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- PDB-1cxn: REFINED THREE-DIMENSIONAL SOLUTION STRUCTURE OF A SNAKE CARDIOTOX... -

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Basic information

Entry
Database: PDB / ID: 1cxn
TitleREFINED THREE-DIMENSIONAL SOLUTION STRUCTURE OF A SNAKE CARDIOTOXIN: ANALYSIS OF THE SIDE-CHAIN ORGANISATION SUGGESTS THE EXISTENCE OF A POSSIBLE PHOSPHOLIPID BINDING SITE
ComponentsCARDIOTOXIN GAMMA
KeywordsCYTOTOXIN
Function / homology
Function and homology information


other organism cell membrane / toxin activity / killing of cells of another organism / extracellular region / membrane
Similarity search - Function
Snake cytotoxin, cobra-type / Snake toxin, conserved site / Snake toxins signature. / Snake three-finger toxin / : / Snake toxin cobra-type / CD59 / CD59 / Snake toxin-like superfamily / Ribbon / Mainly Beta
Similarity search - Domain/homology
Biological speciesNaja nigricollis (spitting cobra)
MethodSOLUTION NMR
AuthorsGilquin, B. / Roumestand, C. / Zinn-Justin, S. / Menez, A. / Toma, F.
Citation
Journal: Biopolymers / Year: 1993
Title: Refined three-dimensional solution structure of a snake cardiotoxin: analysis of the side-chain organization suggests the existence of a possible phospholipid binding site.
Authors: Gilquin, B. / Roumestand, C. / Zinn-Justin, S. / Menez, A. / Toma, F.
#1: Journal: To be Published
Title: Proton NMR Studies of the Structural and Dynamical Effects of Chemical Modification of Single Aromatic Side Chain in a Snake Cardiotoxin: Relation with the Structure of the Putative Binding ...Title: Proton NMR Studies of the Structural and Dynamical Effects of Chemical Modification of Single Aromatic Side Chain in a Snake Cardiotoxin: Relation with the Structure of the Putative Binding Site and the Cytolitic Activity of the Toxin
Authors: Roumestand, C. / Gilquin, B. / Tremeau, O. / Gatineau, E. / Mouawad, L. / Menez, A. / Toma, F.
History
DepositionJul 8, 1994Processing site: BNL
Revision 1.0Dec 20, 1994Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Feb 16, 2022Group: Database references / Derived calculations / Other
Category: database_2 / pdbx_database_status ...database_2 / pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.process_site
Revision 1.4Oct 23, 2024Group: Data collection / Structure summary
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / pdbx_entry_details / pdbx_modification_feature

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Assembly

Deposited unit
A: CARDIOTOXIN GAMMA


Theoretical massNumber of molelcules
Total (without water)6,8381
Polymers6,8381
Non-polymers00
Water00
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)1 / -
Representative

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Components

#1: Protein CARDIOTOXIN GAMMA


Mass: 6838.462 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Naja nigricollis (spitting cobra) / References: UniProt: P01468
Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Processing

Software
NameClassification
X-PLORmodel building
X-PLORrefinement
X-PLORphasing
NMR softwareName: X-PLOR / Developer: BRUNGER / Classification: refinement
NMR ensembleConformers submitted total number: 1

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