登録情報 データベース : PDB / ID : 1gq5 構造の表示 ダウンロードとリンクタイトル Structural Determinants of the NHERF Interaction with beta2-AR and PDGFR 要素EZRIN-RADIXIN-MOESIN BINDING PHOSPHOPROTEIN-50 詳細 キーワード SIGNALING PROTEIN / PDZ / BETA2-ADRENERGIC RECEPTOR / PDGFR / NHERF / COMPLEX機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
platelet activating factor receptor activity / platelet-derived growth factor receptor activity / platelet-derived growth factor beta-receptor activity / cell migration involved in coronary angiogenesis / metanephric glomerular mesangial cell proliferation involved in metanephros development / positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway / smooth muscle cell chemotaxis / import across plasma membrane / channel activator activity / regulation of renal phosphate excretion ... platelet activating factor receptor activity / platelet-derived growth factor receptor activity / platelet-derived growth factor beta-receptor activity / cell migration involved in coronary angiogenesis / metanephric glomerular mesangial cell proliferation involved in metanephros development / positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway / smooth muscle cell chemotaxis / import across plasma membrane / channel activator activity / regulation of renal phosphate excretion / renal sodium ion transport / type 2 metabotropic glutamate receptor binding / glutathione transport / metanephric glomerular capillary formation / dopamine receptor binding / renal phosphate ion absorption / gamma-aminobutyric acid transmembrane transporter activity / gamma-aminobutyric acid import / cerebrospinal fluid circulation / cell migration involved in vasculogenesis / microvillus assembly / positive regulation of monoatomic ion transmembrane transport / aorta morphogenesis / negative regulation of sodium ion transport / bile acid secretion / positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway / platelet-derived growth factor binding / maintenance of epithelial cell apical/basal polarity / plasma membrane organization / stereocilium tip / intracellular phosphate ion homeostasis / cilium organization / vascular endothelial growth factor binding / retina vasculature development in camera-type eye / cardiac myofibril assembly / gland morphogenesis / myosin II binding / phosphatidylinositol metabolic process / phospholipase C-activating dopamine receptor signaling pathway / growth factor receptor binding / establishment of Golgi localization / fibroblast migration / positive regulation of chemotaxis / Signaling by PDGF / type 3 metabotropic glutamate receptor binding / plasma membrane protein complex / establishment of epithelial cell apical/basal polarity / platelet-derived growth factor receptor binding / negative regulation of fibroblast migration / negative regulation of platelet-derived growth factor receptor signaling pathway / chloride channel regulator activity / auditory receptor cell stereocilium organization / nuclear migration / regulation of protein kinase activity / microvillus membrane / regulation of cell size / positive regulation of DNA biosynthetic process / renal absorption / positive regulation of smooth muscle cell migration / positive regulation of calcium ion import / platelet-derived growth factor receptor-beta signaling pathway / positive regulation of phosphoprotein phosphatase activity / microvillus / transport across blood-brain barrier / platelet-derived growth factor receptor signaling pathway / negative regulation of mitotic cell cycle / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / phosphatase binding / endomembrane system / : / positive regulation of calcium-mediated signaling / beta-2 adrenergic receptor binding / positive regulation of intrinsic apoptotic signaling pathway / protein-membrane adaptor activity / sperm midpiece / ruffle / Downstream signal transduction / positive regulation of mitotic nuclear division / lysosomal lumen / cell chemotaxis / filopodium / protein localization to plasma membrane / cell periphery / PDZ domain binding / morphogenesis of an epithelium / brush border membrane / regulation of actin cytoskeleton organization / sensory perception of sound / positive regulation of smooth muscle cell proliferation / positive regulation of MAP kinase activity / negative regulation of canonical Wnt signaling pathway / negative regulation of ERK1 and ERK2 cascade / receptor protein-tyrosine kinase / beta-catenin binding / Wnt signaling pathway / adenylate cyclase-activating dopamine receptor signaling pathway / peptidyl-tyrosine phosphorylation / Constitutive Signaling by Aberrant PI3K in Cancer / positive regulation of reactive oxygen species metabolic process / : 類似検索 - 分子機能 Platelet-derived growth factor receptor beta / EBP50, C-terminal / Na(+)/H(+) exchange regulatory cofactor NHERF-1/2 / EBP50, C-terminal / Tyrosine-protein kinase, receptor class III, conserved site / Receptor tyrosine kinase class III signature. / PDZ domain / Pdz3 Domain / Immunoglobulin / Immunoglobulin domain ... Platelet-derived growth factor receptor beta / EBP50, C-terminal / Na(+)/H(+) exchange regulatory cofactor NHERF-1/2 / EBP50, C-terminal / Tyrosine-protein kinase, receptor class III, conserved site / Receptor tyrosine kinase class III signature. / PDZ domain / Pdz3 Domain / Immunoglobulin / Immunoglobulin domain / Immunoglobulin domain / PDZ domain / PDZ domain profile. / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Immunoglobulin subtype / Immunoglobulin / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Roll / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Mainly Beta 類似検索 - ドメイン・相同性 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 / Platelet-derived growth factor receptor beta 類似検索 - 構成要素生物種 HOMO SAPIENS (ヒト)手法 X線回折 / 分子置換 / 解像度 : 2.2 Å 詳細データ登録者 Karthikeyan, S. / Leung, T. / Ladias, J.A.A. 引用 残り2件を表示 表示を減らす履歴 登録 2001年11月20日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2002年11月14日 Provider : repository / タイプ : Initial release改定 1.1 2011年5月8日 Group : Version format compliance改定 1.2 2011年7月13日 Group : Version format compliance改定 1.3 2023年12月13日 Group : Data collection / Database references ... Data collection / Database references / Other / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf
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