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データを開く
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基本情報
登録情報 | データベース: PDB / ID: 1hmc | ||||||
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タイトル | THREE-DIMENSIONAL STRUCTURE OF DIMERIC HUMAN RECOMBINANT MACROPHAGE COLONY STIMULATING FACTOR | ||||||
![]() | HUMAN MACROPHAGE COLONY STIMULATING FACTOR | ||||||
![]() | MACROPHAGE COLONY STIMULATING FACTOR | ||||||
機能・相同性 | ![]() regulation of macrophage derived foam cell differentiation / mammary gland fat development / positive regulation of macrophage colony-stimulating factor signaling pathway / macrophage homeostasis / monocyte activation / macrophage colony-stimulating factor receptor binding / monocyte homeostasis / osteoclast proliferation / positive regulation of macrophage migration / developmental process involved in reproduction ...regulation of macrophage derived foam cell differentiation / mammary gland fat development / positive regulation of macrophage colony-stimulating factor signaling pathway / macrophage homeostasis / monocyte activation / macrophage colony-stimulating factor receptor binding / monocyte homeostasis / osteoclast proliferation / positive regulation of macrophage migration / developmental process involved in reproduction / positive regulation of odontogenesis of dentin-containing tooth / CSF1-CSF1R complex / macrophage colony-stimulating factor signaling pathway / positive regulation of microglial cell migration / mammary duct terminal end bud growth / microglial cell proliferation / positive regulation of macrophage differentiation / positive regulation of macrophage derived foam cell differentiation / positive regulation of mononuclear cell proliferation / myeloid leukocyte migration / neutrophil homeostasis / positive regulation of multicellular organism growth / positive regulation of monocyte differentiation / positive regulation of osteoclast differentiation / positive regulation of Ras protein signal transduction / branching involved in mammary gland duct morphogenesis / positive regulation of cell-matrix adhesion / Other interleukin signaling / positive regulation of macrophage chemotaxis / Interleukin-10 signaling / monocyte differentiation / macrophage differentiation / regulation of ossification / positive regulation of protein kinase activity / homeostasis of number of cells within a tissue / cell surface receptor protein tyrosine kinase signaling pathway / positive regulation of protein metabolic process / osteoclast differentiation / cytokine activity / response to ischemia / Post-translational protein phosphorylation / growth factor activity / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / Signaling by CSF1 (M-CSF) in myeloid cells / Ras protein signal transduction / nuclear body / positive regulation of cell migration / inflammatory response / endoplasmic reticulum lumen / innate immune response / positive regulation of cell population proliferation / positive regulation of gene expression / perinuclear region of cytoplasm / protein homodimerization activity / extracellular space / extracellular region / identical protein binding / membrane / plasma membrane 類似検索 - 分子機能 | ||||||
生物種 | ![]() | ||||||
手法 | ![]() | ||||||
![]() | Bohm, A. / Pandit, J. / Jancarik, J. / Halenbeck, R. / Koths, K. / Kim, S.-H. | ||||||
![]() | ![]() タイトル: Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor. 著者: Pandit, J. / Bohm, A. / Jancarik, J. / Halenbeck, R. / Koths, K. / Kim, S.H. | ||||||
履歴 |
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構造の表示
構造ビューア | 分子: ![]() ![]() |
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ダウンロードとリンク
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ダウンロード
PDBx/mmCIF形式 | ![]() | 21.2 KB | 表示 | ![]() |
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PDB形式 | ![]() | 10.5 KB | 表示 | ![]() |
PDBx/mmJSON形式 | ![]() | ツリー表示 | ![]() | |
その他 | ![]() |
-検証レポート
文書・要旨 | ![]() | 310.7 KB | 表示 | ![]() |
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文書・詳細版 | ![]() | 310.8 KB | 表示 | |
XML形式データ | ![]() | 735 B | 表示 | |
CIF形式データ | ![]() | 3.3 KB | 表示 | |
アーカイブディレクトリ | ![]() ![]() | HTTPS FTP |
-関連構造データ
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リンク
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集合体
登録構造単位 | ![]()
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単位格子 |
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非結晶学的対称性 (NCS) | NCS oper: (Code: given Matrix: (-0.925055, -0.377203, -0.043564), ベクター: 詳細 | THE TRANSFORMATION PRESENTED ON *MTRIX* RECORDS BELOW WILL YIELD APPROXIMATE COORDINATES FOR CHAIN A WHEN APPLIED TO CHAIN B. | |
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要素
#1: タンパク質 | 分子量: 17292.590 Da / 分子数: 2 / 由来タイプ: 組換発現 / 由来: (組換発現) ![]() 配列の詳細 | SEQUENCE ADVISORY NOTICE: DIFFERENCE BETWEEN SWISS-PROT AND PDB SEQUENCE. SWISS-PROT ENTRY NAME: : ...SEQUENCE ADVISORY NOTICE: DIFFERENCE | |
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-実験情報
-実験
実験 | 手法: ![]() |
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試料調製
結晶 | マシュー密度: 2.47 Å3/Da / 溶媒含有率: 50.11 % | ||||||||||||||||||||||||||||||
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結晶化 | *PLUS 手法: 蒸気拡散法 | ||||||||||||||||||||||||||||||
溶液の組成 | *PLUS
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-データ収集
放射 | 散乱光タイプ: x-ray |
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放射波長 | 相対比: 1 |
反射 | *PLUS 最高解像度: 2 Å / Num. obs: 18842 / Num. measured all: 65871 / Rmerge(I) obs: 0.0701 |
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解析
ソフトウェア |
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精密化 | 解像度: 2.5→8 Å / Rfactor Rwork: 0.197 / Rfactor obs: 0.197 / σ(F): 2 詳細: THE SEQUENCE THAT WAS CRYSTALLIZED RAN FROM RESIDUE 4 THROUGH RESIDUE 158. NEITHER OF THE TWO TERMINI COULD BE LOCATED IN THE ELECTRON DENSITY MAPS. THE TWO CRYSTALLOGRAPHICALLY UNIQUE ...詳細: THE SEQUENCE THAT WAS CRYSTALLIZED RAN FROM RESIDUE 4 THROUGH RESIDUE 158. NEITHER OF THE TWO TERMINI COULD BE LOCATED IN THE ELECTRON DENSITY MAPS. THE TWO CRYSTALLOGRAPHICALLY UNIQUE MONOMERS HAVE BEEN ASSIGNED CHAIN INDICATORS *A* AND *B*. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
精密化ステップ | サイクル: LAST / 解像度: 2.5→8 Å
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拘束条件 |
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ソフトウェア | *PLUS 名称: ![]() | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
精密化 | *PLUS 最高解像度: 2.5 Å / 最低解像度: 8 Å / σ(F): 2 / Rfactor obs: 0.197 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
溶媒の処理 | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
原子変位パラメータ | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
拘束条件 | *PLUS タイプ: x_angle_d / Dev ideal: 3.7 |