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- PDB-1djl: THE CRYSTAL STRUCTURE OF HUMAN TRANSHYDROGENASE DOMAIN III WITH B... -
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Open data
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Basic information
Entry | Database: PDB / ID: 1djl | ||||||
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Title | THE CRYSTAL STRUCTURE OF HUMAN TRANSHYDROGENASE DOMAIN III WITH BOUND NADP | ||||||
![]() | TRANSHYDROGENASE DIII | ||||||
![]() | OXIDOREDUCTASE / ROSSMANN FOLD DINUCLEOTIDE BINDING FOLD REVERSE BINDING OF NADP | ||||||
Function / homology | ![]() response to vitamin / NAD(P)+ transhydrogenase (Si-specific) activity / : / proton-translocating NAD(P)+ transhydrogenase / Citric acid cycle (TCA cycle) / NADPH regeneration / intracellular oxygen homeostasis / positive regulation of hydrogen peroxide catabolic process / : / positive regulation of mitochondrial membrane potential ...response to vitamin / NAD(P)+ transhydrogenase (Si-specific) activity / : / proton-translocating NAD(P)+ transhydrogenase / Citric acid cycle (TCA cycle) / NADPH regeneration / intracellular oxygen homeostasis / positive regulation of hydrogen peroxide catabolic process / : / positive regulation of mitochondrial membrane potential / cellular oxidant detoxification / tricarboxylic acid cycle / proton transmembrane transport / reactive oxygen species metabolic process / cell redox homeostasis / negative regulation of protein phosphorylation / NAD binding / NADP binding / mitochondrial inner membrane / negative regulation of apoptotic process / mitochondrion / membrane Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() | ||||||
![]() | White, S.A. / Peak, S.J. / Cotton, N.P. / Jackson, J.B. | ||||||
![]() | ![]() Title: The high-resolution structure of the NADP(H)-binding component (dIII) of proton-translocating transhydrogenase from human heart mitochondria. Authors: White, S.A. / Peake, S.J. / McSweeney, S. / Leonard, G. / Cotton, N.P. / Jackson, J.B. #1: ![]() Title: Structure and Mechanism of Proton-Translocating Transhydrogenase: A Mini-Review Authors: Jackson, J.B. / Peak, S.J. / White, S.A. #2: ![]() Title: The NADPH-Binding Component (dIII) of Human-Heart Transhydrogenase: Crystallisation and Preliminary Crystallographic Analysis Authors: Peak, S.J. / Jackson, J.B. / White, S.A. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 85.3 KB | Display | ![]() |
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PDB format | ![]() | 65.1 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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Unit cell |
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Components
#1: Protein | Mass: 22281.652 Da / Num. of mol.: 2 / Fragment: RESIDUES 837-1086 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() #2: Chemical | #3: Chemical | #4: Chemical | #5: Water | ChemComp-HOH / | |
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-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 2.37 Å3/Da / Density % sol: 48.18 % |
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Crystal grow | Temperature: 291 K / Method: vapor diffusion, hanging drop / pH: 7 Details: AMMONIUM SULPHATE, MOPS, DIOXANE, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 291K |
Crystal grow | *PLUS Method: vapor diffusion, hanging dropDetails: SJ Peake, JB Jackeson and SA White, unpublished data |
-Data collection
Diffraction | Mean temperature: 100 K |
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Diffraction source | Source: ![]() ![]() ![]() |
Detector | Type: ADSC QUANTUM 4 / Detector: CCD |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Relative weight: 1 |
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Processing
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Refinement | Highest resolution: 2 Å /
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Refinement step | Cycle: LAST / Highest resolution: 2 Å
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Software | *PLUS Name: CNS / Classification: refinement | |||||||||||||||
Refine LS restraints | *PLUS
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