+Open data
-Basic information
Entry | Database: PDB / ID: 1edn | ||||||
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Title | HUMAN ENDOTHELIN-1 | ||||||
Components | ENDOTHELIN-1 | ||||||
Keywords | VASOCONSTRICTOR / SIGNAL POLYPEPTIDE G-PROTEIN COUPLED-RECEPTOR LIGAND | ||||||
Function / homology | Function and homology information positive regulation of prostaglandin-endoperoxide synthase activity / endothelin A receptor binding / protein kinase C deactivation / cellular response to human chorionic gonadotropin stimulus / meiotic cell cycle process involved in oocyte maturation / phospholipase D-activating G protein-coupled receptor signaling pathway / rhythmic excitation / endothelin B receptor binding / peptide hormone secretion / neural crest cell fate commitment ...positive regulation of prostaglandin-endoperoxide synthase activity / endothelin A receptor binding / protein kinase C deactivation / cellular response to human chorionic gonadotropin stimulus / meiotic cell cycle process involved in oocyte maturation / phospholipase D-activating G protein-coupled receptor signaling pathway / rhythmic excitation / endothelin B receptor binding / peptide hormone secretion / neural crest cell fate commitment / sympathetic neuron axon guidance / positive regulation of artery morphogenesis / glomerular endothelium development / vein smooth muscle contraction / body fluid secretion / noradrenergic neuron differentiation / response to prostaglandin F / positive regulation of sarcomere organization / leukocyte activation / positive regulation of renal sodium excretion / histamine secretion / positive regulation of chemokine-mediated signaling pathway / maternal process involved in parturition / rough endoplasmic reticulum lumen / pharyngeal arch artery morphogenesis / regulation of glucose transmembrane transport / positive regulation of odontogenesis / endothelin receptor signaling pathway involved in heart process / epithelial fluid transport / cardiac neural crest cell migration involved in outflow tract morphogenesis / negative regulation of hormone secretion / response to leptin / endothelin receptor signaling pathway / Weibel-Palade body / podocyte differentiation / response to ozone / renal sodium ion absorption / glomerular filtration / positive regulation of cell growth involved in cardiac muscle cell development / artery smooth muscle contraction / axonogenesis involved in innervation / positive regulation of cation channel activity / cellular response to follicle-stimulating hormone stimulus / positive regulation of prostaglandin secretion / cellular response to luteinizing hormone stimulus / negative regulation of nitric-oxide synthase biosynthetic process / cellular response to mineralocorticoid stimulus / basal part of cell / respiratory gaseous exchange by respiratory system / positive regulation of urine volume / positive regulation of smooth muscle contraction / response to salt / regulation of pH / semaphorin-plexin signaling pathway involved in axon guidance / positive regulation of hormone secretion / regulation of systemic arterial blood pressure by endothelin / vasoconstriction / : / embryonic heart tube development / negative regulation of blood coagulation / dorsal/ventral pattern formation / axon extension / superoxide anion generation / positive regulation of neutrophil chemotaxis / positive regulation of signaling receptor activity / cartilage development / middle ear morphogenesis / cellular response to glucocorticoid stimulus / prostaglandin biosynthetic process / negative regulation of protein metabolic process / nitric oxide transport / cellular response to fatty acid / branching involved in blood vessel morphogenesis / positive regulation of heart rate / : / response to testosterone / positive regulation of cardiac muscle hypertrophy / response to dexamethasone / negative regulation of smooth muscle cell apoptotic process / membrane depolarization / thyroid gland development / positive regulation of cell size / regulation of vasoconstriction / response to amino acid / canonical Wnt signaling pathway / cellular response to interleukin-1 / positive regulation of calcium-mediated signaling / positive regulation of JUN kinase activity / transport vesicle / positive regulation of vascular associated smooth muscle cell proliferation / cellular response to transforming growth factor beta stimulus / protein kinase A signaling / response to amphetamine / cellular response to calcium ion / response to muscle stretch / ERK1 and ERK2 cascade / adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway / positive regulation of endothelial cell migration / positive regulation of mitotic nuclear division / mitochondrion organization Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / Resolution: 2.18 Å | ||||||
Authors | Wallace, B.A. / Janes, R.W. | ||||||
Citation | Journal: Nat.Struct.Biol. / Year: 1994 Title: The crystal structure of human endothelin. Authors: Janes, R.W. / Peapus, D.H. / Wallace, B.A. #1: Journal: To be Published Title: Comparison of the Structure of the Endothelin Receptor Agonist Bq123 with the Crystal Structure of the C-Terminal Tail of Endothelin Authors: Peishoff, C.E. / Janes, R.W. / Wallace, B.A. #2: Journal: Protein Sci. / Year: 1995 Title: A Comparison of X-Ray and NMR Structures for Human Endothelin-1 Authors: Wallace, B.A. / Janes, R.W. / Bassolino, D. / Krystek Junior, S. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 1edn.cif.gz | 10.2 KB | Display | PDBx/mmCIF format |
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PDB format | pdb1edn.ent.gz | 8.1 KB | Display | PDB format |
PDBx/mmJSON format | 1edn.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 1edn_validation.pdf.gz | 361.2 KB | Display | wwPDB validaton report |
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Full document | 1edn_full_validation.pdf.gz | 362.3 KB | Display | |
Data in XML | 1edn_validation.xml.gz | 2.1 KB | Display | |
Data in CIF | 1edn_validation.cif.gz | 2.4 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/ed/1edn ftp://data.pdbj.org/pub/pdb/validation_reports/ed/1edn | HTTPS FTP |
-Related structure data
Similar structure data |
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-Links
-Assembly
Deposited unit |
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1 |
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Unit cell |
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-Components
#1: Protein/peptide | Mass: 2497.951 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / References: UniProt: P05305 |
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-Experimental details
-Experiment
Experiment | Method: X-RAY DIFFRACTION |
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-Sample preparation
Crystal | Density Matthews: 1.9 Å3/Da / Density % sol: 35.43 % |
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Crystal grow | *PLUS Method: x-ray capillaries |
Components of the solutions | *PLUS Conc.: 9 mg/ml |
-Data collection
Diffraction source | Wavelength: 1.54 |
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Detector | Type: MARRESEARCH / Detector: IMAGE PLATE / Date: Nov 12, 1992 |
Radiation | Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength: 1.54 Å / Relative weight: 1 |
Reflection | Resolution: 2.18→8 Å / Num. obs: 1876 / % possible obs: 99 % / Observed criterion σ(I): 0 / Redundancy: 3 % / Rmerge(I) obs: 0.107 |
Reflection | *PLUS Num. measured all: 8907 / Rmerge(I) obs: 0.107 |
-Processing
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Refinement | Resolution: 2.18→8 Å / σ(F): 3 /
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Refinement step | Cycle: LAST / Resolution: 2.18→8 Å
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Refine LS restraints |
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