+
データを開く
-
基本情報
登録情報 | データベース: PDB / ID: 1frt | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
タイトル | CRYSTAL STRUCTURE OF THE COMPLEX OF RAT NEONATAL FC RECEPTOR WITH FC | |||||||||
![]() |
| |||||||||
![]() | COMPLEX (RECEPTOR/IMMUNOGLOBULIN) / COMPLEX (RECEPTOR-IMMUNOGLOBULIN) / COMPLEX (RECEPTOR-IMMUNOGLOBULIN) complex | |||||||||
機能・相同性 | ![]() Endosomal/Vacuolar pathway / DAP12 interactions / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / Antigen Presentation: Folding, assembly and peptide loading of class I MHC / ER-Phagosome pathway / DAP12 signaling / IgG receptor activity / IgG binding / Neutrophil degranulation / humoral immune response ...Endosomal/Vacuolar pathway / DAP12 interactions / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / Antigen Presentation: Folding, assembly and peptide loading of class I MHC / ER-Phagosome pathway / DAP12 signaling / IgG receptor activity / IgG binding / Neutrophil degranulation / humoral immune response / beta-2-microglobulin binding / response to cadmium ion / cellular response to iron ion / cellular response to iron(III) ion / antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent / negative regulation of forebrain neuron differentiation / regulation of erythrocyte differentiation / peptide antigen assembly with MHC class I protein complex / regulation of iron ion transport / response to molecule of bacterial origin / MHC class I peptide loading complex / HFE-transferrin receptor complex / T cell mediated cytotoxicity / antigen processing and presentation of endogenous peptide antigen via MHC class I / positive regulation of T cell cytokine production / MHC class I protein complex / multicellular organismal-level iron ion homeostasis / negative regulation of neurogenesis / positive regulation of receptor-mediated endocytosis / peptide antigen assembly with MHC class II protein complex / MHC class II protein complex / cellular response to nicotine / positive regulation of T cell mediated cytotoxicity / peptide antigen binding / positive regulation of cellular senescence / negative regulation of epithelial cell proliferation / antigen processing and presentation of exogenous peptide antigen via MHC class II / positive regulation of immune response / positive regulation of T cell activation / sensory perception of smell / negative regulation of neuron projection development / MHC class II protein complex binding / late endosome membrane / iron ion transport / T cell differentiation in thymus / protein refolding / protein homotetramerization / intracellular iron ion homeostasis / amyloid fibril formation / learning or memory / endosome membrane / response to xenobiotic stimulus / immune response / external side of plasma membrane / lysosomal membrane / structural molecule activity / protein homodimerization activity / extracellular space / identical protein binding 類似検索 - 分子機能 | |||||||||
生物種 | ![]() ![]() | |||||||||
手法 | ![]() | |||||||||
![]() | Burmeister, W.P. / Bjorkman, P.J. | |||||||||
![]() | ![]() タイトル: Crystal structure of the complex of rat neonatal Fc receptor with Fc. 著者: Burmeister, W.P. / Huber, A.H. / Bjorkman, P.J. #1: ![]() タイトル: Crystal Structure at 2.2 Angstroms Resolution of the Mhc-Related Neonatal Fc Receptor 著者: Burmeister, W.P. / Gastinel, L.N. / Simister, N.E. / Blum, M.L. / Bjorkman, P.J. #2: ![]() タイトル: Investigation of the Interaction between the Class I Mhc-Related Fc Receptor and its Immunoglobulin G Ligand 著者: Raghavan, M. / Chen, M.Y. / Gastinel, L.N. / Bjorkman, P.J. #3: ![]() タイトル: Crystallization and Stoichiometry of Binding of a Complex between a Rat Intestinal Fc Receptor and Fc 著者: Huber, A.H. / Kelly, R.F. / Gastinel, L.N. / Bjorkman, P.J. #4: ![]() タイトル: Crystallographic Refinement and Atomic Models of a Human Fc Fragment and its Complex with Fragment B of Protein a from Staphylococcus Aureus at 2.9-And 2.8-Angstroms Resolution 著者: Deisenhofer, J. | |||||||||
履歴 |
|
-
構造の表示
構造ビューア | 分子: ![]() ![]() |
---|
-
ダウンロードとリンク
-
ダウンロード
PDBx/mmCIF形式 | ![]() | 129 KB | 表示 | ![]() |
---|---|---|---|---|
PDB形式 | ![]() | 101.2 KB | 表示 | ![]() |
PDBx/mmJSON形式 | ![]() | ツリー表示 | ![]() | |
その他 | ![]() |
-検証レポート
アーカイブディレクトリ | ![]() ![]() | HTTPS FTP |
---|
-関連構造データ
-
リンク
-
集合体
登録構造単位 | ![]()
| ||||||||
---|---|---|---|---|---|---|---|---|---|
1 | ![]()
| ||||||||
単位格子 |
| ||||||||
Atom site foot note | 1: CIS PROLINE - PRO A 207 / 2: CIS PROLINE - PRO B 32 / 3: CIS PROLINE - PRO C 374 | ||||||||
詳細 | MTRIX THE INFORMATION PRESENTED ON SYMMETRY RECORDS BELOW DESCRIBE TRANSFORMATIONS TO GENERATE CRYSTALLOGRAPHIC RELATIONSHIPS AS DESCRIBED IN THE STATEMENT THAT FOLLOWS EACH SYMMETRY OPERATOR. APPLIED TO TRANSFORMED TO MTRIX CHAIN RESIDUES CHAIN RESIDUES RMSD S1 C 1 - C 443 ? 1 - ? 443 THIS TRANSFORMATION GENERATES THE SECOND CHAIN OF THE FC MOLECULE. IF THE SAME OPERATION IS ALSO APPLIED TO THE FCRN MOLECULE, THE "STANDING UP" FCRNFC COMPLEX DISCUSSED IN THE ACCOMPANYING PAPER IS GENERATED. S2 A 1 - A 405 ? 1 - ? 405 S2 B 1 - B 99 ? 1 - ? 99 THIS TRANSFORMATION GENERATES THE SECOND SUBUNIT FOR THE "LYING DOWN" FC RECEPTOR DIMER PRESENTED IN THE ACCOMPANYING PAPER. SYMMETRY1 1 1.000000 0.000000 0.000000 0.00000 SYMMETRY2 1 0.000000 -1.000000 0.000000 145.00000 SYMMETRY3 1 0.000000 0.000000 -1.000000 108.25000 SYMMETRY1 2 -1.000000 0.000000 0.000000 250.00000 SYMMETRY2 2 0.000000 -1.000000 0.000000 72.50000 SYMMETRY3 2 0.000000 0.000000 1.000000 0.00000 |
-
要素
-タンパク質 , 3種, 3分子 ABC
#1: タンパク質 | 分子量: 30322.887 Da / 分子数: 1 / 由来タイプ: 組換発現 / 由来: (組換発現) ![]() ![]() 発現宿主: ![]() ![]() 参照: UniProt: P13599 |
---|---|
#2: タンパク質 | 分子量: 11652.282 Da / 分子数: 1 / 由来タイプ: 組換発現 / 由来: (組換発現) ![]() ![]() 発現宿主: ![]() ![]() 参照: UniProt: P07151 |
#3: タンパク質 | 分子量: 23422.539 Da / 分子数: 1 / 由来タイプ: 組換発現 / 由来: (組換発現) ![]() ![]() 発現宿主: ![]() ![]() 参照: GenBank: 243866 |
-糖 , 3種, 3分子 ![](data/chem/img/NAG.gif)
#4: 多糖 | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose |
---|---|
#5: 多糖 | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose- ...beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose |
#6: 糖 | ChemComp-NAG / |
-詳細
配列の詳細 | THERE ARE A NUMBER OF CLOSE CONTACTS BETWEEN ATOMS IN THIS THIS MOLECULE AND IN SYMMETRY-RELATED MOLECULES. |
---|---|
由来についての詳細 | SOURCE 1 MOLECULE_NAME: FC (IGG) RECEPTOR, NEONATAL (FCRN) THE CELL LINE SECRETES A SOLUBLE FCRN ...SOURCE 1 MOLECULE_NAME: FC (IGG) RECEPTOR, NEONATAL (FCRN) THE CELL LINE SECRETES A SOLUBLE FCRN HETERODIME |
-実験情報
-実験
実験 | 手法: ![]() |
---|
-
試料調製
結晶化 | *PLUS pH: 6.4 / 手法: 蒸気拡散法 | ||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
溶液の組成 | *PLUS
|
-データ収集
放射 | 散乱光タイプ: x-ray |
---|---|
放射波長 | 相対比: 1 |
反射 | Num. obs: 8527 / % possible obs: 67 % / Observed criterion σ(I): 0 |
反射 | *PLUS 最高解像度: 4.5 Å / 最低解像度: 25 Å / 冗長度: 3 % / Rmerge(I) obs: 0.125 |
反射 シェル | *PLUS 最高解像度: 4.5 Å / 最低解像度: 4.7 Å / % possible obs: 23 % / Rmerge(I) obs: 0.289 |
-
解析
ソフトウェア |
| ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
精密化 | 解像度: 4.5→20 Å / σ(F): 0 /
| ||||||||||||
原子変位パラメータ | Biso mean: 199 Å2 | ||||||||||||
精密化ステップ | サイクル: LAST / 解像度: 4.5→20 Å
|