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- PDB-2gda: REFINED SOLUTION STRUCTURE OF THE GLUCOCORTICOID RECEPTOR DNA-BIN... -
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Basic information
Entry | Database: PDB / ID: 2gda | ||||||
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Title | REFINED SOLUTION STRUCTURE OF THE GLUCOCORTICOID RECEPTOR DNA-BINDING DOMAIN | ||||||
![]() | GLUCOCORTICOID RECEPTOR | ||||||
![]() | GLUCOCORTICOID RECEPTOR | ||||||
Function / homology | ![]() muscle atrophy / negative regulation of synaptic plasticity / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / positive regulation of glucocorticoid receptor signaling pathway / response to inactivity / nuclear receptor-mediated glucocorticoid signaling pathway / regulation of glucocorticoid biosynthetic process / nuclear glucocorticoid receptor activity / positive regulation of cell growth involved in cardiac muscle cell development / SUMOylation of intracellular receptors ...muscle atrophy / negative regulation of synaptic plasticity / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / positive regulation of glucocorticoid receptor signaling pathway / response to inactivity / nuclear receptor-mediated glucocorticoid signaling pathway / regulation of glucocorticoid biosynthetic process / nuclear glucocorticoid receptor activity / positive regulation of cell growth involved in cardiac muscle cell development / SUMOylation of intracellular receptors / response to mercury ion / Nuclear Receptor transcription pathway / steroid hormone binding / nucleus localization / neuroinflammatory response / glucocorticoid metabolic process / hormone binding / microglia differentiation / mammary gland duct morphogenesis / maternal behavior / cellular response to magnesium ion / response to arsenic-containing substance / astrocyte differentiation / negative regulation of vascular permeability / positive regulation of glutamate secretion / cellular response to glucocorticoid stimulus / motor behavior / regulation of gluconeogenesis / adrenal gland development / cellular response to steroid hormone stimulus / response to corticosterone / positive regulation of dendritic spine development / response to dexamethasone / androgen metabolic process / regulation of glucose metabolic process / postsynaptic density, intracellular component / estrogen response element binding / response to electrical stimulus / nuclear receptor-mediated steroid hormone signaling pathway / core promoter sequence-specific DNA binding / transcription initiation-coupled chromatin remodeling / cellular response to transforming growth factor beta stimulus / heat shock protein binding / Hsp70 protein binding / TBP-class protein binding / steroid binding / cellular response to dexamethasone stimulus / response to activity / synaptic transmission, glutamatergic / female pregnancy / RNA polymerase II transcription regulatory region sequence-specific DNA binding / lung development / Hsp90 protein binding / response to insulin / receptor tyrosine kinase binding / DNA-binding transcription repressor activity, RNA polymerase II-specific / positive regulation of miRNA transcription / response to calcium ion / spindle / circadian rhythm / nuclear receptor activity / sequence-specific double-stranded DNA binding / positive regulation of neuron apoptotic process / regulation of cell population proliferation / gene expression / protein-containing complex assembly / double-stranded DNA binding / DNA-binding transcription activator activity, RNA polymerase II-specific / sequence-specific DNA binding / dendritic spine / transcription coactivator activity / nuclear speck / chromatin remodeling / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of DNA-templated transcription / centrosome / glutamatergic synapse / chromatin binding / protein-containing complex binding / regulation of DNA-templated transcription / regulation of transcription by RNA polymerase II / negative regulation of apoptotic process / protein kinase binding / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / protein-containing complex / mitochondrion / DNA binding / zinc ion binding / identical protein binding / membrane / nucleus / cytoplasm / cytosol Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | SOLUTION NMR | ||||||
![]() | Baumann, H. / Paulsen, K. / Kovacs, H. / Berglund, H. / Wright, A.P.H. / Gustafsson, J.-A. / Hard, T. | ||||||
![]() | ![]() Title: Refined solution structure of the glucocorticoid receptor DNA-binding domain. Authors: Baumann, H. / Paulsen, K. / Kovacs, H. / Berglund, H. / Wright, A.P. / Gustafsson, J.A. / Hard, T. #1: ![]() Title: Structure and Function of the DNA-Binding Domain of the Glucocorticoid Receptor and Other Members of the Nuclear Receptor Supergene Family Authors: Hard, T. / Gustafsson, J.-A. #2: ![]() Title: Backbone Dynamics of the Glucocorticoid Receptor DNA-Binding Domain Authors: Berglund, H. / Kovacs, H. / Dahlman-Wright, K. / Gustafsson, J.-A. / Hard, T. #3: ![]() Title: Crystallographic Analysis of the Interaction of the Glucocorticoid Receptor with DNA Authors: Luisi, B.F. / Xu, W.X. / Otwinowski, Z. / Freedman, L.P. / Yamamoto, K.R. / Sigler, P.B. #4: ![]() Title: 1H NMR Studies of the Glucocorticoid Receptor DNA-Binding Domain: Sequential Assignments and Identification of Secondary Structure Elements Authors: Hard, T. / Kellenbach, E. / Boelens, R. / Kaptein, R. / Dahlman, K. / Carlstedt-Duke, J. / Freedman, L.P. / Maler, B.A. / Hyde, E. / Gustafsson, J.-A. / Yamamoto, K.R. #5: ![]() Title: Solution Structure of the Glucocorticoid Receptor DNA-Binding Domain Authors: Hard, T. / Kellenbach, E. / Boelens, R. / Maler, B.A. / Dahlman, K. / Freedman, L.P. / Carlstedt-Duke, J. / Yamamoto, K.R. / Gustafsson, J.-A. / Kaptein, R. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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PDBx/mmCIF format | ![]() | 522.7 KB | Display | ![]() |
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-Validation report
Summary document | ![]() | 356.4 KB | Display | ![]() |
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Full document | ![]() | 498.6 KB | Display | |
Data in XML | ![]() | 26.6 KB | Display | |
Data in CIF | ![]() | 47.6 KB | Display | |
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-Related structure data
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Links
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Assembly
Deposited unit | ![]()
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Atom site foot note | 1: CYS 54 - PRO 55 MODEL 9 OMEGA = 216.77 PEPTIDE BOND DEVIATES SIGNIFICANTLY FROM TRANS CONFORMATION | |||||||||
NMR ensembles |
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Components
#1: Protein | Mass: 8075.503 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() |
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#2: Chemical |
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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Sample preparation
Crystal grow | *PLUS Method: other / Details: NMR |
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Processing
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NMR ensemble | Conformers submitted total number: 24 |