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Yorodumi- PDB-1hrf: SOLUTION STRUCTURE OF THE EPIDERMAL GROWTH FACTOR-LIKE DOMAIN OF ... -
+Open data
-Basic information
Entry | Database: PDB / ID: 1hrf | ||||||
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Title | SOLUTION STRUCTURE OF THE EPIDERMAL GROWTH FACTOR-LIKE DOMAIN OF HEREGULIN-ALPHA, A LIGAND FOR P180ERB4 | ||||||
Components | HEREGULIN ALPHA | ||||||
Keywords | GROWTH FACTOR | ||||||
Function / homology | Function and homology information ERBB3 signaling pathway / positive regulation of peptidyl-tyrosine autophosphorylation / sequestering of metal ion / ERBB4 signaling pathway / ERBB4-ERBB4 signaling pathway / ventricular cardiac muscle cell differentiation / positive regulation of striated muscle cell differentiation / negative regulation of secretion / endocardial cell differentiation / animal organ development ...ERBB3 signaling pathway / positive regulation of peptidyl-tyrosine autophosphorylation / sequestering of metal ion / ERBB4 signaling pathway / ERBB4-ERBB4 signaling pathway / ventricular cardiac muscle cell differentiation / positive regulation of striated muscle cell differentiation / negative regulation of secretion / endocardial cell differentiation / animal organ development / ERBB2-ERBB4 signaling pathway / GRB7 events in ERBB2 signaling / neural crest cell development / ERBB2 Activates PTK6 Signaling / cardiac muscle cell myoblast differentiation / cell communication / protein tyrosine kinase activator activity / transmembrane receptor protein tyrosine kinase activator activity / PI3K events in ERBB4 signaling / cardiac muscle cell differentiation / Signaling by ERBB4 / mammary gland development / chemorepellent activity / ventricular trabecula myocardium morphogenesis / ErbB-3 class receptor binding / ERBB2 Regulates Cell Motility / regulation of postsynaptic neurotransmitter receptor internalization / PI3K events in ERBB2 signaling / activation of transmembrane receptor protein tyrosine kinase activity / ERBB signaling pathway / negative regulation of cardiac muscle cell apoptotic process / ERBB2-ERBB3 signaling pathway / Long-term potentiation / Signaling by ERBB2 / positive regulation of cell adhesion / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / SHC1 events in ERBB4 signaling / GRB2 events in ERBB2 signaling / SHC1 events in ERBB2 signaling / Nuclear signaling by ERBB4 / positive regulation of cardiac muscle cell proliferation / transcription coregulator activity / cell surface receptor protein tyrosine kinase signaling pathway / activation of protein kinase B activity / Downregulation of ERBB2:ERBB3 signaling / Signaling by ERBB2 TMD/JMD mutants / cytokine activity / Signaling by ERBB2 KD Mutants / Downregulation of ERBB2 signaling / growth factor activity / wound healing / positive regulation of protein-containing complex assembly / receptor tyrosine kinase binding / Constitutive Signaling by Aberrant PI3K in Cancer / integrin binding / PIP3 activates AKT signaling / nervous system development / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / RAF/MAP kinase cascade / positive regulation of cell growth / cell population proliferation / positive regulation of ERK1 and ERK2 cascade / cell differentiation / receptor ligand activity / intracellular signal transduction / apical plasma membrane / signaling receptor binding / negative regulation of DNA-templated transcription / positive regulation of cell population proliferation / glutamatergic synapse / extracellular space / extracellular region / nucleoplasm / membrane / plasma membrane Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | SOLUTION NMR | ||||||
Authors | Nagata, K. / Kohda, D. / Hatanaka, H. / Ichikawa, S. / Inagaki, F. | ||||||
Citation | Journal: EMBO J. / Year: 1994 Title: Solution structure of the epidermal growth factor-like domain of heregulin-alpha, a ligand for p180erbB-4. Authors: Nagata, K. / Kohda, D. / Hatanaka, H. / Ichikawa, S. / Matsuda, S. / Yamamoto, T. / Suzuki, A. / Inagaki, F. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 1hrf.cif.gz | 233.2 KB | Display | PDBx/mmCIF format |
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PDB format | pdb1hrf.ent.gz | 202.4 KB | Display | PDB format |
PDBx/mmJSON format | 1hrf.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 1hrf_validation.pdf.gz | 344.1 KB | Display | wwPDB validaton report |
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Full document | 1hrf_full_validation.pdf.gz | 416 KB | Display | |
Data in XML | 1hrf_validation.xml.gz | 17 KB | Display | |
Data in CIF | 1hrf_validation.cif.gz | 26.4 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/hr/1hrf ftp://data.pdbj.org/pub/pdb/validation_reports/hr/1hrf | HTTPS FTP |
-Related structure data
-Links
-Assembly
Deposited unit |
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1 |
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NMR ensembles |
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-Components
#1: Protein | Mass: 7544.686 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / References: UniProt: Q02297 |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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-Sample preparation
Crystal grow | *PLUS Method: other / Details: NMR |
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-Processing
Software |
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NMR software | Name: X-PLOR / Developer: BRUNGER / Classification: refinement | ||||||||
NMR ensemble | Conformers submitted total number: 10 |