- PDB-1e51: Crystal structure of native human erythrocyte 5-aminolaevulinic a... -
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基本情報
登録情報
データベース: PDB / ID: 1.0E+51
タイトル
Crystal structure of native human erythrocyte 5-aminolaevulinic acid dehydratase
要素
DELTA-AMINOLEVULINIC ACID DEHYDRATASE
キーワード
LYASE / DEHYDRATASE / TETRAPYRROLE BIOSYNTHESIS / TIM BARREL / PORPHOBILINOGEN SYNTHASE / LEAD POISONING
機能・相同性
機能・相同性情報
proteasome core complex binding / response to vitamin B1 / response to platinum ion / porphobilinogen synthase / porphobilinogen synthase activity / heme B biosynthetic process / heme O biosynthetic process / heme A biosynthetic process / negative regulation of proteasomal protein catabolic process / response to aluminum ion ...proteasome core complex binding / response to vitamin B1 / response to platinum ion / porphobilinogen synthase / porphobilinogen synthase activity / heme B biosynthetic process / heme O biosynthetic process / heme A biosynthetic process / negative regulation of proteasomal protein catabolic process / response to aluminum ion / cellular response to lead ion / response to mercury ion / response to selenium ion / protoporphyrinogen IX biosynthetic process / response to fatty acid / response to cobalt ion / response to methylmercury / response to arsenic-containing substance / response to iron ion / response to herbicide / Heme biosynthesis / heme biosynthetic process / response to ionizing radiation / response to zinc ion / response to vitamin E / response to amino acid / catalytic activity / cellular response to interleukin-4 / response to cadmium ion / response to glucocorticoid / response to activity / protein homooligomerization / secretory granule lumen / response to ethanol / response to oxidative stress / ficolin-1-rich granule lumen / response to lipopolysaccharide / response to hypoxia / response to xenobiotic stimulus / Neutrophil degranulation / zinc ion binding / extracellular exosome / extracellular region / identical protein binding / nucleus / cytosol 類似検索 - 分子機能
Delta-aminolevulinic acid dehydratase / Delta-aminolevulinic acid dehydratase, active site / Delta-aminolevulinic acid dehydratase / Delta-aminolevulinic acid dehydratase active site. / Delta-aminolevulinic acid dehydratase / Aldolase class I / Aldolase-type TIM barrel / TIM Barrel / Alpha-Beta Barrel / Alpha Beta 類似検索 - ドメイン・相同性
分子量: 36338.852 Da / 分子数: 2 / 由来タイプ: 天然 / 詳細: PORPHOBILINOGEN IN ACTIVE SITE OF MONOMER A / 由来: (天然) HOMO SAPIENS (ヒト) / Cell: ERYTHROCYTES / 参照: UniProt: P13716, porphobilinogen synthase
PORPHOBILINOGEN PRODUCT MOLECULE BOUND AT MONOMER A ACTIVE SITE. SECOND STEP IN PORPHYRIN AND HEME ...PORPHOBILINOGEN PRODUCT MOLECULE BOUND AT MONOMER A ACTIVE SITE. SECOND STEP IN PORPHYRIN AND HEME BIOSYNTHESIS DISEASE: DEFECTS IN ALAD ARE THE CAUSE OF ACUTE HEPATIC PORPHYRIA CATALYTIC ACTIVITY: 2 5-AMINOLEVULINATE = PORPHOBILINOGEN + H(2)O COFACTOR: ZINC POLYMORPHISM: THERE ARE TWO COMMON ALLELES OF ALAD. INDIVIDUALS HETEROZYGOUS OR HOMOZYGOUS FOR THE 2ND ALLELE HAVE SIGNIFICANTLY HIGHER BLOOD LEAD LEVELS THAN DO 1ST ALLELE HOMOZYGOTES WHEN EXPOSED TO ENVIRONMENTAL LEAD.
解像度: 2.83→44.38 Å / Rfactor Rfree error: 0.009 / Isotropic thermal model: RESTRAINED / 交差検証法: THROUGHOUT / σ(F): 0 詳細: BREAK IN CHAIN A 137-138 DUE TO DISORDER. BREAKS IN CHAIN B 89-93, 127-142 AND 213-220 DUE TO DISORDER.