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- PDB-1egf: SOLUTION STRUCTURE OF MURINE EPIDERMAL GROWTH FACTOR DETERMINED B... -
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Basic information
Entry | Database: PDB / ID: 1egf | ||||||
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Title | SOLUTION STRUCTURE OF MURINE EPIDERMAL GROWTH FACTOR DETERMINED BY NMR SPECTROSCOPY AND REFINED BY ENERGY MINIMIZATION WITH RESTRAINTS | ||||||
![]() | EPIDERMAL GROWTH FACTOR | ||||||
![]() | GROWTH FACTOR | ||||||
Function / homology | ![]() Signaling by ERBB4 / EGFR interacts with phospholipase C-gamma / ERBB2 Activates PTK6 Signaling / Signaling by EGFR / PI3K events in ERBB2 signaling / SHC1 events in ERBB2 signaling / GRB2 events in EGFR signaling / SHC1 events in EGFR signaling / Signaling by ERBB2 / GAB1 signalosome ...Signaling by ERBB4 / EGFR interacts with phospholipase C-gamma / ERBB2 Activates PTK6 Signaling / Signaling by EGFR / PI3K events in ERBB2 signaling / SHC1 events in ERBB2 signaling / GRB2 events in EGFR signaling / SHC1 events in EGFR signaling / Signaling by ERBB2 / GAB1 signalosome / ERBB2 Regulates Cell Motility / NOTCH3 Activation and Transmission of Signal to the Nucleus / Downregulation of ERBB2 signaling / EGFR downregulation / negative regulation of secretion / regulation of protein transport / positive regulation of hyaluronan biosynthetic process / negative regulation of cholesterol efflux / Extra-nuclear estrogen signaling / RAF/MAP kinase cascade / positive regulation of cerebellar granule cell precursor proliferation / cerebellar granule cell precursor proliferation / PIP3 activates AKT signaling / positive regulation of epithelial tube formation / Wnt receptor activity / Platelet degranulation / regulation of calcium ion import / positive regulation of protein localization to early endosome / Cargo recognition for clathrin-mediated endocytosis / regulation of protein localization to cell surface / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / Clathrin-mediated endocytosis / Wnt-protein binding / positive regulation of ubiquitin-dependent protein catabolic process / regulation of receptor signaling pathway via JAK-STAT / ERBB2-EGFR signaling pathway / epidermal growth factor receptor binding / positive regulation of DNA biosynthetic process / branching morphogenesis of an epithelial tube / transmembrane receptor protein tyrosine kinase activator activity / positive regulation of receptor internalization / mammary gland alveolus development / canonical Wnt signaling pathway / positive regulation of DNA binding / regulation of peptidyl-tyrosine phosphorylation / positive regulation of endothelial cell proliferation / ERK1 and ERK2 cascade / positive regulation of endothelial cell migration / positive regulation of mitotic nuclear division / guanyl-nucleotide exchange factor activity / positive regulation of peptidyl-threonine phosphorylation / epithelial cell proliferation / positive regulation of epithelial cell proliferation / growth factor activity / epidermal growth factor receptor signaling pathway / positive regulation of peptidyl-tyrosine phosphorylation / positive regulation of fibroblast proliferation / positive regulation of canonical Wnt signaling pathway / angiogenesis / cell population proliferation / positive regulation of MAPK cascade / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / receptor ligand activity / positive regulation of ERK1 and ERK2 cascade / calcium ion binding / positive regulation of cell population proliferation / positive regulation of gene expression / positive regulation of DNA-templated transcription / extracellular space / extracellular exosome / extracellular region / plasma membrane Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | SOLUTION NMR | ||||||
![]() | Montelione, G.T. / Wuthrich, K. / Scheraga, H.A. | ||||||
![]() | ![]() Title: Solution structure of murine epidermal growth factor determined by NMR spectroscopy and refined by energy minimization with restraints. Authors: Montelione, G.T. / Wuthrich, K. / Burgess, A.W. / Nice, E.C. / Wagner, G. / Gibson, K.D. / Scheraga, H.A. #1: ![]() Title: Sequence-Specific 1H NMR Assignments and Identification of Slowly Exchanging Amide Protons in Murine Epidermal Growth Factor Authors: Montelione, G.T. / Wuthrich, K. / Scheraga, H.A. #2: ![]() Title: Solution Structure of Murine Epidermal Growth Factor: Determination of the Polypeptide Backbone Chain-Fold by Nuclear Magnetic Resonance and Distance Geometry Authors: Montelione, G.T. / Wuthrich, K. / Nice, E.C. / Burgess, A.W. / Scheraga, H.A. #3: ![]() Title: Identification of Two Anti-Parallel Beta-Sheet Conformations in the Solution Structure of Murine Epidermal Growth Factor by Proton Magnetic Resonance Authors: Montelione, G.T. / Wuthrich, K. / Nice, E.C. / Burgess, A.W. / Scheraga, H.A. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 138 KB | Display | ![]() |
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PDB format | ![]() | 115.8 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
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-Validation report
Summary document | ![]() | 338.2 KB | Display | ![]() |
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Full document | ![]() | 470.8 KB | Display | |
Data in XML | ![]() | 25 KB | Display | |
Data in CIF | ![]() | 37 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
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Links
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Assembly
Deposited unit | ![]()
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1 |
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NMR ensembles |
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Components
#1: Protein | Mass: 6050.717 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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Sample preparation
Crystal grow | *PLUS Method: other / Details: NMR |
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Processing
NMR software | Name: DISMAN / Developer: BRAUN,GO / Classification: refinement |
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NMR ensemble | Conformers submitted total number: 16 |