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- PDB-1dis: DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEX WITH BRODIMOPRIM-4,... -
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Open data
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Basic information
Entry | Database: PDB / ID: 1dis | ||||||
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Title | DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEX WITH BRODIMOPRIM-4,6-DICARBOXYLATE | ||||||
![]() | DIHYDROFOLATE REDUCTASE | ||||||
![]() | OXIDOREDUCTASE / INHIBITOR-ENZYME COMPLEX / OXIDO-REDUCTASE | ||||||
Function / homology | ![]() response to methotrexate / dihydrofolate metabolic process / glycine biosynthetic process / dihydrofolate reductase / dihydrofolate reductase activity / folic acid metabolic process / tetrahydrofolate biosynthetic process / one-carbon metabolic process / NADP binding / response to antibiotic / cytosol Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | SOLUTION NMR | ||||||
![]() | Morgan, W.D. / Birdsall, B. / Polshakov, V.I. / Sali, D. / Kompis, I. / Feeney, J. | ||||||
![]() | ![]() Title: Solution structure of a brodimoprim analogue in its complex with Lactobacillus casei dihydrofolate reductase. Authors: Morgan, W.D. / Birdsall, B. / Polshakov, V.I. / Sali, D. / Kompis, I. / Feeney, J. #1: ![]() Title: Solution Structure of Bound Trimethoprim in its Complex with Lactobacillus Casei Dihydrofolate Reductase Authors: Martorell, G. / Gradwell, M.J. / Birdsall, B. / Bauer, C.J. / Frenkiel, T.A. / Cheung, H.T.A. / Polshakov, V.I. / Kuyper, L. / Feeney, J. #2: ![]() Title: A 1H NMR Study of the Interactions and Conformations of Rationally Designed Brodimoprim Analogues in Complexes with Lactobacillus Casei Dihydrofolate Reductase Authors: Birdsall, B. / Feeney, J. / Pascual, C. / Roberts, G.C.K. / Kompis, I. / Then, R.L. / Mueller, K. / Kroehn, A. #3: ![]() Title: Crystal Structures of Escherichia Coli and Lactobacillus Casei Dihydrofolate Reductase Refined at 1.7 Angstroms Resolution. I. General Features and Binding of Methotrexate Authors: Bolin, J.T. / Filman, D.J. / Matthews, D.A. / Hamlin, R.C. / Kraut, J. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 64.2 KB | Display | ![]() |
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PDB format | ![]() | 47 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 381.7 KB | Display | ![]() |
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Full document | ![]() | 381.6 KB | Display | |
Data in XML | ![]() | 5.5 KB | Display | |
Data in CIF | ![]() | 7.1 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
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Links
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Assembly
Deposited unit | ![]()
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1 |
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Atom site foot note | 1: CIS PROLINE - PRO 53 2: GLY 98 - GLY 99 OMEGA = 7.98 PEPTIDE BOND DEVIATES SIGNIFICANTLY FROM TRANS CONFORMATION | |||||||||
NMR ensembles |
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Components
#1: Protein | Mass: 18331.594 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() |
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#2: Chemical | ChemComp-BDM / |
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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Sample preparation
Crystal grow | *PLUS Method: other |
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Processing
NMR software | Name: Discover / Classification: refinement |
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NMR ensemble | Conformers submitted total number: 1 |