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- PDB-1hp2: SOLUTION STRUCTURE OF A TOXIN FROM THE SCORPION TITYUS SERRULATUS... -
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Open data
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Basic information
Entry | Database: PDB / ID: 1hp2 | ||||||
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Title | SOLUTION STRUCTURE OF A TOXIN FROM THE SCORPION TITYUS SERRULATUS (TSTX-K ALPHA) DETERMINED BY NMR. | ||||||
![]() | TITYUSTOXIN K ALPHA | ||||||
![]() | TOXIN / K+ channel / scorpion toxin / alpha-K toxin | ||||||
Function / homology | Scorpion short toxins signature. / Scorpion short chain toxin, potassium channel inhibitor / Scorpion short toxin, BmKK2 / Knottin, scorpion toxin-like superfamily / ion channel inhibitor activity / : / toxin activity / extracellular region / Potassium channel toxin alpha-KTx 4.1![]() | ||||||
Biological species | ![]() | ||||||
Method | SOLUTION NMR / distance geometry simulated annealing | ||||||
![]() | Ellis, K.C. / Tenenholz, T.C. / Gilly, W.F. / Blaustein, M.P. / Weber, D.J. | ||||||
![]() | ![]() Title: Interaction of a toxin from the scorpion Tityus serrulatus with a cloned K+ channel from squid (sqKv1A). Authors: Ellis, K.C. / Tenenholz, T.C. / Jerng, H. / Hayhurst, M. / Dudlak, C.S. / Gilly, W.F. / Blaustein, M.P. / Weber, D.J. #1: ![]() Title: Polypeptide Toxins from the Venoms of Old World and New World Scorpions Preferentially Block Different Potassium Channels Authors: Blaustein, M.P. / Rogowski, R.S. / Schneider, M.J. / Krueger, B.K. | ||||||
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 315.2 KB | Display | ![]() |
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PDB format | ![]() | 275.9 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
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-Validation report
Summary document | ![]() | 341.7 KB | Display | ![]() |
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Full document | ![]() | 534.2 KB | Display | |
Data in XML | ![]() | 25.2 KB | Display | |
Data in CIF | ![]() | 39 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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NMR ensembles |
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Components
#1: Protein/peptide | Mass: 3955.845 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR | ||||||||||||||||||||||||||||||||||||||||||||
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NMR experiment |
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NMR details | Text: This structure was determined using standard 2D homonuclear techniques. |
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Sample preparation
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Sample conditions |
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Crystal grow | *PLUS Method: other / Details: NMR |
-NMR measurement
NMR spectrometer | Type: Bruker DMX / Manufacturer: Bruker / Model: DMX / Field strength: 600 MHz |
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Processing
NMR software |
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Refinement | Method: distance geometry simulated annealing / Software ordinal: 1 Details: These structures are based on a total of 569 NOE distance contraints, 13 dihedral angle restraints, and 16 phi angle restraints. | ||||||||||||||||||||||||
NMR representative | Selection criteria: closest to the average | ||||||||||||||||||||||||
NMR ensemble | Conformer selection criteria: structures with acceptable covalent geometry,structures with the least restraint violations,structures with the lowest energy Conformers calculated total number: 100 / Conformers submitted total number: 30 |