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データを開く
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基本情報
登録情報 | データベース: PDB / ID: 1g82 | |||||||||
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タイトル | STRUCTURE OF FIBROBLAST GROWTH FACTOR 9 | |||||||||
![]() | FIBROBLAST GROWTH FACTOR 9 | |||||||||
![]() | HORMONE/GROWTH FACTOR / Fibroblast Growth Factor / HORMONE-GROWTH FACTOR COMPLEX | |||||||||
機能・相同性 | ![]() regulation of timing of cell differentiation / positive regulation of activin receptor signaling pathway / negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching / positive regulation of reproductive process / Sertoli cell proliferation / Transcriptional regulation of testis differentiation / embryonic skeletal system development / FGFR3b ligand binding and activation / eye development / embryonic digestive tract development ...regulation of timing of cell differentiation / positive regulation of activin receptor signaling pathway / negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching / positive regulation of reproductive process / Sertoli cell proliferation / Transcriptional regulation of testis differentiation / embryonic skeletal system development / FGFR3b ligand binding and activation / eye development / embryonic digestive tract development / Signaling by activated point mutants of FGFR3 / FGFR3c ligand binding and activation / Phospholipase C-mediated cascade; FGFR3 / mesenchymal cell proliferation / fibroblast growth factor receptor binding / FGFR2c ligand binding and activation / Activated point mutants of FGFR2 / Phospholipase C-mediated cascade; FGFR2 / FGFR4 ligand binding and activation / Phospholipase C-mediated cascade; FGFR4 / male sex determination / activin receptor signaling pathway / Signaling by activated point mutants of FGFR1 / FGFR1c ligand binding and activation / Downstream signaling of activated FGFR1 / Phospholipase C-mediated cascade: FGFR1 / lung-associated mesenchyme development / positive regulation of smoothened signaling pathway / positive regulation of vascular associated smooth muscle cell migration / positive regulation of vascular endothelial growth factor receptor signaling pathway / embryonic limb morphogenesis / positive regulation of mesenchymal cell proliferation / cardiac muscle cell proliferation / smoothened signaling pathway / inner ear morphogenesis / PI-3K cascade:FGFR3 / negative regulation of Wnt signaling pathway / PI-3K cascade:FGFR2 / positive regulation of stem cell proliferation / PI-3K cascade:FGFR4 / PI-3K cascade:FGFR1 / positive regulation of cell division / PI3K Cascade / fibroblast growth factor receptor signaling pathway / canonical Wnt signaling pathway / chondrocyte differentiation / SHC-mediated cascade:FGFR3 / vascular endothelial growth factor receptor signaling pathway / SHC-mediated cascade:FGFR2 / SHC-mediated cascade:FGFR4 / SHC-mediated cascade:FGFR1 / FRS-mediated FGFR3 signaling / positive regulation of cardiac muscle cell proliferation / FRS-mediated FGFR2 signaling / FRS-mediated FGFR4 signaling / Signaling by FGFR3 in disease / regulation of cell migration / FRS-mediated FGFR1 signaling / positive regulation of vascular associated smooth muscle cell proliferation / Signaling by FGFR2 in disease / substantia nigra development / Signaling by FGFR1 in disease / stem cell proliferation / positive regulation of epithelial cell proliferation / Negative regulation of FGFR3 signaling / Negative regulation of FGFR2 signaling / Negative regulation of FGFR4 signaling / animal organ morphogenesis / Negative regulation of FGFR1 signaling / growth factor activity / lung development / osteoblast differentiation / protein import into nucleus / Constitutive Signaling by Aberrant PI3K in Cancer / male gonad development / positive regulation of canonical Wnt signaling pathway / PIP3 activates AKT signaling / cell-cell signaling / heparin binding / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / RAF/MAP kinase cascade / angiogenesis / cell differentiation / positive regulation of protein phosphorylation / positive regulation of cell population proliferation / positive regulation of gene expression / negative regulation of transcription by RNA polymerase II / signal transduction / extracellular space / extracellular region / cytoplasm 類似検索 - 分子機能 | |||||||||
生物種 | ![]() | |||||||||
手法 | ![]() ![]() ![]() | |||||||||
![]() | Hecht, H.J. / Adar, R. / Hofmann, B. / Bogin, O. / Weich, H. / Yayon, A. | |||||||||
![]() | ![]() タイトル: Structure of fibroblast growth factor 9 shows a symmetric dimer with unique receptor- and heparin-binding interfaces. 著者: Hecht, H.J. / Adar, R. / Hofmann, B. / Bogin, O. / Weich, H. / Yayon, A. | |||||||||
履歴 |
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構造の表示
構造ビューア | 分子: ![]() ![]() |
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ダウンロードとリンク
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ダウンロード
PDBx/mmCIF形式 | ![]() | 148.3 KB | 表示 | ![]() |
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PDB形式 | ![]() | 117.2 KB | 表示 | ![]() |
PDBx/mmJSON形式 | ![]() | ツリー表示 | ![]() | |
その他 | ![]() |
-検証レポート
文書・要旨 | ![]() | 1.6 MB | 表示 | ![]() |
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文書・詳細版 | ![]() | 1.6 MB | 表示 | |
XML形式データ | ![]() | 32.5 KB | 表示 | |
CIF形式データ | ![]() | 43.3 KB | 表示 | |
アーカイブディレクトリ | ![]() ![]() | HTTPS FTP |
-関連構造データ
関連構造データ | ![]() 2afgS S: 精密化の開始モデル |
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類似構造データ |
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リンク
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集合体
登録構造単位 | ![]()
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2 | ![]()
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3 | ![]()
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4 |
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単位格子 |
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詳細 | the biological assembly is a dimer. The asymmetric unit contains two dimers. The dimers are formed by molecule A and D, and B and C. |
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要素
#1: タンパク質 | 分子量: 18614.072 Da / 分子数: 4 / 由来タイプ: 組換発現 / 由来: (組換発現) ![]() ![]() #2: 多糖 | #3: 化合物 | ChemComp-SO4 / #4: 糖 | ChemComp-NAG / | #5: 水 | ChemComp-HOH / | |
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-実験情報
-実験
実験 | 手法: ![]() |
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試料調製
結晶 | マシュー密度: 4.54 Å3/Da / 溶媒含有率: 72.92 % | ||||||||||||||||||||
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結晶化 | 温度: 292 K / 手法: 蒸気拡散法, シッティングドロップ法 / pH: 5.2 詳細: Ammonium sulfate, MES, TRIS, pH 5.2, VAPOR DIFFUSION, SITTING DROP, temperature 292K | ||||||||||||||||||||
結晶化 | *PLUS | ||||||||||||||||||||
溶液の組成 | *PLUS
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-データ収集
回折 | 平均測定温度: 100 K |
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放射光源 | 由来: ![]() ![]() |
検出器 | タイプ: MARRESEARCH / 検出器: CCD / 日付: 1998年12月22日 / 詳細: mirrors |
放射 | モノクロメーター: Si 111 / プロトコル: SINGLE WAVELENGTH / 単色(M)・ラウエ(L): M / 散乱光タイプ: x-ray |
放射波長 | 波長: 1.07 Å / 相対比: 1 |
反射 | 解像度: 2.6→39.5 Å / Num. all: 40985 / Num. obs: 40985 / % possible obs: 99.9 % / Observed criterion σ(F): 0 / Observed criterion σ(I): 0 / 冗長度: 6.3 % / Biso Wilson estimate: 68.211 Å2 / Rmerge(I) obs: 0.057 / Rsym value: 0.052 / Net I/σ(I): 8.5 |
反射 シェル | 解像度: 2.6→2.74 Å / 冗長度: 6.3 % / Rmerge(I) obs: 0.242 / Mean I/σ(I) obs: 3.3 / Num. unique all: 5971 / Rsym value: 0.222 / % possible all: 100 |
反射 | *PLUS |
反射 シェル | *PLUS % possible obs: 99.9 % |
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解析
ソフトウェア |
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精密化 | 構造決定の手法: ![]() 開始モデル: pdb entry 2AFG 解像度: 2.6→50 Å / Isotropic thermal model: Isotropic / 交差検証法: THROUGHOUT / σ(F): 0 / σ(I): 0 / 立体化学のターゲット値: Engh & Huber
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原子変位パラメータ | Biso mean: 51.97 Å2
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Refine analyze |
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精密化ステップ | サイクル: LAST / 解像度: 2.6→50 Å
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拘束条件 |
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ソフトウェア | *PLUS 名称: REFMAC / 分類: refinement | |||||||||||||||||||||||||
精密化 | *PLUS 最高解像度: 2.6 Å / σ(F): 0 / % reflection Rfree: 5 % | |||||||||||||||||||||||||
溶媒の処理 | *PLUS | |||||||||||||||||||||||||
原子変位パラメータ | *PLUS | |||||||||||||||||||||||||
拘束条件 | *PLUS タイプ: p_angle_d / Dev ideal: 2.7 |