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Yorodumi- PDB-1hpk: SOLUTION NMR STRUCTURE OF THE HUMAN PLASMINOGEN KRINGLE 1 DOMAIN ... -
+Open data
-Basic information
Entry | Database: PDB / ID: 1hpk | |||||||||
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Title | SOLUTION NMR STRUCTURE OF THE HUMAN PLASMINOGEN KRINGLE 1 DOMAIN COMPLEXED WITH 6-AMINOHEXANOIC ACID AT PH 5.3, 310K, DERIVED FROM RANDOMLY GENERATED STRUCTURES USING SIMULATED ANNEALING, MINIMIZED AVERAGE STRUCTURE | |||||||||
Components | PLASMINOGEN | |||||||||
Keywords | SERINE PROTEASE / FIBRINOLYTIC ENZYME / LYSINE-BINDING DOMAIN | |||||||||
Function / homology | Function and homology information plasmin / trans-synaptic signaling by BDNF, modulating synaptic transmission / trophoblast giant cell differentiation / tissue remodeling / protein antigen binding / tissue regeneration / mononuclear cell migration / Signaling by PDGF / negative regulation of cell-cell adhesion mediated by cadherin / positive regulation of fibrinolysis ...plasmin / trans-synaptic signaling by BDNF, modulating synaptic transmission / trophoblast giant cell differentiation / tissue remodeling / protein antigen binding / tissue regeneration / mononuclear cell migration / Signaling by PDGF / negative regulation of cell-cell adhesion mediated by cadherin / positive regulation of fibrinolysis / Dissolution of Fibrin Clot / negative regulation of cell-substrate adhesion / myoblast differentiation / biological process involved in interaction with symbiont / labyrinthine layer blood vessel development / muscle cell cellular homeostasis / Activation of Matrix Metalloproteinases / apolipoprotein binding / extracellular matrix disassembly / positive regulation of blood vessel endothelial cell migration / negative regulation of fibrinolysis / fibrinolysis / Degradation of the extracellular matrix / serine-type peptidase activity / platelet alpha granule lumen / kinase binding / Schaffer collateral - CA1 synapse / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / blood coagulation / Platelet degranulation / protein-folding chaperone binding / endopeptidase activity / protease binding / collagen-containing extracellular matrix / blood microparticle / protein domain specific binding / negative regulation of cell population proliferation / external side of plasma membrane / serine-type endopeptidase activity / signaling receptor binding / glutamatergic synapse / enzyme binding / cell surface / proteolysis / extracellular space / extracellular exosome / extracellular region / plasma membrane Similarity search - Function | |||||||||
Biological species | Homo sapiens (human) | |||||||||
Method | SOLUTION NMR | |||||||||
Authors | Rejante, M. / Llinas, M. | |||||||||
Citation | Journal: Eur.J.Biochem. / Year: 1994 Title: Solution structure of the epsilon-aminohexanoic acid complex of human plasminogen kringle 1. Authors: Rejante, M.R. / Llinas, M. #1: Journal: Eur.J.Biochem. / Year: 1994 Title: 1H-NMR Assignments and Secondary Structure of Human Plasminogen Kringle 1 Authors: Rejante, M.R. / Llinas, M. | |||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 1hpk.cif.gz | 36.8 KB | Display | PDBx/mmCIF format |
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PDB format | pdb1hpk.ent.gz | 24.2 KB | Display | PDB format |
PDBx/mmJSON format | 1hpk.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 1hpk_validation.pdf.gz | 356.1 KB | Display | wwPDB validaton report |
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Full document | 1hpk_full_validation.pdf.gz | 366.9 KB | Display | |
Data in XML | 1hpk_validation.xml.gz | 4.9 KB | Display | |
Data in CIF | 1hpk_validation.cif.gz | 6.2 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/hp/1hpk ftp://data.pdbj.org/pub/pdb/validation_reports/hp/1hpk | HTTPS FTP |
-Related structure data
-Links
-Assembly
Deposited unit |
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1 |
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NMR ensembles |
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-Components
#1: Protein | Mass: 9076.989 Da / Num. of mol.: 1 / Fragment: KRINGLE 1 DOMAIN / Source method: isolated from a natural source / Details: CONTAINS THE 6-AMINOHEXANOIC ACID LIGAND / Source: (natural) Homo sapiens (human) / Organ: BLOOD / Tissue: BLOOD PLASMA / References: UniProt: P00747, plasmin |
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#2: Chemical | ChemComp-ACA / |
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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-Sample preparation
Sample conditions | pH: 5.3 / Temperature: 310 K |
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Crystal grow | *PLUS Method: other / Details: NMR |
-NMR measurement
NMR spectrometer | Type: Bruker AM 500 / Manufacturer: Bruker / Model: AM 500 / Field strength: 500 MHz |
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-Processing
Software |
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NMR software | Name: X-PLOR / Version: 3.1 / Developer: BRUNGER / Classification: refinement | ||||||||||||
NMR ensemble | Conformer selection criteria: MINIMIZED AVERAGE / Conformers submitted total number: 1 |