[English] 日本語
Yorodumi- PDB-2gda: REFINED SOLUTION STRUCTURE OF THE GLUCOCORTICOID RECEPTOR DNA-BIN... -
+Open data
-Basic information
Entry | Database: PDB / ID: 2gda | ||||||
---|---|---|---|---|---|---|---|
Title | REFINED SOLUTION STRUCTURE OF THE GLUCOCORTICOID RECEPTOR DNA-BINDING DOMAIN | ||||||
Components | GLUCOCORTICOID RECEPTOR | ||||||
Keywords | GLUCOCORTICOID RECEPTOR | ||||||
Function / homology | Function and homology information muscle atrophy / negative regulation of synaptic plasticity / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / positive regulation of glucocorticoid receptor signaling pathway / response to inactivity / nuclear receptor-mediated glucocorticoid signaling pathway / regulation of glucocorticoid biosynthetic process / nuclear glucocorticoid receptor activity / positive regulation of cell growth involved in cardiac muscle cell development / SUMOylation of intracellular receptors ...muscle atrophy / negative regulation of synaptic plasticity / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / positive regulation of glucocorticoid receptor signaling pathway / response to inactivity / nuclear receptor-mediated glucocorticoid signaling pathway / regulation of glucocorticoid biosynthetic process / nuclear glucocorticoid receptor activity / positive regulation of cell growth involved in cardiac muscle cell development / SUMOylation of intracellular receptors / response to mercury ion / Nuclear Receptor transcription pathway / hormone binding / steroid hormone binding / nucleus localization / neuroinflammatory response / glucocorticoid metabolic process / microglia differentiation / mammary gland duct morphogenesis / maternal behavior / cellular response to magnesium ion / response to arsenic-containing substance / astrocyte differentiation / negative regulation of vascular permeability / positive regulation of glutamate secretion / cellular response to glucocorticoid stimulus / motor behavior / adrenal gland development / regulation of gluconeogenesis / cellular response to steroid hormone stimulus / response to corticosterone / positive regulation of dendritic spine development / response to dexamethasone / androgen metabolic process / regulation of glucose metabolic process / postsynaptic density, intracellular component / estrogen response element binding / cellular response to dexamethasone stimulus / nuclear receptor-mediated steroid hormone signaling pathway / response to electrical stimulus / core promoter sequence-specific DNA binding / cellular response to transforming growth factor beta stimulus / heat shock protein binding / Hsp70 protein binding / steroid binding / TBP-class protein binding / transcription initiation-coupled chromatin remodeling / lung development / positive regulation of miRNA transcription / response to activity / synaptic transmission, glutamatergic / female pregnancy / RNA polymerase II transcription regulatory region sequence-specific DNA binding / DNA-binding transcription repressor activity, RNA polymerase II-specific / Hsp90 protein binding / response to calcium ion / response to insulin / circadian rhythm / receptor tyrosine kinase binding / nuclear receptor activity / spindle / positive regulation of neuron apoptotic process / sequence-specific double-stranded DNA binding / double-stranded DNA binding / regulation of cell population proliferation / gene expression / DNA-binding transcription activator activity, RNA polymerase II-specific / protein-containing complex assembly / sequence-specific DNA binding / transcription coactivator activity / dendritic spine / chromatin remodeling / nuclear speck / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of DNA-templated transcription / chromatin binding / centrosome / glutamatergic synapse / regulation of transcription by RNA polymerase II / chromatin / negative regulation of apoptotic process / regulation of DNA-templated transcription / protein-containing complex binding / protein kinase binding / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / protein-containing complex / mitochondrion / DNA binding / zinc ion binding / identical protein binding / membrane / nucleus / cytoplasm / cytosol Similarity search - Function | ||||||
Biological species | Rattus norvegicus (Norway rat) | ||||||
Method | SOLUTION NMR | ||||||
Authors | Baumann, H. / Paulsen, K. / Kovacs, H. / Berglund, H. / Wright, A.P.H. / Gustafsson, J.-A. / Hard, T. | ||||||
Citation | Journal: Biochemistry / Year: 1993 Title: Refined solution structure of the glucocorticoid receptor DNA-binding domain. Authors: Baumann, H. / Paulsen, K. / Kovacs, H. / Berglund, H. / Wright, A.P. / Gustafsson, J.A. / Hard, T. #1: Journal: Acc.Chem.Res. / Year: 1993 Title: Structure and Function of the DNA-Binding Domain of the Glucocorticoid Receptor and Other Members of the Nuclear Receptor Supergene Family Authors: Hard, T. / Gustafsson, J.-A. #2: Journal: Biochemistry / Year: 1992 Title: Backbone Dynamics of the Glucocorticoid Receptor DNA-Binding Domain Authors: Berglund, H. / Kovacs, H. / Dahlman-Wright, K. / Gustafsson, J.-A. / Hard, T. #3: Journal: Nature / Year: 1991 Title: Crystallographic Analysis of the Interaction of the Glucocorticoid Receptor with DNA Authors: Luisi, B.F. / Xu, W.X. / Otwinowski, Z. / Freedman, L.P. / Yamamoto, K.R. / Sigler, P.B. #4: Journal: Biochemistry / Year: 1990 Title: 1H NMR Studies of the Glucocorticoid Receptor DNA-Binding Domain: Sequential Assignments and Identification of Secondary Structure Elements Authors: Hard, T. / Kellenbach, E. / Boelens, R. / Kaptein, R. / Dahlman, K. / Carlstedt-Duke, J. / Freedman, L.P. / Maler, B.A. / Hyde, E. / Gustafsson, J.-A. / Yamamoto, K.R. #5: Journal: Science / Year: 1990 Title: Solution Structure of the Glucocorticoid Receptor DNA-Binding Domain Authors: Hard, T. / Kellenbach, E. / Boelens, R. / Maler, B.A. / Dahlman, K. / Freedman, L.P. / Carlstedt-Duke, J. / Yamamoto, K.R. / Gustafsson, J.-A. / Kaptein, R. | ||||||
History |
|
-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
---|
-Downloads & links
-Download
PDBx/mmCIF format | 2gda.cif.gz | 522.7 KB | Display | PDBx/mmCIF format |
---|---|---|---|---|
PDB format | pdb2gda.ent.gz | 434 KB | Display | PDB format |
PDBx/mmJSON format | 2gda.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 2gda_validation.pdf.gz | 356.4 KB | Display | wwPDB validaton report |
---|---|---|---|---|
Full document | 2gda_full_validation.pdf.gz | 498.6 KB | Display | |
Data in XML | 2gda_validation.xml.gz | 26.6 KB | Display | |
Data in CIF | 2gda_validation.cif.gz | 47.6 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/gd/2gda ftp://data.pdbj.org/pub/pdb/validation_reports/gd/2gda | HTTPS FTP |
-Related structure data
-Links
-Assembly
Deposited unit |
| |||||||||
---|---|---|---|---|---|---|---|---|---|---|
1 |
| |||||||||
Atom site foot note | 1: CYS 54 - PRO 55 MODEL 9 OMEGA = 216.77 PEPTIDE BOND DEVIATES SIGNIFICANTLY FROM TRANS CONFORMATION | |||||||||
NMR ensembles |
|
-Components
#1: Protein | Mass: 8075.503 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Rattus norvegicus (Norway rat) / References: UniProt: P06536 |
---|---|
#2: Chemical |
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
---|
-Sample preparation
Crystal grow | *PLUS Method: other / Details: NMR |
---|
-Processing
NMR software |
| |||||||||
---|---|---|---|---|---|---|---|---|---|---|
NMR ensemble | Conformers submitted total number: 24 |