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データを開く
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基本情報
登録情報 | データベース: PDB / ID: 1dc2 | ||||||
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タイトル | SOLUTION NMR STRUCTURE OF TUMOR SUPPRESSOR P16INK4A, 20 STRUCTURES | ||||||
![]() | CYCLIN-DEPENDENT KINASE 4 INHIBITOR A (P16INK4A) | ||||||
![]() | GENE REGULATION / ANKYRIN REPEAT / HELIX-TURN-HELIX / HELIX BUNDLE | ||||||
機能・相同性 | ![]() senescence-associated heterochromatin focus / positive regulation of macrophage apoptotic process / Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 / Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 / Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 / Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 / positive regulation of smooth muscle cell apoptotic process / negative regulation of cyclin-dependent protein serine/threonine kinase activity / negative regulation of phosphorylation / cyclin-dependent protein serine/threonine kinase inhibitor activity ...senescence-associated heterochromatin focus / positive regulation of macrophage apoptotic process / Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 / Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 / Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 / Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 / positive regulation of smooth muscle cell apoptotic process / negative regulation of cyclin-dependent protein serine/threonine kinase activity / negative regulation of phosphorylation / cyclin-dependent protein serine/threonine kinase inhibitor activity / Regulation of MITF-M-dependent genes involved in cell cycle and proliferation / negative regulation of NF-kappaB transcription factor activity / negative regulation of cell-matrix adhesion / regulation of G1/S transition of mitotic cell cycle / Transcriptional Regulation by VENTX / NF-kappaB binding / replicative senescence / Cyclin D associated events in G1 / Oncogene Induced Senescence / cellular senescence / negative regulation of cell growth / Senescence-Associated Secretory Phenotype (SASP) / Ras protein signal transduction / Oxidative Stress Induced Senescence / regulation of cell cycle / negative regulation of cell population proliferation / negative regulation of DNA-templated transcription / protein kinase binding / RNA binding / nucleus / cytoplasm / cytosol 類似検索 - 分子機能 | ||||||
生物種 | ![]() | ||||||
手法 | 溶液NMR / simulated annealing | ||||||
Model type details | minimized average | ||||||
![]() | Byeon, I.-J.L. / Li, J. / Yuan, C. / Tsai, M.-D. | ||||||
![]() | ![]() タイトル: Tumor suppressor INK4: refinement of p16INK4A structure and determination of p15INK4B structure by comparative modeling and NMR data. 著者: Yuan, C. / Selby, T.L. / Li, J. / Byeon, I.J. / Tsai, M.D. #1: ![]() タイトル: Tumor Suppressor p16INK4A: Determination of Solution Structure and Analyses of Its Interaction with Cyclin-Dependent Kinase 4 著者: Byeon, I.-J. / Li, J. / Ericson, K. / Selby, T.L. / Tevelev, A. / Kim, H.J. / O'Maille, P. / Tsai, M.-D. | ||||||
履歴 |
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構造の表示
構造ビューア | 分子: ![]() ![]() |
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アーカイブディレクトリ | ![]() ![]() | HTTPS FTP |
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-関連構造データ
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リンク
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集合体
登録構造単位 | ![]()
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NMR アンサンブル |
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要素
#1: タンパク質 | 分子量: 16554.641 Da / 分子数: 1 / 由来タイプ: 組換発現 / 由来: (組換発現) ![]() ![]() ![]() |
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-実験情報
-実験
実験 | 手法: 溶液NMR | ||||||||||||||||||||||||||||
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NMR実験 |
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NMR実験の詳細 | Text: THE STRUCTURE WAS DETERMINED USING TRIPLE RESONANCE NMR SPECTROSCOPY. |
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試料調製
詳細 |
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試料状態 | イオン強度: 0 / pH: 7.5 / 圧: AMBIENT / 温度: 293 K | ||||||||
結晶化 | *PLUS 手法: other / 詳細: NMR |
-NMR測定
NMRスペクトロメーター |
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解析
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精密化 | 手法: simulated annealing / ソフトェア番号: 1 詳細: THE STRUCTURES ARE BASED ON A TOTAL OF 1439 RESTRAINTS, 1372 DISTANCE RESTRAINTS, 67 TORSION ANGLE RESTRAINTS. | ||||||||||||||||||||||||
代表構造 | 選択基準: minimized average structure | ||||||||||||||||||||||||
NMRアンサンブル | コンフォーマー選択の基準: THE CLOSEST TO MEAN STRUCTURE WHICH SHOWS GOOD AGREEMENT WITH THE EXPERIMENTAL RESTRAINTS 計算したコンフォーマーの数: 60 / 登録したコンフォーマーの数: 20 |