Type: peptide linking / Mass: 75.067 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C2H5NO2 Details: GLYCINE WAS MODELED INTO TO A STRONG FO-FC FEATURE DUE TO THE SHAPE AND ENVIRONMENT OF THE FEATURE
Mass: 18.015 Da / Num. of mol.: 107 / Source method: isolated from a natural source / Formula: H2O
Compound details
ETA IS STRUCTURALLY HOMOLOGOUS TO THE CHYMOTRYPSIN-LIKE SERINE PROTEASES. PEPTIDE BOND CLEAVAGE, ...ETA IS STRUCTURALLY HOMOLOGOUS TO THE CHYMOTRYPSIN-LIKE SERINE PROTEASES. PEPTIDE BOND CLEAVAGE, HOWEVER, HAS NOT BEEN DEMONSTRATED. ETA IS MITOGENIC FOR T LYMPHOCYTES AND REPORTED TO BE A SUPERANTIGEN.
Sequence details
ETA NUMBERING BASED ON STRUCTURAL SIMILARITY TO CHYMOTRYPSIN (W.BODE ET AL., 1989, EMBO J. 8,3467-3475).
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Experimental details
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Experiment
Experiment
Method: X-RAY DIFFRACTION / Number of used crystals: 1
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Sample preparation
Crystal
Density Matthews: 2.91 Å3/Da / Density % sol: 57.71 % / Description: REFINEMENT INCLUDED BULK SOLVENT CORRECTION.
Resolution: 2.1→17 Å / σ(F): 0 Details: GLY 300: GLYCINE WAS MODELED INTO TO A STRONG FO-FC FEATURE DUE TO THE SHAPE AND ENVIRONMENT OF THE FEATURE THE SIDE CHAINS OF RESIDUES GLU 1E, GLU1F, AND ARG 221A WERE NOT VISIBLE BEYOND CB. ...Details: GLY 300: GLYCINE WAS MODELED INTO TO A STRONG FO-FC FEATURE DUE TO THE SHAPE AND ENVIRONMENT OF THE FEATURE THE SIDE CHAINS OF RESIDUES GLU 1E, GLU1F, AND ARG 221A WERE NOT VISIBLE BEYOND CB. THEREFORE THE OCCUPANCY OF THESE ATOMS WERE SET TO 0. THE CONFORMATION OF THESE SIDE CHAINS WERE TAKEN FROM ANOTHER CRYSTAL FORM OF ETA (MONOCLINIC FORM). GLY 300: GLYCINE WAS MODELED INTO TO A STRONG FO-FC FEATURE DUE TO THE SHAPE AND ENVIRONMENT OF THE FEATURE.
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