+Open data
-Basic information
Entry | Database: PDB / ID: 1e4q | ||||||
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Title | Solution structure of the human defensin hBD-2 | ||||||
Components | BETA-DEFENSIN 2 | ||||||
Keywords | DEFENSIN / HUMAN | ||||||
Function / homology | Function and homology information CCR6 chemokine receptor binding / Beta defensins / Defensins / antifungal innate immune response / chemoattractant activity / defense response to fungus / phosphatidylinositol-4,5-bisphosphate binding / cell chemotaxis / Golgi lumen / chemotaxis ...CCR6 chemokine receptor binding / Beta defensins / Defensins / antifungal innate immune response / chemoattractant activity / defense response to fungus / phosphatidylinositol-4,5-bisphosphate binding / cell chemotaxis / Golgi lumen / chemotaxis / antimicrobial humoral immune response mediated by antimicrobial peptide / killing of cells of another organism / defense response to Gram-negative bacterium / defense response to Gram-positive bacterium / defense response to bacterium / immune response / G protein-coupled receptor signaling pathway / extracellular space / extracellular region Similarity search - Function | ||||||
Biological species | HOMO SAPIENS (human) | ||||||
Method | SOLUTION NMR / simulated annealing | ||||||
Authors | Bauer, F. / Schweimer, K. / Kluver, E. / Adermann, K. / Forssmann, W.G. / Roesch, P. / Sticht, H. | ||||||
Citation | Journal: Protein Sci. / Year: 2001 Title: Structure Determination of Human and Murine Beta-Defensins Reveals Structural Conservation in the Absence of Significant Sequence Similarity Authors: Bauer, F. / Schweimer, K. / Kluver, E. / Conejo-Garcia, J. / Forssmann, W.G. / Roesch, P. / Adermann, K. / Sticht, H. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 1e4q.cif.gz | 222.1 KB | Display | PDBx/mmCIF format |
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PDB format | pdb1e4q.ent.gz | 186.7 KB | Display | PDB format |
PDBx/mmJSON format | 1e4q.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/e4/1e4q ftp://data.pdbj.org/pub/pdb/validation_reports/e4/1e4q | HTTPS FTP |
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-Related structure data
-Links
-Assembly
Deposited unit |
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1 |
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NMR ensembles |
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-Components
#1: Protein/peptide | Mass: 3999.922 Da / Num. of mol.: 1 / Fragment: RESIDUES 28-64 OF THE BETA-DEFENSIN 2 PRECURSOR / Source method: obtained synthetically / Source: (synth.) HOMO SAPIENS (human) / References: UniProt: O15263 |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR | ||||||||||||||||
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NMR experiment |
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-Sample preparation
Sample conditions | pH: 4.0 / Pressure: 1 atm / Temperature: 298 K |
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Crystal grow | *PLUS Method: other / Details: NMR |
-NMR measurement
NMR spectrometer |
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-Processing
NMR software |
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Refinement | Method: simulated annealing / Software ordinal: 1 Details: REFINEMENT DETAILS CAN BE FOUND IN THE JRNL CITATION ABOVE. | ||||||||||||||||
NMR ensemble | Conformer selection criteria: LOWEST ENERGY, LEAST RESTRAINT VIOLATION Conformers calculated total number: 60 / Conformers submitted total number: 20 |