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Open data
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Basic information
Entry | Database: PDB / ID: 1hhw | ||||||
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Title | Solution structure of LNA1:RNA hybrid | ||||||
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![]() | ANTISENSE / LOCKED NUCLEIC ACID / DNA / RNA / HYBRID / RNASE H | ||||||
Function / homology | DNA/RNA hybrid / RNA![]() | ||||||
Method | SOLUTION NMR / simulated annealing | ||||||
![]() | Petersen, M. / Bondensgaard, K. / Wengel, J. / Jacobsen, J.P. | ||||||
![]() | ![]() Title: Locked Nucleic Acid (Lna) Recognition of RNA: NMR Solution Structures of Lna:RNA Hybrids Authors: Petersen, M. / Bondensgaard, K. / Wengel, J. / Jacobsen, J.P. #1: ![]() Title: Origin of Locked Nucleic Acid High-Affinity Recognition of RNA as Revealed by High-Resolution NMR Structures Authors: Petersen, M. / Bondensgaard, K. / Wengel, J. / Jacobsen, J.P. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 454.5 KB | Display | ![]() |
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PDB format | ![]() | 374.4 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 340.1 KB | Display | ![]() |
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Full document | ![]() | 673.8 KB | Display | |
Data in XML | ![]() | 17.2 KB | Display | |
Data in CIF | ![]() | 30 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
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Links
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Assembly
Deposited unit | ![]()
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1 |
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NMR ensembles |
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Components
#1: DNA/RNA hybrid | Mass: 2758.821 Da / Num. of mol.: 1 / Source method: obtained synthetically |
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#2: RNA chain | Mass: 2855.767 Da / Num. of mol.: 1 / Source method: obtained synthetically |
Sequence details | CHAIN A RESIDUE 5 IS A LOCKED NUCLEIC ACID OR (1R,3R,4R,7S) -7-HYDROXY-1-HYDROXYMETHYL-3-(THYMIN-1- ...CHAIN A RESIDUE 5 IS A LOCKED NUCLEIC ACID OR (1R,3R,4R,7S) -7-HYDROXY-1-HYDROXYMET |
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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NMR experiment | Type: NOESY |
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Sample preparation
Sample conditions | Ionic strength: 0.1 / pH: 7.0 / Pressure: 1 atm / Temperature: 298 K |
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Crystal grow | *PLUS Method: other / Details: NMR |
-NMR measurement
NMR spectrometer | Type: Varian INOVA / Manufacturer: Varian / Model: INOVA / Field strength: 750 MHz |
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Processing
NMR software |
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Refinement | Method: simulated annealing / Software ordinal: 1 Details: A TOTAL OF 284 NOE DISTANCE RESTRAINTS WERE OBTAINED FROM A FULL RELAXATION MATRIX ANALYSIS WITH THE PROGRAM RANDMARDI. 16 J-COUPLING CONSTANT RESTRAINTS WERE DERIVED FROM A J-SCALED-1H-31P- ...Details: A TOTAL OF 284 NOE DISTANCE RESTRAINTS WERE OBTAINED FROM A FULL RELAXATION MATRIX ANALYSIS WITH THE PROGRAM RANDMARDI. 16 J-COUPLING CONSTANT RESTRAINTS WERE DERIVED FROM A J-SCALED-1H-31P-HMBC SPECTRUM. 22 WATSON-CRICK BASE PAIRING RESTRAINTS. | |||||||||||||||
NMR ensemble | Conformers calculated total number: 40 / Conformers submitted total number: 40 |