23, 2022Group: Database references / Derived calculations / Other
Category: database_2 / pdbx_database_status ...database_2 / pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.process_site
Revision 1.4May 22, 2024Group: Data collection / Category: chem_comp_atom / chem_comp_bond

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Structure viewerMolecule:
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Assembly

Deposited unit
A: INTERLEUKIN-1 RECEPTOR ANTAGONIST


Theoretical massNumber of molelcules
Total (without water)17,2771
Polymers17,2771
Non-polymers00
Water00
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)12 / -
Representative

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Components

#1: Protein INTERLEUKIN-1 RECEPTOR ANTAGONIST


Mass: 17276.602 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / References: UniProt: P18510

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Sample preparation

Crystal grow
*PLUS
Method: other / Details: NMR

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Processing

NMR softwareName: DGII / Developer: BIOSYM TECHNOLOGIES, INC. / Classification: refinement
NMR ensembleConformers submitted total number: 12

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