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Open data
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Basic information
Entry | Database: PDB / ID: 1ftt | ||||||
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Title | THYROID TRANSCRIPTION FACTOR 1 HOMEODOMAIN (RATTUS NORVEGICUS) | ||||||
![]() | THYROID TRANSCRIPTION FACTOR 1 HOMEODOMAIN | ||||||
![]() | DNA BINDING PROTEIN / HOMEODOMAIN / TRANSCRIPTION FACTOR | ||||||
Function / homology | ![]() forebrain neuron fate commitment / cerebral cortex GABAergic interneuron differentiation / developmental induction / embryonic lung development / club cell differentiation / forebrain dorsal/ventral pattern formation / development of primary female sexual characteristics / type II pneumocyte differentiation / globus pallidus development / regulation of blood volume by renin-angiotensin ...forebrain neuron fate commitment / cerebral cortex GABAergic interneuron differentiation / developmental induction / embryonic lung development / club cell differentiation / forebrain dorsal/ventral pattern formation / development of primary female sexual characteristics / type II pneumocyte differentiation / globus pallidus development / regulation of blood volume by renin-angiotensin / lung saccule development / forebrain neuron differentiation / anatomical structure formation involved in morphogenesis / telencephalon cell migration / cerebral cortex neuron differentiation / hyperosmotic salinity response / pituitary gland development / intronic transcription regulatory region sequence-specific DNA binding / telencephalon development / neuron fate commitment / Leydig cell differentiation / pattern specification process / endoderm development / positive regulation of circadian rhythm / cellular response to leptin stimulus / negative regulation of epithelial to mesenchymal transition / feeding behavior / epithelial tube branching involved in lung morphogenesis / oligodendrocyte differentiation / cerebral cortex cell migration / thyroid gland development / phospholipid metabolic process / core promoter sequence-specific DNA binding / forebrain development / TBP-class protein binding / negative regulation of cell migration / response to hormone / locomotory behavior / hippocampus development / animal organ morphogenesis / RNA polymerase II transcription regulatory region sequence-specific DNA binding / axon guidance / negative regulation of transforming growth factor beta receptor signaling pathway / lung development / neuron migration / brain development / circadian rhythm / DNA-binding transcription activator activity, RNA polymerase II-specific / response to ethanol / transcription regulator complex / sequence-specific DNA binding / response to lipopolysaccharide / cell differentiation / transcription cis-regulatory region binding / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of DNA-templated transcription / positive regulation of gene expression / regulation of DNA-templated transcription / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / enzyme binding / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / DNA binding / nucleoplasm / identical protein binding / nucleus Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | SOLUTION NMR | ||||||
![]() | Fogolari, F. / Esposito, G. / Damante, G. / Formisano, S. / Di Lauro, R. / Viglino, P. | ||||||
![]() | ![]() Title: Analysis of the solution structure of the homeodomain of rat thyroid transcription factor 1 by 1H-NMR spectroscopy and restrained molecular mechanics. Authors: Esposito, G. / Fogolari, F. / Damante, G. / Formisano, S. / Tell, G. / Leonardi, A. / Di Lauro, R. / Viglino, P. #1: ![]() Title: Structural Study of Rat Thyroid Transcription Factor 1 Homeodomain (Ttf-1 Hd) by Nuclear Magnetic Resonance Authors: Viglino, P. / Fogolari, F. / Formisano, S. / Bortolotti, N. / Damante, G. / Di Lauro, R. / Esposito, G. | ||||||
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 477.5 KB | Display | ![]() |
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PDB format | ![]() | 402.1 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
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-Validation report
Summary document | ![]() | 344.3 KB | Display | ![]() |
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Full document | ![]() | 449.9 KB | Display | |
Data in XML | ![]() | 19.2 KB | Display | |
Data in CIF | ![]() | 34.3 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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1 |
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Atom site foot note | 1: LYS 61 - ASP 62 MODEL 5 OMEGA = 211.85 PEPTIDE BOND DEVIATES SIGNIFICANTLY FROM TRANS CONFORMATION | |||||||||
NMR ensembles |
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Components
#1: Protein | Mass: 8463.915 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Details: PH = 4.0 - 4.1, T = 287 - 289 K, NAN3 (W/V) = 0.2 - 0.5% Source: (gene. exp.) ![]() ![]() ![]() ![]() |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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Sample preparation
Crystal grow | *PLUS Method: other |
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Processing
Software | Name: ![]() |
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NMR software | Name: Discover / Developer: BIOSYM TECHNOLOGIES / Classification: refinement |
NMR ensemble | Conformers submitted total number: 20 |