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- PDB-1epj: THREE-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE STRUCTURES OF MOUSE ... -
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Basic information
Entry | Database: PDB / ID: 1epj | ||||||
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Title | THREE-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE STRUCTURES OF MOUSE EPIDERMAL GROWTH FACTOR IN ACIDIC AND PHYSIOLOGICAL PH SOLUTIONS | ||||||
![]() | EPIDERMAL GROWTH FACTOR | ||||||
![]() | GROWTH FACTOR | ||||||
Function / homology | ![]() Signaling by ERBB4 / EGFR interacts with phospholipase C-gamma / ERBB2 Activates PTK6 Signaling / Signaling by EGFR / PI3K events in ERBB2 signaling / SHC1 events in ERBB2 signaling / GRB2 events in EGFR signaling / SHC1 events in EGFR signaling / Signaling by ERBB2 / GAB1 signalosome ...Signaling by ERBB4 / EGFR interacts with phospholipase C-gamma / ERBB2 Activates PTK6 Signaling / Signaling by EGFR / PI3K events in ERBB2 signaling / SHC1 events in ERBB2 signaling / GRB2 events in EGFR signaling / SHC1 events in EGFR signaling / Signaling by ERBB2 / GAB1 signalosome / ERBB2 Regulates Cell Motility / NOTCH3 Activation and Transmission of Signal to the Nucleus / Downregulation of ERBB2 signaling / EGFR downregulation / negative regulation of secretion / regulation of protein transport / positive regulation of hyaluronan biosynthetic process / negative regulation of cholesterol efflux / Extra-nuclear estrogen signaling / RAF/MAP kinase cascade / positive regulation of cerebellar granule cell precursor proliferation / cerebellar granule cell precursor proliferation / PIP3 activates AKT signaling / positive regulation of epithelial tube formation / Wnt receptor activity / Platelet degranulation / regulation of calcium ion import / positive regulation of protein localization to early endosome / Cargo recognition for clathrin-mediated endocytosis / regulation of protein localization to cell surface / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / Clathrin-mediated endocytosis / Wnt-protein binding / positive regulation of ubiquitin-dependent protein catabolic process / regulation of receptor signaling pathway via JAK-STAT / ERBB2-EGFR signaling pathway / epidermal growth factor receptor binding / positive regulation of DNA biosynthetic process / branching morphogenesis of an epithelial tube / transmembrane receptor protein tyrosine kinase activator activity / positive regulation of receptor internalization / mammary gland alveolus development / canonical Wnt signaling pathway / positive regulation of DNA binding / regulation of peptidyl-tyrosine phosphorylation / positive regulation of endothelial cell proliferation / ERK1 and ERK2 cascade / positive regulation of endothelial cell migration / positive regulation of mitotic nuclear division / guanyl-nucleotide exchange factor activity / positive regulation of peptidyl-threonine phosphorylation / epithelial cell proliferation / positive regulation of epithelial cell proliferation / growth factor activity / epidermal growth factor receptor signaling pathway / positive regulation of peptidyl-tyrosine phosphorylation / positive regulation of fibroblast proliferation / positive regulation of canonical Wnt signaling pathway / angiogenesis / cell population proliferation / positive regulation of MAPK cascade / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / receptor ligand activity / positive regulation of ERK1 and ERK2 cascade / calcium ion binding / positive regulation of cell population proliferation / positive regulation of gene expression / positive regulation of DNA-templated transcription / extracellular space / extracellular exosome / extracellular region / plasma membrane Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | SOLUTION NMR | ||||||
![]() | Kohda, D. / Inagaki, F. | ||||||
![]() | ![]() Title: Three-dimensional nuclear magnetic resonance structures of mouse epidermal growth factor in acidic and physiological pH solutions. Authors: Kohda, D. / Inagaki, F. #1: ![]() Title: Structure of Epidermal Growth Factor Bound to Perdeuterated Dodecylphosphocholine Micelles Determined by Two-Dimensional NMR and Simulated Annealing Calculations Authors: Kohda, D. / Inagaki, F. #2: ![]() Title: Characterization of Ph Titration Shifts for All the Nonlabile Proton Resonances in a Protein by Two-Dimensional NMR: The Case of Mouse Epidermal Growth Factor Authors: Kohda, D. / Sawada, T. / Inagaki, F. #3: ![]() Title: Tertiary Structure of Mouse Epidermal Growth Factor Determined by Two-Dimensional 1H NMR Authors: Kohda, D. / Go, N. / Hayashi, K. / Inagaki, F. #4: ![]() Title: A Comparative 1H NMR Study of Mouse Alpha(1-53) and Beta(2-53) Epidermal Growth Factors Authors: Kohda, D. / Kodama, C. / Kase, R. / Nomoto, H. / Hayashi, K. / Inagaki, F. #5: ![]() Title: Complete Sequence-Specific 1H Nuclear Magnetic Resonance Assignments for Mouse Epidermal Growth Factor Authors: Kohda, D. / Inagaki, F. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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PDBx/mmCIF format | ![]() | 94.5 KB | Display | ![]() |
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PDB format | ![]() | 79.7 KB | Display | ![]() |
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-Validation report
Summary document | ![]() | 355.2 KB | Display | ![]() |
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Full document | ![]() | 397.7 KB | Display | |
Data in XML | ![]() | 9.6 KB | Display | |
Data in CIF | ![]() | 13.7 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
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Links
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Assembly
Deposited unit | ![]()
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NMR ensembles |
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Components
#1: Protein | Mass: 6050.717 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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Sample preparation
Crystal grow | *PLUS Method: other / Details: NMR |
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Processing
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NMR software | Name: ![]() | ||||||||
NMR ensemble | Conformers submitted total number: 5 |