Entry | Database: PDB / ID: 6ns7 |
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Title | Crystal structure of murine caspase-11 |
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Components | Caspase-11 |
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Keywords | IMMUNE SYSTEM / inflammation / enzyme / caspase / pyroptosis |
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Function / homology | Function and homology information
caspase-11 / non-canonical inflammasome complex / positive regulation of interleukin-18-mediated signaling pathway / Pyroptosis / non-canonical inflammasome complex assembly / detection of lipopolysaccharide / NLRP1 inflammasome complex / NOD1/2 Signaling Pathway / positive regulation of macrophage cytokine production / positive regulation of NLRP3 inflammasome complex assembly ...caspase-11 / non-canonical inflammasome complex / positive regulation of interleukin-18-mediated signaling pathway / Pyroptosis / non-canonical inflammasome complex assembly / detection of lipopolysaccharide / NLRP1 inflammasome complex / NOD1/2 Signaling Pathway / positive regulation of macrophage cytokine production / positive regulation of NLRP3 inflammasome complex assembly / pyroptotic inflammatory response / protein autoprocessing / protein maturation / ectopic germ cell programmed cell death / positive regulation of interleukin-1 beta production / actin filament organization / lipopolysaccharide binding / positive regulation of inflammatory response / positive regulation of neuron apoptotic process / regulation of inflammatory response / scaffold protein binding / defense response to Gram-positive bacterium / defense response to bacterium / inflammatory response / cysteine-type endopeptidase activity / innate immune response / neuronal cell body / lipid binding / endoplasmic reticulum membrane / protein-containing complex / mitochondrion / extracellular region / cytosol / cytoplasmSimilarity search - Function Caspase recruitment domain / CARD domain / CARD caspase recruitment domain profile. / Caspase recruitment domain / Peptidase family C14A, His active site / Caspase family histidine active site. / Peptidase C14, caspase non-catalytic subunit p10 / Peptidase family C14A, cysteine active site / Caspase family cysteine active site. / Caspase family p10 domain profile. ...Caspase recruitment domain / CARD domain / CARD caspase recruitment domain profile. / Caspase recruitment domain / Peptidase family C14A, His active site / Caspase family histidine active site. / Peptidase C14, caspase non-catalytic subunit p10 / Peptidase family C14A, cysteine active site / Caspase family cysteine active site. / Caspase family p10 domain profile. / Peptidase C14A, caspase catalytic domain / Caspase, interleukin-1 beta converting enzyme (ICE) homologues / Peptidase C14, p20 domain / Caspase family p20 domain profile. / : / Caspase domain / Caspase-like domain superfamily / Death-like domain superfamilySimilarity search - Domain/homology |
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Biological species | ![](img/tx_mammal.gif) Mus musculus (house mouse) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.4 Å |
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Authors | Yang, J. / Liu, Z. / Xiao, T.S. |
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Funding support | United States, 1items Organization | Grant number | Country |
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National Institutes of Health/National Human Genome Research Institute (NIH/NHGRI) | GM127609 | United States |
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Citation | Journal: To Be Published Title: Crystal structure of murine caspase-11 Authors: Yang, J. / Liu, Z. / Xiao, T.S. |
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History | Deposition | Jan 24, 2019 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Jul 29, 2020 | Provider: repository / Type: Initial release |
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Revision 1.1 | Oct 11, 2023 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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