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- PDB-1czy: CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE TRAF DOMAIN OF HUMAN... -
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Open data
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Basic information
Entry | Database: PDB / ID: 1czy | ||||||
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Title | CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE TRAF DOMAIN OF HUMAN TRAF2 AND AN LMP1 BINDING PEPTIDE | ||||||
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![]() | APOPTOSIS / BETA SANDWICH / PROTEIN-PEPTIDE COMPLEX / SIGNALING PROTEIN | ||||||
Function / homology | ![]() : / CD40 receptor binding / tumor necrosis factor receptor superfamily complex / sphingolipid binding / symbiont-mediated suppression of host TRAF-mediated signal transduction => GO:0039527 / IRE1-TRAF2-ASK1 complex / Defective RIPK1-mediated regulated necrosis / TRAF2-GSTP1 complex / negative regulation of glial cell apoptotic process / Regulation by c-FLIP ...: / CD40 receptor binding / tumor necrosis factor receptor superfamily complex / sphingolipid binding / symbiont-mediated suppression of host TRAF-mediated signal transduction => GO:0039527 / IRE1-TRAF2-ASK1 complex / Defective RIPK1-mediated regulated necrosis / TRAF2-GSTP1 complex / negative regulation of glial cell apoptotic process / Regulation by c-FLIP / CASP8 activity is inhibited / Dimerization of procaspase-8 / tumor necrosis factor binding / TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway / interleukin-17-mediated signaling pathway / programmed necrotic cell death / TNF signaling / Caspase activation via Death Receptors in the presence of ligand / CD40 receptor complex / signal transduction involved in regulation of gene expression / activation of NF-kappaB-inducing kinase activity / vesicle membrane / mitogen-activated protein kinase kinase kinase binding / positive regulation of tumor necrosis factor-mediated signaling pathway / mRNA stabilization / thioesterase binding / tumor necrosis factor receptor binding / positive regulation of extrinsic apoptotic signaling pathway / regulation of immunoglobulin production / TNFR1-induced proapoptotic signaling / RIPK1-mediated regulated necrosis / TRAF6 mediated IRF7 activation / transformation of host cell by virus / non-canonical NF-kappaB signal transduction / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity / TRAF6 mediated NF-kB activation / protein K63-linked ubiquitination / regulation of JNK cascade / host cell membrane / intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress / cellular response to nitric oxide / regulation of protein-containing complex assembly / protein autoubiquitination / signaling adaptor activity / ubiquitin ligase complex / positive regulation of JUN kinase activity / tumor necrosis factor-mediated signaling pathway / positive regulation of interleukin-2 production / response to endoplasmic reticulum stress / TNFR1-induced NF-kappa-B signaling pathway / Regulation of NF-kappa B signaling / TNFR2 non-canonical NF-kB pathway / Regulation of TNFR1 signaling / protein catabolic process / RING-type E3 ubiquitin transferase / Regulation of necroptotic cell death / cytoplasmic side of plasma membrane / positive regulation of T cell cytokine production / positive regulation of DNA-binding transcription factor activity / ubiquitin-protein transferase activity / protein-macromolecule adaptor activity / positive regulation of NF-kappaB transcription factor activity / cell cortex / protein-containing complex assembly / regulation of apoptotic process / protein phosphatase binding / positive regulation of canonical NF-kappaB signal transduction / membrane => GO:0016020 / molecular adaptor activity / Ub-specific processing proteases / symbiont-mediated suppression of host type I interferon-mediated signaling pathway / membrane raft / innate immune response / ubiquitin protein ligase binding / protein-containing complex binding / protein kinase binding / host cell plasma membrane / enzyme binding / signal transduction / zinc ion binding / nucleoplasm / identical protein binding / cytoplasm / cytosol Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() | ||||||
![]() | Ye, H. / Park, Y.C. / Kreishman, M. / Kieff, E. / Wu, H. | ||||||
![]() | ![]() Title: The structural basis for the recognition of diverse receptor sequences by TRAF2. Authors: Ye, H. / Park, Y.C. / Kreishman, M. / Kieff, E. / Wu, H. #1: ![]() Title: Structural Basis for Self-Association and Receptor Recognition of Human Traf2 Authors: Park, Y.C. / Burkitt, V. / Villa, A.R. / Tong, L. / Wu, H. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 113.4 KB | Display | ![]() |
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PDB format | ![]() | 91.5 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
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-Validation report
Summary document | ![]() | 389.3 KB | Display | ![]() |
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Full document | ![]() | 398.6 KB | Display | |
Data in XML | ![]() | 12.8 KB | Display | |
Data in CIF | ![]() | 20.6 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
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Links
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Assembly
Deposited unit | ![]()
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Unit cell |
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Components
#1: Protein | Mass: 19032.953 Da / Num. of mol.: 3 / Fragment: TRAF DOMAIN Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() #2: Protein/peptide | Mass: 799.783 Da / Num. of mol.: 2 / Fragment: TRAF2-BINDING REGION / Source method: obtained synthetically Details: THIS PEPTIDE WAS CHEMICALLY SYNTHESIZED. THE SEQUENCE OF THIS PEPTIDE NATURALLY OCCURS IN HUMANS (HOMO SAPIENS) References: UniProt: P03230 #3: Water | ChemComp-HOH / | Compound details | THE DEPOSITED TRAF2-RECEPTOR PEPTIDE COMPLEX CONTAINS 3 TRAF2 PER ASYMMETRIC UNIT, ONE OF WHICH ...THE DEPOSITED TRAF2-RECEPTOR PEPTIDE COMPLEX CONTAINS 3 TRAF2 PER ASYMMETRIC | |
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-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 2.45 Å3/Da / Density % sol: 49.89 % | |||||||||||||||
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Crystal grow | Temperature: 293 K / Method: vapor diffusion / pH: 6 Details: PEG4K, MES BUFFER, pH 6.00, VAPOR DIFFUSION, temperature 20K | |||||||||||||||
Crystal grow | *PLUS Method: unknown | |||||||||||||||
Components of the solutions | *PLUS
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-Data collection
Diffraction | Mean temperature: 100 K |
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Diffraction source | Source: ![]() ![]() ![]() |
Detector | Type: RIGAKU RAXIS IV / Detector: IMAGE PLATE |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength: 1.018 Å / Relative weight: 1 |
Reflection | *PLUS Highest resolution: 2 Å / % possible obs: 99.7 % / Rmerge(I) obs: 0.055 |
Reflection shell | *PLUS % possible obs: 100 % / Rmerge(I) obs: 0.15 |
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Processing
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Refinement | Resolution: 2→20 Å
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Refinement step | Cycle: LAST / Resolution: 2→20 Å
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