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基本情報
登録情報 | データベース: PDB / ID: 1a5r | ||||||
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タイトル | STRUCTURE DETERMINATION OF THE SMALL UBIQUITIN-RELATED MODIFIER SUMO-1, NMR, 10 STRUCTURES | ||||||
![]() | SUMO-1 | ||||||
![]() | TARGETING PROTEIN / SUMO-1 / POST-TRANSLATIONAL PROTEIN MODIFICATION / UBIQUITIN-LIKE PROTEINS | ||||||
機能・相同性 | ![]() protein localization to nuclear pore / negative regulation of transcription by transcription factor localization / SUMOylation of nuclear envelope proteins / Negative regulation of activity of TFAP2 (AP-2) family transcription factors / SUMO is proteolytically processed / negative regulation of delayed rectifier potassium channel activity / SUMO is conjugated to E1 (UBA2:SAE1) / nuclear stress granule / PML body organization / SUMO is transferred from E1 to E2 (UBE2I, UBC9) ...protein localization to nuclear pore / negative regulation of transcription by transcription factor localization / SUMOylation of nuclear envelope proteins / Negative regulation of activity of TFAP2 (AP-2) family transcription factors / SUMO is proteolytically processed / negative regulation of delayed rectifier potassium channel activity / SUMO is conjugated to E1 (UBA2:SAE1) / nuclear stress granule / PML body organization / SUMO is transferred from E1 to E2 (UBE2I, UBC9) / negative regulation of action potential / small protein activating enzyme binding / septin ring / regulation of calcium ion transmembrane transport / SUMOylation of DNA methylation proteins / SUMOylation of immune response proteins / XY body / SUMOylation of SUMOylation proteins / Maturation of nucleoprotein / SUMOylation of RNA binding proteins / regulation of cardiac muscle cell contraction / Postmitotic nuclear pore complex (NPC) reformation / Maturation of nucleoprotein / negative regulation of protein import into nucleus / roof of mouth development / SUMOylation of ubiquitinylation proteins / ubiquitin-specific protease binding / negative regulation of DNA binding / ubiquitin-like protein ligase binding / SUMOylation of DNA replication proteins / transcription factor binding / SUMOylation of transcription factors / protein sumoylation / potassium channel regulator activity / SUMOylation of DNA damage response and repair proteins / Regulation of IFNG signaling / nuclear pore / cellular response to cadmium ion / SUMOylation of chromatin organization proteins / SUMOylation of transcription cofactors / SUMOylation of intracellular receptors / positive regulation of protein-containing complex assembly / PKR-mediated signaling / negative regulation of DNA-binding transcription factor activity / PML body / Formation of Incision Complex in GG-NER / protein tag activity / regulation of protein localization / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / cellular response to heat / nuclear membrane / nuclear body / protein stabilization / nuclear speck / DNA repair / negative regulation of DNA-templated transcription / ubiquitin protein ligase binding / nucleolus / enzyme binding / RNA binding / nucleoplasm / nucleus / plasma membrane / cytosol 類似検索 - 分子機能 | ||||||
生物種 | ![]() | ||||||
手法 | 溶液NMR / simulated annealing | ||||||
![]() | Bayer, P. / Arndt, A. / Metzger, S. / Mahajan, R. / Melchior, F. / Jaenicke, R. / Becker, J. | ||||||
![]() | ![]() タイトル: Structure determination of the small ubiquitin-related modifier SUMO-1. 著者: Bayer, P. / Arndt, A. / Metzger, S. / Mahajan, R. / Melchior, F. / Jaenicke, R. / Becker, J. #1: ![]() タイトル: A Small Ubiquitin-Related Polypeptide Involved in Targeting Rangap1 to Nuclear Pore Complex Protein Ranbp2 著者: Mahajan, R. / Delphin, C. / Guan, T. / Gerace, L. / Melchior, F. #2: ![]() タイトル: Preferential Modification of Nuclear Proteins by a Novel Ubiquitin-Like Molecule 著者: Kamitani, T. / Nguyen, H.P. / Yeh, E.T. #3: ![]() タイトル: A Novel Ubiquitin-Like Modification Modulates the Partitioning of the Ran-Gtpase-Activating Protein Rangap1 between the Cytosol and the Nuclear Pore Complex 著者: Matunis, M.J. / Coutavas, E. / Blobel, G. | ||||||
履歴 |
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構造の表示
構造ビューア | 分子: ![]() ![]() |
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PDBx/mmCIF形式 | ![]() | 319.1 KB | 表示 | ![]() |
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PDB形式 | ![]() | 265.4 KB | 表示 | ![]() |
PDBx/mmJSON形式 | ![]() | ツリー表示 | ![]() | |
その他 | ![]() |
-検証レポート
文書・要旨 | ![]() | 343.9 KB | 表示 | ![]() |
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文書・詳細版 | ![]() | 465.8 KB | 表示 | |
XML形式データ | ![]() | 38.5 KB | 表示 | |
CIF形式データ | ![]() | 51.1 KB | 表示 | |
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-関連構造データ
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リンク
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集合体
登録構造単位 | ![]()
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NMR アンサンブル |
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要素
#1: タンパク質 | 分子量: 11719.133 Da / 分子数: 1 / 由来タイプ: 組換発現 / 由来: (組換発現) ![]() ![]() ![]() |
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-実験情報
-実験
実験 | 手法: 溶液NMR | ||||||||||||||||||||||||||||
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NMR実験 |
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試料調製
詳細 | 内容: H2O |
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試料状態 | イオン強度: 100 mM / pH: 7.0 / 圧: STANDARD / 温度: 300 K |
結晶化 | *PLUS 手法: other / 詳細: NMR |
-NMR測定
NMRスペクトロメーター | タイプ: Bruker DRX / 製造業者: Bruker / モデル: DRX / 磁場強度: 500 MHz |
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解析
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精密化 | 手法: simulated annealing / ソフトェア番号: 1 | ||||||||||||||||
NMRアンサンブル | コンフォーマー選択の基準: ENERGY / 計算したコンフォーマーの数: 30 / 登録したコンフォーマーの数: 10 |