登録情報 データベース : PDB / ID : 1gmy 構造の表示 ダウンロードとリンクタイトル Cathepsin B complexed with dipeptidyl nitrile inhibitor 要素CATHEPSIN B 詳細 キーワード HYDROLASE/INHIBITOR / COMPLEX (HYDROLASE-INHIBITOR) / COVALENT COMPLEX / PROTEASE / CATHEPSIN B / HYDROLASE / THIOL PROTEASE / HYDROLASE-INHIBITOR complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
cathepsin B / peptidase inhibitor complex / thyroid hormone generation / endolysosome lumen / cellular response to thyroid hormone stimulus / Trafficking and processing of endosomal TLR / proteoglycan binding / Assembly of collagen fibrils and other multimeric structures / Collagen degradation / decidualization ... cathepsin B / peptidase inhibitor complex / thyroid hormone generation / endolysosome lumen / cellular response to thyroid hormone stimulus / Trafficking and processing of endosomal TLR / proteoglycan binding / Assembly of collagen fibrils and other multimeric structures / Collagen degradation / decidualization / collagen catabolic process / epithelial cell differentiation / cysteine-type peptidase activity / collagen binding / MHC class II antigen presentation / proteolysis involved in protein catabolic process / melanosome / peptidase activity / collagen-containing extracellular matrix / regulation of apoptotic process / ficolin-1-rich granule lumen / lysosome / symbiont entry into host cell / apical plasma membrane / external side of plasma membrane / cysteine-type endopeptidase activity / Neutrophil degranulation / perinuclear region of cytoplasm / proteolysis / extracellular space / extracellular exosome / extracellular region 類似検索 - 分子機能 Peptidase C1A, propeptide / Peptidase family C1 propeptide / Cysteine peptidase, asparagine active site / Eukaryotic thiol (cysteine) proteases asparagine active site. / Cysteine peptidase, histidine active site / Eukaryotic thiol (cysteine) proteases histidine active site. / : / Peptidase C1A, papain C-terminal / Papain family cysteine protease / Papain family cysteine protease ... Peptidase C1A, propeptide / Peptidase family C1 propeptide / Cysteine peptidase, asparagine active site / Eukaryotic thiol (cysteine) proteases asparagine active site. / Cysteine peptidase, histidine active site / Eukaryotic thiol (cysteine) proteases histidine active site. / : / Peptidase C1A, papain C-terminal / Papain family cysteine protease / Papain family cysteine protease / Cysteine proteinases / Cysteine peptidase, cysteine active site / Eukaryotic thiol (cysteine) proteases cysteine active site. / Cathepsin B; Chain A / Papain-like cysteine peptidase superfamily / Alpha-Beta Complex / Alpha Beta 類似検索 - ドメイン・相同性 2-AMINOETHANIMIDIC ACID / 3-METHYLPHENYLALANINE / DIPHENYLACETIC ACID / Cathepsin B 類似検索 - 構成要素生物種 HOMO SAPIENS (ヒト)手法 X線回折 / 分子置換 / 解像度 : 1.9 Å 詳細データ登録者 Greenspan, P.D. / Clark, K.L. / Tommasi, R.A. / Cowen, S.D. / McQuire, L.W. / Farley, D.L. / van Duzer, J.H. / Goldberg, R.L. / Zhou, H. / Du, Z. ...Greenspan, P.D. / Clark, K.L. / Tommasi, R.A. / Cowen, S.D. / McQuire, L.W. / Farley, D.L. / van Duzer, J.H. / Goldberg, R.L. / Zhou, H. / Du, Z. / Fitt, J.J. / Coppa, D.E. / Fang, Z. / Macchia, W. / Zhu, L. / Capparelli, M.P. / Goldstein, R. / Wigg, A.M. / Doughty, J.R. / Bohacek, R.S. / Knap, A.K. 引用ジャーナル : J.Med.Chem. / 年 : 2001タイトル : Identification of Dipeptidyl Nitriles as Potent and Selective Inhibitors of Cathepsin B Through Structure-Based Drug Design著者: Greenspan, P.D. / Clark, K.L. / Tommasi, R.A. / Cowen, S.D. / Mcquire, L.W. / Farley, D.L. / Van Duzer, J.H. / Goldberg, R.L. / Zhou, H. / Du, Z. / Fitt, J.J. / Coppa, D.E. / Fang, Z. / ... 著者 : Greenspan, P.D. / Clark, K.L. / Tommasi, R.A. / Cowen, S.D. / Mcquire, L.W. / Farley, D.L. / Van Duzer, J.H. / Goldberg, R.L. / Zhou, H. / Du, Z. / Fitt, J.J. / Coppa, D.E. / Fang, Z. / Macchia, W. / Zhu, L. / Capparelli, M.P. / Goldstein, R. / Wigg, A.M. / Doughty, J.R. / S Bohacek, R. / Knap, A.K. 履歴 登録 2001年9月25日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2002年9月19日 Provider : repository / タイプ : Initial release改定 1.1 2011年5月8日 Group : Version format compliance改定 1.2 2011年7月13日 Group : Version format compliance改定 1.3 2017年7月5日 Group : Data collection / カテゴリ : diffrn_source / Item : _diffrn_source.type
すべて表示 表示を減らす Remark 700 SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN ... SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN THE SHEET RECORDS BELOW, TWO SHEETS ARE DEFINED.