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- PDB-1ddf: FAS DEATH DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE -

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ID or keywords:

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Basic information

Entry
Database: PDB / ID: 1ddf
TitleFAS DEATH DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE
ComponentsFAS
KeywordsDEATH DOMAIN / APOPTOSIS / RECEPTOR / GLYCOPROTEIN / TRANSMEMBRANE
Function / homology
Function and homology information


Fas signaling pathway / cellular response to hyperoxia / tumor necrosis factor receptor activity / FasL/ CD95L signaling / CD95 death-inducing signaling complex / activation-induced cell death of T cells / Regulation by c-FLIP / CASP8 activity is inhibited / Dimerization of procaspase-8 / Caspase activation via Death Receptors in the presence of ligand ...Fas signaling pathway / cellular response to hyperoxia / tumor necrosis factor receptor activity / FasL/ CD95L signaling / CD95 death-inducing signaling complex / activation-induced cell death of T cells / Regulation by c-FLIP / CASP8 activity is inhibited / Dimerization of procaspase-8 / Caspase activation via Death Receptors in the presence of ligand / necroptotic signaling pathway / death-inducing signaling complex / motor neuron apoptotic process / TP53 Regulates Transcription of Death Receptors and Ligands / RIPK1-mediated regulated necrosis / regulation of stress-activated MAPK cascade / positive regulation of reactive oxygen species biosynthetic process / extrinsic apoptotic signaling pathway via death domain receptors / extrinsic apoptotic signaling pathway / cellular response to amino acid starvation / positive regulation of apoptotic signaling pathway / kinase binding / cellular response to mechanical stimulus / signaling receptor activity / protein-containing complex assembly / regulation of apoptotic process / calmodulin binding / nuclear body / immune response / positive regulation of apoptotic process / membrane raft / external side of plasma membrane / apoptotic process / negative regulation of apoptotic process / cell surface / signal transduction / extracellular exosome / identical protein binding / plasma membrane / cytosol
Similarity search - Function
Fas receptor / Fas receptor, death domain / Fas receptor, N-terminal / TNFR/NGFR family cysteine-rich region domain profile. / TNFR/NGFR cysteine-rich region / TNFR/NGFR family cysteine-rich region signature. / Death Domain, Fas / Tumor necrosis factor receptor / nerve growth factor receptor repeats. / Death Domain, Fas / TNFR/NGFR cysteine-rich region ...Fas receptor / Fas receptor, death domain / Fas receptor, N-terminal / TNFR/NGFR family cysteine-rich region domain profile. / TNFR/NGFR cysteine-rich region / TNFR/NGFR family cysteine-rich region signature. / Death Domain, Fas / Tumor necrosis factor receptor / nerve growth factor receptor repeats. / Death Domain, Fas / TNFR/NGFR cysteine-rich region / Death domain profile. / DEATH domain, found in proteins involved in cell death (apoptosis). / Death domain / Death domain / Death-like domain superfamily / Orthogonal Bundle / Mainly Alpha
Similarity search - Domain/homology
Tumor necrosis factor receptor superfamily member 6
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodSOLUTION NMR
AuthorsHuang, B. / Eberstadt, M. / Olejniczak, E. / Meadows, R.P. / Fesik, S.
CitationJournal: Nature / Year: 1996
Title: NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain.
Authors: Huang, B. / Eberstadt, M. / Olejniczak, E.T. / Meadows, R.P. / Fesik, S.W.
History
DepositionNov 8, 1996Processing site: BNL
Revision 1.0Nov 12, 1997Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Feb 16, 2022Group: Database references / Derived calculations / Other
Category: database_2 / pdbx_database_status ...database_2 / pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.process_site
Revision 1.4May 22, 2024Group: Data collection / Category: chem_comp_atom / chem_comp_bond

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: FAS


Theoretical massNumber of molelcules
Total (without water)14,5351
Polymers14,5351
Non-polymers00
Water00
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)1 / -
Representative

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Components

#1: Protein FAS


Mass: 14535.483 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human)
Description: METHIONINE RESIDUE ADDED TO N-TERMINUS, AN LEHHHHHH HISTIDINE TAG WAS ADDED AT THE C-TERMINUS FOR EASE OF PURIFICATION
Organ: FETAL LIVER / Production host: Escherichia coli (E. coli) / Strain (production host): HMS174 (DE3) / References: UniProt: P25445

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Sample preparation

Sample conditionspH: 4 / Temperature units: K
Crystal grow
*PLUS
Method: other / Details: NMR

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Processing

Software
NameVersionClassification
X-PLOR3.1model building
X-PLOR3.1refinement
X-PLOR3.1phasing
NMR softwareName: X-PLOR / Version: 3.1 / Developer: BRUNGER / Classification: refinement
NMR ensembleConformers submitted total number: 1

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