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- PDB-1gdc: REFINED SOLUTION STRUCTURE OF THE GLUCOCORTICOID RECEPTOR DNA-BIN... -
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Basic information
Entry | Database: PDB / ID: 1gdc | ||||||
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Title | REFINED SOLUTION STRUCTURE OF THE GLUCOCORTICOID RECEPTOR DNA-BINDING DOMAIN | ||||||
![]() | GLUCOCORTICOID RECEPTOR | ||||||
![]() | GLUCOCORTICOID RECEPTOR | ||||||
Function / homology | ![]() nuclear receptor-mediated corticosteroid signaling pathway / negative regulation of behavioral fear response / muscle atrophy / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / negative regulation of synaptic plasticity / positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway / nuclear receptor-mediated glucocorticoid signaling pathway / response to inactivity / negative regulation of long-term synaptic depression / regulation of glucocorticoid biosynthetic process ...nuclear receptor-mediated corticosteroid signaling pathway / negative regulation of behavioral fear response / muscle atrophy / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / negative regulation of synaptic plasticity / positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway / nuclear receptor-mediated glucocorticoid signaling pathway / response to inactivity / negative regulation of long-term synaptic depression / regulation of glucocorticoid biosynthetic process / nuclear glucocorticoid receptor activity / SUMOylation of intracellular receptors / positive regulation of cell growth involved in cardiac muscle cell development / steroid hormone binding / Nuclear Receptor transcription pathway / response to mercury ion / glucocorticoid metabolic process / response to cortisol / hormone binding / neuroinflammatory response / Leydig cell differentiation / mammary gland duct morphogenesis / microglia differentiation / cellular response to magnesium ion / maternal behavior / response to arsenic-containing substance / astrocyte differentiation / negative regulation of vascular permeability / positive regulation of glutamate secretion / adrenal gland development / regulation of gluconeogenesis / cellular response to glucocorticoid stimulus / response to corticosterone / cellular response to steroid hormone stimulus / response to dexamethasone / positive regulation of dendritic spine development / motor behavior / associative learning / androgen metabolic process / regulation of glucose metabolic process / response to electrical stimulus / estrogen response element binding / nuclear receptor-mediated steroid hormone signaling pathway / postsynaptic density, intracellular component / cellular response to transforming growth factor beta stimulus / core promoter sequence-specific DNA binding / heat shock protein binding / steroid binding / cellular response to dexamethasone stimulus / Hsp70 protein binding / transcription initiation-coupled chromatin remodeling / female pregnancy / TBP-class protein binding / positive regulation of cytokine production / response to activity / synaptic transmission, glutamatergic / RNA polymerase II transcription regulatory region sequence-specific DNA binding / lung development / Hsp90 protein binding / promoter-specific chromatin binding / response to insulin / receptor tyrosine kinase binding / positive regulation of miRNA transcription / response to wounding / DNA-binding transcription repressor activity, RNA polymerase II-specific / spindle / circadian rhythm / response to calcium ion / nuclear receptor activity / sequence-specific double-stranded DNA binding / positive regulation of neuron apoptotic process / regulation of cell population proliferation / DNA-binding transcription activator activity, RNA polymerase II-specific / protein-containing complex assembly / double-stranded DNA binding / dendritic spine / sequence-specific DNA binding / gene expression / transcription coactivator activity / nuclear speck / chromatin remodeling / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of DNA-templated transcription / centrosome / chromatin binding / regulation of DNA-templated transcription / regulation of transcription by RNA polymerase II / negative regulation of apoptotic process / protein-containing complex binding / protein kinase binding / chromatin / glutamatergic synapse / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / protein-containing complex / mitochondrion / DNA binding / zinc ion binding / identical protein binding Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | SOLUTION NMR | ||||||
![]() | Baumann, H. / Paulsen, K. / Kovacs, H. / Berglund, H. / Wright, A.P.H. / Gustafsson, J.-A. / Hard, T. | ||||||
![]() | ![]() Title: Refined solution structure of the glucocorticoid receptor DNA-binding domain. Authors: Baumann, H. / Paulsen, K. / Kovacs, H. / Berglund, H. / Wright, A.P. / Gustafsson, J.A. / Hard, T. #1: ![]() Title: Structure and Function of the DNA-Binding Domain of the Glucocorticoid Receptor and Other Members of the Nuclear Receptor Supergene Family Authors: Hard, T. / Gustafsson, J.-A. #2: ![]() Title: Backbone Dynamics of the Glucocorticoid Receptor DNA-Binding Domain Authors: Berglund, H. / Kovacs, H. / Dahlman-Wright, K. / Gustafsson, J.-A. / Hard, T. #3: ![]() Title: Crystallographic Analysis of the Interaction of the Glucocorticoid Receptor with DNA Authors: Luisi, B.F. / Xu, W.X. / Otwinowski, Z. / Freedman, L.P. / Yamamoto, K.R. / Sigler, P.B. #4: ![]() Title: 1H NMR Studies of the Glucocorticoid Receptor DNA-Binding Domain: Sequential Assignments and Identification of Secondary Structure Elements Authors: Hard, T. / Kellenbach, E. / Boelens, R. / Kaptein, R. / Dahlman, K. / Carlstedt-Duke, J. / Freedman, L.P. / Maler, B.A. / Hyde, E. / Gustafsson, J.-A. / Yamamoto, K.R. #5: ![]() Title: Solution Structure of the Glucocorticoid Receptor DNA-Binding Domain Authors: Hard, T. / Kellenbach, E. / Boelens, R. / Maler, B.A. / Dahlman, K. / Freedman, L.P. / Carlstedt-Duke, J. / Yamamoto, K.R. / Gustafsson, J.-A. / Kaptein, R. | ||||||
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Full document | ![]() | 290.2 KB | Display | |
Data in XML | ![]() | 2.8 KB | Display | |
Data in CIF | ![]() | 3.6 KB | Display | |
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-Related structure data
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Assembly
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NMR ensembles |
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Components
#1: Protein | Mass: 8075.503 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() |
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#2: Chemical |
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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Sample preparation
Crystal grow | *PLUS Method: other / Details: NMR |
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Processing
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NMR ensemble | Conformers submitted total number: 1 |