登録情報 | データベース: PDB / ID: 1d4y |
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タイトル | HIV-1 PROTEASE TRIPLE MUTANT/TIPRANAVIR COMPLEX |
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要素 | PROTEIN (HIV-1 PROTEASE) |
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キーワード | HYDROLASE (加水分解酵素) / ACID PROTEASE (プロテアーゼ) / ASPARTYL PROTEASE (アスパラギン酸プロテアーゼ) |
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機能・相同性 | 機能・相同性情報
RNA stem-loop binding / 宿主 / HIV-1 retropepsin / retroviral ribonuclease H / exoribonuclease H / exoribonuclease H activity / host multivesicular body / DNA integration / 逆転写酵素 / viral genome integration into host DNA ...RNA stem-loop binding / 宿主 / HIV-1 retropepsin / retroviral ribonuclease H / exoribonuclease H / exoribonuclease H activity / host multivesicular body / DNA integration / 逆転写酵素 / viral genome integration into host DNA / viral penetration into host nucleus / establishment of integrated proviral latency / RNA-directed DNA polymerase activity / RNA-DNA hybrid ribonuclease activity / 転移酵素; リンを含む基を移すもの; 核酸を移すもの / symbiont-mediated suppression of host gene expression / viral nucleocapsid / DNA recombination / 加水分解酵素; エステル加水分解酵素 / DNAポリメラーゼ / aspartic-type endopeptidase activity / DNA-directed DNA polymerase activity / symbiont entry into host cell / lipid binding / host cell nucleus / host cell plasma membrane / virion membrane / structural molecule activity / タンパク質分解 / DNA binding / zinc ion binding / 生体膜類似検索 - 分子機能 Reverse transcriptase connection / Reverse transcriptase connection domain / Reverse transcriptase thumb / Reverse transcriptase thumb domain / Integrase Zinc binding domain / Zinc finger integrase-type profile. / Integrase-like, N-terminal / Integrase DNA binding domain / Integrase, C-terminal domain superfamily, retroviral / Integrase, N-terminal zinc-binding domain ...Reverse transcriptase connection / Reverse transcriptase connection domain / Reverse transcriptase thumb / Reverse transcriptase thumb domain / Integrase Zinc binding domain / Zinc finger integrase-type profile. / Integrase-like, N-terminal / Integrase DNA binding domain / Integrase, C-terminal domain superfamily, retroviral / Integrase, N-terminal zinc-binding domain / Integrase, C-terminal, retroviral / Integrase DNA binding domain profile. / Immunodeficiency lentiviral matrix, N-terminal / gag gene protein p17 (matrix protein) / リボヌクレアーゼH / Integrase core domain / Integrase, catalytic core / Integrase catalytic domain profile. / Retroviral nucleocapsid Gag protein p24, C-terminal domain / Gag protein p24 C-terminal domain / Retropepsin-like catalytic domain / Matrix protein, lentiviral and alpha-retroviral, N-terminal / Ribonuclease H domain / RNase H type-1 domain profile. / Reverse transcriptase (RNA-dependent DNA polymerase) / Reverse transcriptase domain / Reverse transcriptase (RT) catalytic domain profile. / Retropepsins / Retroviral aspartyl protease / Aspartyl protease, retroviral-type family profile. / Peptidase A2A, retrovirus, catalytic / Retrovirus capsid, C-terminal / Retroviral matrix protein / Retrovirus capsid, N-terminal / ジンクフィンガー / Zinc knuckle / Zinc finger, CCHC-type superfamily / Cathepsin D, subunit A; domain 1 / Acid Proteases / Zinc finger, CCHC-type / Zinc finger CCHC-type profile. / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Ribonuclease H superfamily / Aspartic peptidase domain superfamily / Ribonuclease H-like superfamily / Reverse transcriptase/Diguanylate cyclase domain / DNA/RNA polymerase superfamily / Βバレル / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Human immunodeficiency virus 1 (ヒト免疫不全ウイルス) |
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手法 | X線回折 / 分子置換 / 解像度: 1.97 Å |
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データ登録者 | Watenpaugh, K.D. / Janakiraman, M.N. |
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引用 | ジャーナル: J.Med.Chem. / 年: 1996 タイトル: Structure-based design of HIV protease inhibitors: sulfonamide-containing 5,6-dihydro-4-hydroxy-2-pyrones as non-peptidic inhibitors. 著者: Thaisrivongs, S. / Skulnick, H.I. / Turner, S.R. / Strohbach, J.W. / Tommasi, R.A. / Johnson, P.D. / Aristoff, P.A. / Judge, T.M. / Gammill, R.B. / Morris, J.K. / Romines, K.R. / Chrusciel, R. ...著者: Thaisrivongs, S. / Skulnick, H.I. / Turner, S.R. / Strohbach, J.W. / Tommasi, R.A. / Johnson, P.D. / Aristoff, P.A. / Judge, T.M. / Gammill, R.B. / Morris, J.K. / Romines, K.R. / Chrusciel, R.A. / Hinshaw, R.R. / Chong, K.T. / Tarpley, W.G. / Poppe, S.M. / Slade, D.E. / Lynn, J.C. / Horng, M.M. / Tomich, P.K. / Seest, E.P. / Dolak, L.A. / Howe, W.J. / Howard, G.M. / Watenpaugh, K.D. |
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履歴 | 登録 | 1999年10月6日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 1999年10月13日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年4月27日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 1.3 | 2012年2月22日 | Group: Database references |
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改定 1.4 | 2017年10月4日 | Group: Refinement description / カテゴリ: software / Item: _software.name |
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改定 1.5 | 2021年11月3日 | Group: Database references / Derived calculations / カテゴリ: database_2 / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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改定 1.6 | 2024年2月7日 | Group: Data collection / カテゴリ: chem_comp_atom / chem_comp_bond |
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