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COMPLEMENTCONTROLPROTEINC3 / SP35 / 28 KDA PROTEIN / SECRETORY PROTEIN 35 / PROTEIN C3 / VCP
Mass: 12783.905 Da / Num. of mol.: 1 / Fragment: MODULES 2 AND 3 RESIDUES 84-203 Source method: isolated from a genetically manipulated source Source: (gene. exp.) VACCINIA VIRUS / Strain: COPENHAGEN / Gene: C21L / Plasmid: PPICZALPHAA WITHOUT HISTIDINE DEFICIENCY / Production host: PICHIA PASTORIS (fungus) / Strain (production host): KM71 / References: UniProt: P68639
Compound details
FUNCTION: SERVES TO PROTECT THE VIRUS AGAINST COMPLEMENT ATTACK BY INHIBITING BOTH CLASSICAL AND ...FUNCTION: SERVES TO PROTECT THE VIRUS AGAINST COMPLEMENT ATTACK BY INHIBITING BOTH CLASSICAL AND ALTERNATIVE PATHWAYS OF COMPLEMENT ACTIVATION. BINDS C3B AND C4B. SIMILARITY: BELONGS TO THE SUPERFAMILY OF THE REGULATORS OF COMPLEMENT ACTIVATION (RCA). SIMILARITY: CONTAINS 4 SUSHI (SCR) REPEATS.
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Experimental details
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Experiment
Experiment
Method: SOLUTION NMR
NMR experiment
Conditions-ID
Experiment-ID
Solution-ID
Type
1
1
1
2D NOESY
1
2
1
COSY
1
3
1
TOCSY
1
4
1
3D HSQCNOESY
1
5
1
TOCSY
NMR details
Text: 15N-LABELLED VCP MODULES 2 AND 3 WAS USED TO OBTAIN HSQC NOESY AND TOCSY EXPERIMENTS TO ASSIGN THE BACKBONE ATOMS. 2D EXPERIMENTS WERE THEN USED IN CONJUNCTION WITH THE 3D TECHNIQUES TO ASSIGN ...Text: 15N-LABELLED VCP MODULES 2 AND 3 WAS USED TO OBTAIN HSQC NOESY AND TOCSY EXPERIMENTS TO ASSIGN THE BACKBONE ATOMS. 2D EXPERIMENTS WERE THEN USED IN CONJUNCTION WITH THE 3D TECHNIQUES TO ASSIGN THE SIDE CHAIN ATOMS AND THE STRUCTURE WAS CALCULATED USING UNAMBIGUOUS AND AMBIGUOUS RESTRAINTS
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