EMDB-67263: Human minor spliceosome exon-ligation-ready C* complex (prior to ...

Basic information

Entry

Database: EMDB / ID: EMD-67263

• Title: Human minor spliceosome exon-ligation-ready C* complex (prior to step-II)
• Map data: overall map of the human minor C* complex

Sample

• Complex: Human minor spliceosome exon-ligation-ready C* complex (prior to step-II)
  • RNA: x 5 types
  • Protein or peptide: x 49 types
• Ligand: x 8 types

• Keywords: minor spliceosome / U12-dependent spliceosome / U12-type splicing / step-II / SPLICING / exon ligation / snRNP / U12 / U5 / U6atac / intron lariat / splice site / exon

Function / homology

Function:

U12 snRNA binding / second spliceosomal transesterification activity / exon-exon junction subcomplex mago-y14 / negative regulation of selenocysteine incorporation / cellular response to selenite ion / Lsm2-8 complex / U6 snRNA 3'-end binding / post-spliceosomal complex / exon-exon junction complex / regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / regulation of vitamin D receptor signaling pathway / pre-mRNA 3'-splice site binding / selenocysteine insertion sequence binding / mRNA decay by 5' to 3' exoribonuclease / Lsm1-7-Pat1 complex / mRNA metabolic process / regulation of translation at postsynapse, modulating synaptic transmission / U6 snRNP / regulation of retinoic acid receptor signaling pathway / PH domain binding / alternative mRNA splicing, via spliceosome / negative regulation of toll-like receptor signaling pathway / post-mRNA release spliceosomal complex / U2 snRNP binding / U7 snRNA binding / histone pre-mRNA DCP binding / generation of catalytic spliceosome for first transesterification step / U7 snRNP / 3'-5' RNA helicase activity / Z-decay: degradation of maternal mRNAs by zygotically expressed factors / cis assembly of pre-catalytic spliceosome / histone pre-mRNA 3'end processing complex / deadenylation-dependent decapping of nuclear-transcribed mRNA / nuclear histone mRNA catabolic process / negative regulation of lipopolysaccharide-mediated signaling pathway / embryonic cranial skeleton morphogenesis / SLBP independent Processing of Histone Pre-mRNAs / regulation of mRNA processing / SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs / Deadenylation of mRNA / negative regulation of interleukin-8 production / negative regulation of interferon-beta production / negative regulation of excitatory postsynaptic potential / positive regulation of alpha-beta T cell differentiation / embryonic brain development / poly(A) binding / 7-methylguanosine cap hypermethylation / U12-type spliceosomal complex / positive regulation of mRNA splicing, via spliceosome / nuclear retinoic acid receptor binding / U1 snRNP binding / C2H2 zinc finger domain binding / pICln-Sm protein complex / U2-type catalytic step 1 spliceosome / methylosome / regulation of mRNA splicing, via spliceosome / ATP-dependent activity, acting on RNA / RNA splicing, via transesterification reactions / mRNA 3'-end processing / sno(s)RNA-containing ribonucleoprotein complex / small nuclear ribonucleoprotein complex / M-decay: degradation of maternal mRNAs by maternally stored factors / SMN-Sm protein complex / spliceosomal tri-snRNP complex / positive regulation of vitamin D receptor signaling pathway / commitment complex / P granule / U4 snRNP / snRNP binding / host-mediated activation of viral transcription / U2-type precatalytic spliceosome / mRNA cis splicing, via spliceosome / Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells / U2-type prespliceosome assembly / RUNX3 regulates NOTCH signaling / U2-type catalytic step 2 spliceosome / Notch binding / U2-type spliceosomal complex / nuclear vitamin D receptor binding / telomerase holoenzyme complex / Transport of Mature mRNA derived from an Intron-Containing Transcript / NOTCH4 Intracellular Domain Regulates Transcription / telomerase RNA binding / exploration behavior / positive regulation of neurogenesis / U1 snRNP / U2 snRNP / spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) / negative regulation of type I interferon-mediated signaling pathway / RNA Polymerase II Transcription Termination / P-body assembly / NOTCH3 Intracellular Domain Regulates Transcription / nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / protein methylation / mRNA stabilization / U2-type prespliceosome / tRNA processing / protein peptidyl-prolyl isomerization / K63-linked polyubiquitin modification-dependent protein binding / nuclear androgen receptor binding

Domain/homology:

Protein FAM204A / : / RBM48, RNA recognition motif / RNA-binding protein 48 / Armadillo repeat-containing protein 7 / RNA-binding region-containing protein RBM41/RNPC3 / : / RNA-binding protein 48 helical domain / NF-kappa-B-activating protein, C-terminal / NF-kappa-B-activating protein / NF-kappa-B-activating protein C-terminal domain / NF-kappa-B-activating protein / Protein FAM32A / Cactin, central domain / Cactin, C-terminal / FAM32A / Cactus-binding C-terminus of cactin protein / Conserved mid region of cactin / Nuclear protein DGCR14/ESS-2 / Nuclear protein Es2 / mRNA splicing factor Cwf18-like / cwf18 pre-mRNA splicing factor / Pre-mRNA-splicing factor SLU7 domain / Pre-mRNA-splicing factor SLU7 / Pre-mRNA splicing Prp18-interacting factor / DHX8/ Prp22, DEXH-box helicase domain / Mago nashi protein / RNA-binding motif protein 8 / RBM8, RNA recognition motif / Mago nashi superfamily / : / : / Mago nashi protein / Pre-mRNA-splicing factor Isy1 / Pre-mRNA-splicing factor Isy1 superfamily / Isy1-like splicing family / : / Prp19 WD40 domain / : / : / Intron-binding protein aquarius, beta-barrel / Intron-binding protein aquarius insert domain / Peptidyl-prolyl cis-trans isomerase E / Peptidyl-prolyl cis-trans isomerase E, RNA recognition motif / Sm-like protein Lsm8 / Pre-mRNA-splicing factor SPF27 / Breast carcinoma amplified sequence 2 (BCAS2) / U6 snRNA-associated Sm-like protein LSm2 / Sm-like protein Lsm4 / Sm-like protein Lsm7 / U6 snRNA-associated Sm-like protein Lsm1/8 / Sm-like protein LSm5 / Sm-like protein Lsm3 / U6 snRNA-associated Sm-like protein Lsm3 / CWF11 family / Intron-binding protein aquarius, N-terminal / Intron-binding protein aquarius N-terminal / Helix hairpin bin domain superfamily / Cactus-binding C-terminus of cactin protein / : / : / mRNA splicing factor Cwf21 domain / cwf21 domain / UPF1-type helicase core domain profile. / Pre-mRNA-splicing factor 19 / Pre-mRNA-processing factor 19 / : / Prp19/Pso4-like / : / Pre-mRNA-splicing factor SYF1 middle HAT repeat / Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like / : / Pre-mRNA-splicing factor Syf1/CRNKL1 C-terminal HAT repeat / DNA2/NAM7 helicase, helicase domain / AAA domain / U-box domain / SKI-interacting protein SKIP, SNW domain / Pre-mRNA-splicing factor Cwf15/Cwc15 / SKI-interacting protein, SKIP / SKIP/SNW domain / Cwf15/Cwc15 cell cycle control protein / WD repeat Prp46/PLRG1-like / : / Initiation factor eIF-4 gamma, MA3 / Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal / : / : / : / MA3 domain / pre-mRNA splicing factor component / Pre-mRNA-splicing factor Syf1/CNRKL1 N-terminal HAT repeat / MI domain profile. / Domain in DAP-5, eIF4G, MA-3 and other proteins. / DNA2/NAM7-like helicase / : / MIF4G domain / Small ribonucleoprotein associated, SmB/SmN / Myb-like DNA-binding domain / Middle domain of eukaryotic initiation factor 4G (eIF4G) / MIF4G-like, type 3

Component:

Pleiotropic regulator 1 / RNA helicase aquarius / U5 small nuclear ribonucleoprotein 200 kDa helicase / Pre-mRNA-splicing factor SPF27 / Pre-mRNA-splicing factor SLU7 / U6 snRNA-associated Sm-like protein LSm8 / Small nuclear ribonucleoprotein-associated proteins B and B' / Eukaryotic initiation factor 4A-III / Protein mago nashi homolog / Small nuclear ribonucleoprotein E / Small nuclear ribonucleoprotein F / Small nuclear ribonucleoprotein G / U6 snRNA-associated Sm-like protein LSm3 / U6 snRNA-associated Sm-like protein LSm6 / Small nuclear ribonucleoprotein Sm D1 / Small nuclear ribonucleoprotein Sm D2 / Small nuclear ribonucleoprotein Sm D3 / SNW domain-containing protein 1 / ATP-dependent RNA helicase DHX8 / 116 kDa U5 small nuclear ribonucleoprotein component / RNA-binding protein 48 / WD repeat-containing protein 25 / Pre-mRNA-processing-splicing factor 8 / NF-kappa-B-activating protein / Coiled-coil domain-containing protein 12 / Splicing factor Cactin / Peptidylprolyl isomerase domain and WD repeat-containing protein 1 / Splicing factor ESS-2 homolog / U5 small nuclear ribonucleoprotein 40 kDa protein / RNA-binding protein 41 / Cell division cycle 5-like protein / Crooked neck-like protein 1 / Peptidyl-prolyl cis-trans isomerase-like 3 / Armadillo repeat-containing protein 7 / Protein FAM204A / Pre-mRNA-splicing factor CWC22 homolog / Pre-mRNA-splicing factor SYF1 / Spliceosome-associated protein CWC15 homolog / U6 snRNA-associated Sm-like protein LSm7 / Pre-mRNA-splicing factor ISY1 homolog / Pre-mRNA-processing factor 19 / Peptidyl-prolyl cis-trans isomerase E / Serine/arginine repetitive matrix protein 2 / U6 snRNA-associated Sm-like protein LSm2 / Peptidyl-prolyl cis-trans isomerase-like 1 / Protein FAM32A / U6 snRNA-associated Sm-like protein LSm5 / U6 snRNA-associated Sm-like protein LSm4 / RNA-binding protein 8A

• Biological species: Homo sapiens (human)
• Method: single particle reconstruction / cryo EM / Resolution: 3.0 Å
• Authors: Wan R / Bai R

Funding support

China, 1 items

Organization	Grant number	Country
National Natural Science Foundation of China (NSFC)	32171214	China

• Citation: Journal: Vita / Year: 2026; Title: Molecular mechanism of the catalysis for U12-type splicing by the human; Authors: Bai R / Guo H / Sun R / Zhu Y / Shi Y / Wan R

History

Deposition	Nov 24, 2025	-
Header (metadata) release	Aug 12, 2026	-
Map release	Aug 12, 2026	-
Update	Aug 12, 2026	-
Current status	Aug 12, 2026	Processing site: PDBc / Status: Released

Map

• File: Download / File: emd_67263.map.gz / Format: CCP4 / Size: 1000 MB / Type: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
• Annotation: overall map of the human minor C* complex
• Voxel size: X=Y=Z: 1.0773 Å

Density

Contour Level	By AUTHOR: 0.36
Minimum - Maximum	-1.2408643 - 2.8793433
Average (Standard dev.)	0.00032579075 (±0.058995027)

• Symmetry: Space group: 1

Details

EMDB XML:

Map geometry	Axis order X Y Z Origin 0 0 0 Dimensions 640 640 640 Spacing 640 640 640
Cell	A=B=C: 689.472 Å α=β=γ: 90.0 °

Supplemental data

Half map: half map 2

• File: emd_67263_half_map_1.map
• Annotation: half map 2

Half map: half map 1

• File: emd_67263_half_map_2.map
• Annotation: half map 1

Sample components

Entire : Human minor spliceosome exon-ligation-ready C* complex (prior to ...

• Entire: Name: Human minor spliceosome exon-ligation-ready C* complex (prior to step-II)

Components

• Complex: Human minor spliceosome exon-ligation-ready C* complex (prior to step-II)
  • RNA: MSE-U12_5 exon
  • RNA: MSE-U12_intron-3 exon
  • RNA: U12 snRNA
  • Protein or peptide: Peptidylprolyl isomerase domain and WD repeat-containing protein 1
  • RNA: U5 snRNA
  • RNA: U6atac snRNA
  • Protein or peptide: Pre-mRNA-processing-splicing factor 8
  • Protein or peptide: 116 kDa U5 small nuclear ribonucleoprotein component
  • Protein or peptide: U5 small nuclear ribonucleoprotein 200 kDa helicase
  • Protein or peptide: U5 small nuclear ribonucleoprotein 40 kDa protein
  • Protein or peptide: Cell division cycle 5-like protein
  • Protein or peptide: Pre-mRNA-splicing factor SYF1
  • Protein or peptide: Crooked neck-like protein 1
  • Protein or peptide: Coiled-coil domain-containing protein 12
  • Protein or peptide: Pre-mRNA-splicing factor ISY1 homolog
  • Protein or peptide: SNW domain-containing protein 1
  • Protein or peptide: Pleiotropic regulator 1
  • Protein or peptide: RNA-binding protein 48
  • Protein or peptide: U6 snRNA-associated Sm-like protein LSm2
  • Protein or peptide: U6 snRNA-associated Sm-like protein LSm3
  • Protein or peptide: U6 snRNA-associated Sm-like protein LSm4
  • Protein or peptide: U6 snRNA-associated Sm-like protein LSm5
  • Protein or peptide: U6 snRNA-associated Sm-like protein LSm6
  • Protein or peptide: U6 snRNA-associated Sm-like protein LSm7
  • Protein or peptide: U6 snRNA-associated Sm-like protein LSm8
  • Protein or peptide: Armadillo repeat-containing protein 7
  • Protein or peptide: Spliceosome-associated protein CWC15 homolog
  • Protein or peptide: Peptidyl-prolyl cis-trans isomerase-like 1
  • Protein or peptide: Peptidyl-prolyl cis-trans isomerase E
  • Protein or peptide: RNA helicase aquarius
  • Protein or peptide: Peptidyl-prolyl cis-trans isomerase-like 3
  • Protein or peptide: Pre-mRNA-splicing factor SLU7
  • Protein or peptide: ATP-dependent RNA helicase DHX8
  • Protein or peptide: Serine/arginine repetitive matrix protein 2
  • Protein or peptide: Pre-mRNA-splicing factor CWC22 homolog
  • Protein or peptide: WD repeat-containing protein 25
  • Protein or peptide: Splicing factor Cactin
  • Protein or peptide: Protein FAM32A
  • Protein or peptide: NF-kappa-B-activating protein
  • Protein or peptide: Small nuclear ribonucleoprotein-associated proteins B and B'
  • Protein or peptide: Small nuclear ribonucleoprotein Sm D1
  • Protein or peptide: Small nuclear ribonucleoprotein Sm D2
  • Protein or peptide: Small nuclear ribonucleoprotein Sm D3
  • Protein or peptide: Small nuclear ribonucleoprotein E
  • Protein or peptide: Small nuclear ribonucleoprotein F
  • Protein or peptide: Small nuclear ribonucleoprotein G
  • Protein or peptide: Splicing factor ESS-2 homolog
  • Protein or peptide: Pre-mRNA-processing factor 19
  • Protein or peptide: Pre-mRNA-splicing factor SPF27
  • Protein or peptide: Eukaryotic initiation factor 4A-III
  • Protein or peptide: Protein mago nashi homolog
  • Protein or peptide: RNA-binding protein 8A
  • Protein or peptide: RNA-binding protein 41
  • Protein or peptide: Protein FAM204A
• Ligand: MAGNESIUM ION
• Ligand: POTASSIUM ION
• Ligand: INOSITOL HEXAKISPHOSPHATE
• Ligand: GUANOSINE-5'-TRIPHOSPHATE
• Ligand: ADENOSINE-5'-DIPHOSPHATE
• Ligand: ZINC ION
• Ligand: ADENOSINE-5'-TRIPHOSPHATE
• Ligand: water

Supramolecule #1: Human minor spliceosome exon-ligation-ready C* complex (prior to ...

• Supramolecule: Name: Human minor spliceosome exon-ligation-ready C* complex (prior to step-II); type: complex / ID: 1 / Parent: 0 / Macromolecule list: #1-#54
• Source (natural): Organism: Homo sapiens (human)

Macromolecule #1: MSE-U12_5 exon

• Macromolecule: Name: MSE-U12_5 exon / type: rna / ID: 1 / Number of copies: 1
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 18.256914 KDa

Sequence

String:

GAAUACACGG AAUUCGAGCU CGCCCACUCU UGGAUCGGAA ACCCGUCGGC CUCCAAG

Macromolecule #2: MSE-U12_intron-3 exon

• Macromolecule: Name: MSE-U12_intron-3 exon / type: rna / ID: 2 / Number of copies: 1
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 88.640148 KDa

Sequence

String:

AUAUCCUUUU UAAGCAUGUA GAACUGGUUA CCUGCAGCCC AAGCUUGCUG CGAUAUCCGU ACACCAUCAG GGUACGAGCU AGCCCAUGG CGUACACCAU CAGGGUACGA CUAGUAGAUC UCGUACACCA UCAGGGUACG GAAUUCUCUA GACACGUCUA G GGCGCAGU AGUCCAGGGU UUCCUUGAUG AUGUUUUUCC UUAACUGCAA CUUUGCUCAC GCUGUUCAGC AUGUUCAUCA UG AUCACCA UCUUGACCAA CUGCAGGAUC CGGAAGAAUU

Macromolecule #3: U12 snRNA

• Macromolecule: Name: U12 snRNA / type: rna / ID: 3 / Number of copies: 1
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 48.353625 KDa

Sequence

String:

AUGCCUUAAA CUUAUGAGUA AGGAAAAUAA CGAUUCGGGG UGACGCCCGA AUCCUCACUG CUAAUGUGAG ACGAAUUUUU GAGCGGGUA AAGGUCGCCC UCAAGGUGAC CCGCCUACUU UGCGGGAUGC CUGGGAGUUG CGAUCUGCCC G

Macromolecule #5: U5 snRNA

• Macromolecule: Name: U5 snRNA / type: rna / ID: 5 / Number of copies: 1
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 37.254855 KDa

Sequence

String:

AUACUCUGGU UUCUCUUCAG AUCGCAUAAA UCUUUCGCCU UUUACUAAAG AUUUCCGUGG AGAGGAACAA CUCUGAGUCU UAACCCAAU UUUUUGAGGC CUUGCUUUGG CAAGGCUA

GENBANK: GENBANK: AC105129.4

Macromolecule #6: U6atac snRNA

• Macromolecule: Name: U6atac snRNA / type: rna / ID: 6 / Number of copies: 1
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 40.39582 KDa

Sequence

String:

(G5J)UGUUGUAUG AAAGGAGAGA AGGUUAGCAC UCCCCUUGAC AAGGAUGGAA GAGGCCCUCG GGCCUGACAA CACGCA UAC GGUUAAGGCA UUGCCACCUA CUUCGUGGCA UCUAACCAUC GUUUUU

Macromolecule #4: Peptidylprolyl isomerase domain and WD repeat-containing protein 1

• Macromolecule: Name: Peptidylprolyl isomerase domain and WD repeat-containing protein 1; type: protein_or_peptide / ID: 4 / Number of copies: 1 / Enantiomer: LEVO / EC number: peptidylprolyl isomerase
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 73.679891 KDa

Sequence

String:

MAAESGSDFQ QRRRRRRDPE EPEKTELSER ELAVAVAVSQ ENDEENEERW VGPLPVEATL AKKRKVLEFE RVYLDNLPSA SMYERSYMH RDVITHVVCT KTDFIITASH DGHVKFWKKI EEGIEFVKHF RSHLGVIESI AVSSEGALFC SVGDDKAMKV F DVVNFDMI NMLKLGYFPG QCEWIYCPGD AISSVAASEK STGKIFIYDG RGDNQPLHIF DKLHTSPLTQ IRLNPVYKAV VS SDKSGMI EYWTGPPHEY KFPKNVNWEY KTDTDLYEFA KCKAYPTSVC FSPDGKKIAT IGSDRKVRIF RFVTGKLMRV FDE SLSMFT ELQQMRQQLP DMEFGRRMAV ERELEKVDAV RLINIVFDET GHFVLYGTML GIKVINVETN RCVRILGKQE NIRV MQLAL FQGIAKKHRA ATTIEMKASE NPVLQNIQAD PTIVCTSFKK NRFYMFTKRE PEDTKSADSD RDVFNEKPSK EEVMA ATQA EGPKRVSDSA IIHTSMGDIH TKLFPVECPK TVENFCVHSR NGYYNGHTFH RIIKGFMIQT GDPTGTGMGG ESIWGG EFE DEFHSTLRHD RPYTLSMANA GSNTNGSQFF ITVVPTPWLD NKHTVFGRVT KGMEVVQRIS NVKVNPKTDK PYEDVSI IN ITVK

UniProtKB: Peptidylprolyl isomerase domain and WD repeat-containing protein 1

Macromolecule #7: Pre-mRNA-processing-splicing factor 8

• Macromolecule: Name: Pre-mRNA-processing-splicing factor 8 / type: protein_or_peptide / ID: 7 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 273.97425 KDa

Sequence

String:

MAGVFPYRGP GNPVPGPLAP LPDYMSEEKL QEKARKWQQL QAKRYAEKRK FGFVDAQKED MPPEHVRKII RDHGDMTNRK FRHDKRVYL GALKYMPHAV LKLLENMPMP WEQIRDVPVL YHITGAISFV NEIPWVIEPV YISQWGSMWI MMRREKRDRR H FKRMRFPP FDDEEPPLDY ADNILDVEPL EAIQLELDPE EDAPVLDWFY DHQPLRDSRK YVNGSTYQRW QFTLPMMSTL YR LANQLLT DLVDDNYFYL FDLKAFFTSK ALNMAIPGGP KFEPLVRDIN LQDEDWNEFN DINKIIIRQP IRTEYKIAFP YLY NNLPHH VHLTWYHTPN VVFIKTEDPD LPAFYFDPLI NPISHRHSVK SQEPLPDDDE EFELPEFVEP FLKDTPLYTD NTAN GIALL WAPRPFNLRS GRTRRALDIP LVKNWYREHC PAGQPVKVRV SYQKLLKYYV LNALKHRPPK AQKKRYLFRS FKATK FFQS TKLDWVEVGL QVCRQGYNML NLLIHRKNLN YLHLDYNFNL KPVKTLTTKE RKKSRFGNAF HLCREVLRLT KLVVDS HVQ YRLGNVDAFQ LADGLQYIFA HVGQLTGMYR YKYKLMRQIR MCKDLKHLIY YRFNTGPVGK GPGCGFWAAG WRVWLFF MR GITPLLERWL GNLLARQFEG RHSKGVAKTV TKQRVESHFD LELRAAVMHD ILDMMPEGIK QNKARTILQH LSEAWRCW K ANIPWKVPGL PTPIENMILR YVKAKADWWT NTAHYNRERI RRGATVDKTV CKKNLGRLTR LYLKAEQERQ HNYLKDGPY ITAEEAVAVY TTTVHWLESR RFSPIPFPPL SYKHDTKLLI LALERLKEAY SVKSRLNQSQ REELGLIEQA YDNPHEALSR IKRHLLTQR AFKEVGIEFM DLYSHLVPVY DVEPLEKITD AYLDQYLWYE ADKRRLFPPW IKPADTEPPP LLVYKWCQGI N NLQDVWET SEGECNVMLE SRFEKMYEKI DLTLLNRLLR LIVDHNIADY MTAKNNVVIN YKDMNHTNSY GIIRGLQFAS FI VQYYGLV MDLLVLGLHR ASEMAGPPQM PNDFLSFQDI ATEAAHPIRL FCRYIDRIHI FFRFTADEAR DLIQRYLTEH PDP NNENIV GYNNKKCWPR DARMRLMKHD VNLGRAVFWD IKNRLPRSVT TVQWENSFVS VYSKDNPNLL FNMCGFECRI LPKC RTSYE EFTHKDGVWN LQNEVTKERT AQCFLRVDDE SMQRFHNRVR QILMASGSTT FTKIVNKWNT ALIGLMTYFR EAVVN TQEL LDLLVKCENK IQTRIKIGLN SKMPSRFPPV VFYTPKELGG LGMLSMGHVL IPQSDLRWSK QTDVGITHFR SGMSHE EDQ LIPNLYRYIQ PWESEFIDSQ RVWAEYALKR QEAIAQNRRL TLEDLEDSWD RGIPRINTLF QKDRHTLAYD KGWRVRT DF KQYQVLKQNP FWWTHQRHDG KLWNLNNYRT DMIQALGGVE GILEHTLFKG TYFPTWEGLF WEKASGFEES MKWKKLTN A QRSGLNQIPN RRFTLWWSPT INRANVYVGF QVQLDLTGIF MHGKIPTLKI SLIQIFRAHL WQKIHESIVM DLCQVFDQE LDALEIETVQ KETIHPRKSY KMNSSCADIL LFASYKWNVS RPSLLADSKD VMDSTTTQKY WIDIQLRWGD YDSHDIERYA RAKFLDYTT DNMSIYPSPT GVLIAIDLAY NLHSAYGNWF PGSKPLIQQA MAKIMKANPA LYVLRERIRK GLQLYSSEPT E PYLSSQNY GELFSNQIIW FVDDTNVYRV TIHKTFEGNL TTKPINGAIF IFNPRTGQLF LKIIHTSVWA GQKRLGQLAK WK TAEEVAA LIRSLPVEEQ PKQIIVTRKG MLDPLEVHLL DFPNIVIKGS ELQLPFQACL KVEKFGDLIL KATEPQMVLF NLY DDWLKT ISSYTAFSRL ILILRALHVN NDRAKVILKP DKTTITEPHH IWPTLTDEEW IKVEVQLKDL ILADYGKKNN VNVA SLTQS EIRDIILGME ISAPSQQRQQ IAEIEKQTKE QSQLTATQTR TVNKHGDEII TSTTSNYETQ TFSSKTEWRV RAISA ANLH LRTNHIYVSS DDIKETGYTY ILPKNVLKKF ICISDLRAQI AGYLYGVSPP DNPQVKEIRC IVMVPQWGTH QTVHLP GQL PQHEYLKEME PLGWIHTQPN ESPQLSPQDV TTHAKIMADN PSWDGEKTII ITCSFTPGSC TLTAYKLTPS GYEWGRQ NT DKGNNPKGYL PSHYERVQML LSDRFLGFFM VPAQSSWNYN FMGVRHDPNM KYELQLANPK EFYHEVHRPS HFLNFALL Q EGEVYSADRE DLYA

UniProtKB: Pre-mRNA-processing-splicing factor 8

Macromolecule #8: 116 kDa U5 small nuclear ribonucleoprotein component

• Macromolecule: Name: 116 kDa U5 small nuclear ribonucleoprotein component / type: protein_or_peptide / ID: 8 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 109.560625 KDa

Sequence

String:

MDTDLYDEFG NYIGPELDSD EDDDELGRET KDLDEMDDDD DDDDVGDHDD DHPGMEVVLH EDKKYYPTAE EVYGPEVETI VQEEDTQPL TEPIIKPVKT KKFTLMEQTL PVTVYEMDFL ADLMDNSELI RNVTLCGHLH HGKTCFVDCL IEQTHPEIRK R YDQDLCYT DILFTEQERG VGIKSTPVTV VLPDTKGKSY LFNIMDTPGH VNFSDEVTAG LRISDGVVLF IDAAEGVMLN TE RLIKHAV QERLAVTVCI NKIDRLILEL KLPPTDAYYK LRHIVDEVNG LISMYSTDEN LILSPLLGNV CFSSSQYSIC FTL GSFAKI YADTFGDINY QEFAKRLWGD IYFNPKTRKF TKKAPTSSSQ RSFVEFILEP LYKILAQVVG DVDTSLPRTL DELG IHLTK EELKLNIRPL LRLVCKKFFG EFTGFVDMCV QHIPSPKVGA KPKIEHTYTG GVDSDLGEAM SDCDPDGPLM CHTTK MYST DDGVQFHAFG RVLSGTIHAG QPVKVLGENY TLEDEEDSQI CTVGRLWISV ARYHIEVNRV PAGNWVLIEG VDQPIV KTA TITEPRGNEE AQIFRPLKFN TTSVIKIAVE PVNPSELPKM LDGLRKVNKS YPSLTTKVEE SGEHVILGTG ELYLDCV MH DLRKMYSEID IKVADPVVTF CETVVETSSL KCFAETPNKK NKITMIAEPL EKGLAEDIEN EVVQITWNRK KLGEFFQT K YDWDLLAARS IWAFGPDATG PNILVDDTLP SEVDKALLGS VKDSIVQGFQ WGTREGPLCD ELIRNVKFKI LDAVVAQEP LHRGGGQIIP TARRVVYSAF LMATPRLMEP YYFVEVQAPA DCVSAVYTVL ARRRGHVTQD APIPGSPLYT IKAFIPAIDS FGFETDLRT HTQGQAFSLS VFHHWQIVPG DPLDKSIVIR PLEPQPAPHL AREFMIKTRR RKGLSEDVSI SKFFDDPMLL E LAKQDVVL NYPM

UniProtKB: 116 kDa U5 small nuclear ribonucleoprotein component

Macromolecule #9: U5 small nuclear ribonucleoprotein 200 kDa helicase

• Macromolecule: Name: U5 small nuclear ribonucleoprotein 200 kDa helicase / type: protein_or_peptide / ID: 9 / Number of copies: 1 / Enantiomer: LEVO / EC number: RNA helicase
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 244.823422 KDa

Sequence

String:

MADVTARSLQ YEYKANSNLV LQADRSLIDR TRRDEPTGEV LSLVGKLEGT RMGDKAQRTK PQMQEERRAK RRKRDEDRHD INKMKGYTL LSEGIDEMVG IIYKPKTKET RETYEVLLSF IQAALGDQPR DILCGAADEV LAVLKNEKLR DKERRKEIDL L LGQTDDTR YHVLVNLGKK ITDYGGDKEI QNMDDNIDET YGVNVQFESD EEEGDEDVYG EVREEASDDD MEGDEAVVRC TL SANLVAS GELMSSKKKD LHPRDIDAFW LQRQLSRFYD DAIVSQKKAD EVLEILKTAS DDRECENQLV LLLGFNTFDF IKV LRQHRM MILYCTLLAS AQSEAEKERI MGKMEADPEL SKFLYQLHET EKEDLIREER SRRERVRQSR MDTDLETMDL DQGG EALAP RQVLDLEDLV FTQGSHFMAN KRCQLPDGSF RRQRKGYEEV HVPALKPKPF GSEEQLLPVE KLPKYAQAGF EGFKT LNRI QSKLYRAALE TDENLLLCAP TGAGKTNVAL MCMLREIGKH INMDGTINVD DFKIIYIAPM RSLVQEMVGS FGKRLA TYG ITVAELTGDH QLCKEEISAT QIIVCTPEKW DIITRKGGER TYTQLVRLII LDEIHLLHDD RGPVLEALVA RAIRNIE MT QEDVRLIGLS ATLPNYEDVA TFLRVDPAKG LFYFDNSFRP VPLEQTYVGI TEKKAIKRFQ IMNEIVYEKI MEHAGKNQ V LVFVHSRKET GKTARAIRDM CLEKDTLGLF LREGSASTEV LRTEAEQCKN LELKDLLPYG FAIHHAGMTR VDRTLVEDL FADKHIQVLV STATLAWGVN LPAHTVIIKG TQVYSPEKGR WTELGALDIL QMLGRAGRPQ YDTKGEGILI TSHGELQYYL SLLNQQLPI ESQMVSKLPD MLNAEIVLGN VQNAKDAVNW LGYAYLYIRM LRSPTLYGIS HDDLKGDPLL DQRRLDLVHT A ALMLDKNN LVKYDKKTGN FQVTELGRIA SHYYITNDTV QTYNQLLKPT LSEIELFRVF SLSSEFKNIT VREEEKLELQ KL LERVPIP VKESIEEPSA KINVLLQAFI SQLKLEGFAL MADMVYVTQS AGRLMRAIFE IVLNRGWAQL TDKTLNLCKM IDK RMWQSM CPLRQFRKLP EEVVKKIEKK NFPFERLYDL NHNEIGELIR MPKMGKTIHK YVHLFPKLEL SVHLQPITRS TLKV ELTIT PDFQWDEKVH GSSEAFWILV EDVDSEVILH HEYFLLKAKY AQDEHLITFF VPVFEPLPPQ YFIRVVSDRW LSCET QLPV SFRHLILPEK YPPPTELLDL QPLPVSALRN SAFESLYQDK FPFFNPIQTQ VFNTVYNSDD NVFVGAPTGS GKTICA EFA ILRMLLQSSE GRCVYITPME ALAEQVYMDW YEKFQDRLNK KVVLLTGETS TDLKLLGKGN IIISTPEKWD ILSRRWK QR KNVQNINLFV VDEVHLIGGE NGPVLEVICS RMRYISSQIE RPIRIVALSS SLSNAKDVAH WLGCSATSTF NFHPNVRP V PLELHIQGFN ISHTQTRLLS MAKPVYHAIT KHSPKKPVIV FVPSRKQTRL TAIDILTTCA ADIQRQRFLH CTEKDLIPY LEKLSDSTLK ETLLNGVGYL HEGLSPMERR LVEQLFSSGA IQVVVASRSL CWGMNVAAHL VIIMDTQYYN GKIHAYVDYP IYDVLQMVG HANRPLQDDE GRCVIMCQGS KKDFFKKFLY EPLPVESHLD HCMHDHFNAE IVTKTIENKQ DAVDYLTWTF L YRRMTQNP NYYNLQGISH RHLSDHLSEL VEQTLSDLEQ SKCISIEDEM DVAPLNLGMI AAYYYINYTT IELFSMSLNA KT KVRGLIE IISNAAEYEN IPIRHHEDNL LRQLAQKVPH KLNNPKFNDP HVKTNLLLQA HLSRMQLSAE LQSDTEEILS KAI RLIQAC VDVLSSNGWL SPALAAMELA QMVTQAMWSK DSYLKQLPHF TSEHIKRCTD KGVESVFDIM EMEDEERNAL LQLT DSQIA DVARFCNRYP NIELSYEVVD KDSIRSGGPV VVLVQLEREE EVTGPVIAPL FPQKREEGWW VVIGDAKSNS LISIK RLTL QQKAKVKLDF VAPATGAHNY TLYFMSDAYM GCDQEYKFSV DVKEAETDSD SD

UniProtKB: U5 small nuclear ribonucleoprotein 200 kDa helicase

Macromolecule #10: U5 small nuclear ribonucleoprotein 40 kDa protein

• Macromolecule: Name: U5 small nuclear ribonucleoprotein 40 kDa protein / type: protein_or_peptide / ID: 10 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 39.359492 KDa

Sequence

String:

MIEQQKRKGP ELPLVPVKRQ RHELLLGAGS GPGAGQQQAT PGALLQAGPP RCSSLQAPIM LLSGHEGEVY CCKFHPNGST LASAGFDRL ILLWNVYGDC DNYATLKGHS GAVMELHYNT DGSMLFSAST DKTVAVWDSE TGERVKRLKG HTSFVNSCYP A RRGPQLVC TGSDDGTVKL WDIRKKAAIQ TFQNTYQVLA VTFNDTSDQI ISGGIDNDIK VWDLRQNKLT YTMRGHADSV TG LSLSSEG SYLLSNAMDN TVRVWDVRPF APKERCVKIF QGNVHNFEKN LLRCSWSPDG SKIAAGSADR FVYVWDTTSR RIL YKLPGH AGSINEVAFH PDEPIIISAS SDKRLYMGEI Q

UniProtKB: U5 small nuclear ribonucleoprotein 40 kDa protein

Macromolecule #11: Cell division cycle 5-like protein

• Macromolecule: Name: Cell division cycle 5-like protein / type: protein_or_peptide / ID: 11 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 92.406883 KDa

Sequence

String:

MPRIMIKGGV WRNTEDEILK AAVMKYGKNQ WSRIASLLHR KSAKQCKARW YEWLDPSIKK TEWSREEEEK LLHLAKLMPT QWRTIAPII GRTAAQCLEH YEFLLDKAAQ RDNEEETTDD PRKLKPGEID PNPETKPARP DPIDMDEDEL EMLSEARARL A NTQGKKAK RKAREKQLEE ARRLAALQKR RELRAAGIEI QKKRKRKRGV DYNAEIPFEK KPALGFYDTS EENYQALDAD FR KLRQQDL DGELRSEKEG RDRKKDKQHL KRKKESDLPS AILQTSGVSE FTKKRSKLVL PAPQISDAEL QEVVKVGQAS EIA RQTAEE SGITNSASST LLSEYNVTNN SVALRTPRTP ASQDRILQEA QNLMALTNVD TPLKGGLNTP LHESDFSGVT PQRQ VVQTP NTVLSTPFRT PSNGAEGLTP RSGTTPKPVI NSTPGRTPLR DKLNINPEDG MADYSDPSYV KQMERESREH LRLGL LGLP APKNDFEIVL PENAEKELEE REIDDTYIED AADVDARKQA IRDAERVKEM KRMHKAVQKD LPRPSEVNET ILRPLN VEP PLTDLQKSEE LIKKEMITML HYDLLHHPYE PSGNKKGKTV GFGTNNSEHI TYLEHNPYEK FSKEELKKAQ DVLVQEM EV VKQGMSHGEL SSEAYNQVWE ECYSQVLYLP GQSRYTRANL ASKKDRIESL EKRLEINRGH MTTEAKRAAK MEKKMKIL L GGYQSRAMGL MKQLNDLWDQ IEQAHLELRT FEELKKHEDS AIPRRLECLK EDVQRQQERE KELQHRYADL LLEKETLKS KF

UniProtKB: Cell division cycle 5-like protein

Macromolecule #12: Pre-mRNA-splicing factor SYF1

• Macromolecule: Name: Pre-mRNA-splicing factor SYF1 / type: protein_or_peptide / ID: 12 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 100.148711 KDa

Sequence

String:

MVVMARLSRP ERPDLVFEEE DLPYEEEIMR NQFSVKCWLR YIEFKQGAPK PRLNQLYERA LKLLPCSYKL WYRYLKARRA QVKHRCVTD PAYEDVNNCH ERAFVFMHKM PRLWLDYCQF LMDQGRVTHT RRTFDRALRA LPITQHSRIW PLYLRFLRSH P LPETAVRG YRRFLKLSPE SAEEYIEYLK SSDRLDEAAQ RLATVVNDER FVSKAGKSNY QLWHELCDLI SQNPDKVQSL NV DAIIRGG LTRFTDQLGK LWCSLADYYI RSGHFEKARD VYEEAIRTVM TVRDFTQVFD SYAQFEESMI AAKMETASEL GRE EEDDVD LELRLARFEQ LISRRPLLLN SVLLRQNPHH VHEWHKRVAL HQGRPREIIN TYTEAVQTVD PFKATGKPHT LWVA FAKFY EDNGQLDDAR VILEKATKVN FKQVDDLASV WCQCGELELR HENYDEALRL LRKATALPAR RAEYFDGSEP VQNRV YKSL KVWSMLADLE ESLGTFQSTK AVYDRILDLR IATPQIVINY AMFLEEHKYF EESFKAYERG ISLFKWPNVS DIWSTY LTK FIARYGGRKL ERARDLFEQA LDGCPPKYAK TLYLLYAQLE EEWGLARHAM AVYERATRAV EPAQQYDMFN IYIKRAA EI YGVTHTRGIY QKAIEVLSDE HAREMCLRFA DMECKLGEID RARAIYSFCS QICDPRTTGA FWQTWKDFEV RHGNEDTI K EMLRIRRSVQ ATYNTQVNFM ASQMLKVSGS ATGTVSDLAP GQSGMDDMKL LEQRAEQLAA EAERDQPLRA QSKILFVRS DASREELAEL AQQVNPEEIQ LGEDEDEDEM DLEPNEVRLE QQSVPAAVFG SLKED

UniProtKB: Pre-mRNA-splicing factor SYF1

Macromolecule #13: Crooked neck-like protein 1

• Macromolecule: Name: Crooked neck-like protein 1 / type: protein_or_peptide / ID: 13 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 100.610008 KDa

Sequence

String:

MTATVENLTF QKDTLGNAVD KNTSRLELRS YSLAGRHGST EPLVLAWSSQ FRRLTWGCAL DALHRSPCVA ASQHGVTHLI RSSRTPHST RCRKEDAQPG HHGNGAASVT AQARGQRSVL QVPLPVPRSC LFSESFVVSV SSQSRFLASV PGTGVQRSTA A DMAASTAA GKQRIPKVAK VKNKAPAEVQ ITAEQLLREA KERELELLPP PPQQKITDEE ELNDYKLRKR KTFEDNIRKN RT VISNWIK YAQWEESLKE IQRARSIYER ALDVDYRNIT LWLKYAEMEM KNRQVNHARN IWDRAITTLP RVNQFWYKYT YME EMLGNV AGARQVFERW MEWQPEEQAW HSYINFELRY KEVDRARTIY ERFVLVHPDV KNWIKYARFE EKHAYFAHAR KVYE RAVEF FGDEHMDEHL YVAFAKFEEN QKEFERVRVI YKYALDRISK QDAQELFKNY TIFEKKFGDR RGIEDIIVSK RRFQY EEEV KANPHNYDAW FDYLRLVESD AEAEAVREVY ERAIANVPPI QEKRHWKRYI YLWINYALYE ELEAKDPERT RQVYQA SLE LIPHKKFTFA KMWILYAQFE IRQKNLSLAR RALGTSIGKC PKNKLFKVYI ELELQLREFD RCRKLYEKFL EFGPENC TS WIKFAELETI LGDIDRARAI YELAISQPRL DMPEVLWKSY IDFEIEQEET ERTRNLYRRL LQRTQHVKVW ISFAQFEL S SGKEGSLTKC RQIYEEANKT MRNCEEKEER LMLLESWRSF EEEFGTASDK ERVDKLMPEK VKKRRKVQTD DGSDAGWEE YFDYIFPEDA ANQPNLKLLA MAKLWKKQQQ EKEDAEHHPD EDVDESES

UniProtKB: Crooked neck-like protein 1

Macromolecule #14: Coiled-coil domain-containing protein 12

• Macromolecule: Name: Coiled-coil domain-containing protein 12 / type: protein_or_peptide / ID: 14 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 19.22385 KDa

Sequence

String:

MEATTAGVGR LEEEALRRKE RLKALREKTG RKDKEDGEPK TKHLREEEEE GEKHRELRLR NYVPEDEDLK KRRVPQAKPV AVEEKVKEQ LEAAKPEPVI EEVDLANLAP RKPDWDLKRD VAKKLEKLKK RTQRAIAELI RERLKGQEDS LASAVDAATE Q KTCDSD

UniProtKB: Coiled-coil domain-containing protein 12

Macromolecule #15: Pre-mRNA-splicing factor ISY1 homolog

• Macromolecule: Name: Pre-mRNA-splicing factor ISY1 homolog / type: protein_or_peptide / ID: 15 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 33.046254 KDa

Sequence

String:

MARNAEKAMT ALARFRQAQL EEGKVKERRP FLASECTELP KAEKWRRQII GEISKKVAQI QNAGLGEFRI RDLNDEINKL LREKGHWEV RIKELGGPDY GKVGPKMLDH EGKEVPGNRG YKYFGAAKDL PGVRELFEKE PLPPPRKTRA ELMKAIDFEY Y GYLDEDDG VIVPLEQEYE KKLRAELVEK WKAEREARLA RGEKEEEEEE EEEINIYAVT EEESDEEGSQ EKGGDDSQQK FI AHVPVPS QQEIEEALVR RKKMELLQKY ASETLQAQSE EARRLLGY

UniProtKB: Pre-mRNA-splicing factor ISY1 homolog

Macromolecule #16: SNW domain-containing protein 1

• Macromolecule: Name: SNW domain-containing protein 1 / type: protein_or_peptide / ID: 16 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 61.770648 KDa

Sequence

String:

MALTSFLPAP TQLSQDQLEA EEKARSQRSR QTSLVSSRRE PPPYGYRKGW IPRLLEDFGD GGAFPEIHVA QYPLDMGRKK KMSNALAIQ VDSEGKIKYD AIARQGQSKD KVIYSKYTDL VPKEVMNADD PDLQRPDEEA IKEITEKTRV ALEKSVSQKV A AAMPVRAA DKLAPAQYIR YTPSQQGVAF NSGAKQRVIR MVEMQKDPME PPRFKINKKI PRGPP(SEP)PPAP VMH(SEP) PSRKM TVKEQQEWKI PPCISNWKNA KGYTIPLDKR LAADGRGLQT VHINENFAKL AEALYIADRK AREAVEMRAQ VERKM AQKE KEKHEEKLRE MAQKARERRA GIKTHVEKED GEARERDEIR HDRRKERQHD RNLSRAAPDK RSKLQRNENR DISEVI ALG VPNPRTSNEV QYDQRLFNQS KGMDSGFAGG EDEIYNVYDQ AWRGGKDMAQ SIYRPSKNLD KDMYGDDLEA RIKTNRF VP DKEFSGSDRR QRGREGPVQF EEDPFGLDKF LEEAKQHGGS KRPSDSSRPK EHEHEGKKRR KE

UniProtKB: SNW domain-containing protein 1

Macromolecule #17: Pleiotropic regulator 1

• Macromolecule: Name: Pleiotropic regulator 1 / type: protein_or_peptide / ID: 17 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 57.280758 KDa

Sequence

String:

MVEEVQKHSV HTLVFRSLKR THDMFVADNG KPVPLDEESH KRKMAIKLRN EYGPVLHMPT SKENLKEKGP QNATDSYVHK QYPANQGQE VEYFVAGTHP YPPGPGVALT ADTKIQRMPS ESAAQSLAVA LPLQTKADAN RTAPSGSEYR HPGASDRPQP T AMNSIVME TGNTKNSALM AKKAPTMPKP QWHPPWKLYR VISGHLGWVR CIAVEPGNQW FVTGSADRTI KIWDLASGKL KL SLTGHIS TVRGVIVSTR SPYLFSCGED KQVKCWDLEY NKVIRHYHGH LSAVYGLDLH PTIDVLVTCS RDSTARIWDV RTK ASVHTL SGHTNAVATV RCQAAEPQII TGSHDTTIRL WDLVAGKTRV TLTNHKKSVR AVVLHPRHYT FASGSPDNIK QWKF PDGSF IQNLSGHNAI INTLTVNSDG VLVSGADNGT MHLWDWRTGY NFQRVHAAVQ PGSLDSESGI FACAFDQSES RLLTA EADK TIKVYREDDT ATEETHPVSW KPEIIKRKRF

UniProtKB: Pleiotropic regulator 1

Macromolecule #18: RNA-binding protein 48

• Macromolecule: Name: RNA-binding protein 48 / type: protein_or_peptide / ID: 18 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 41.878523 KDa

Sequence

String:

MASSGGELGS LFDHHVQRAV CDTRAKYREG RRPRAVKVYT INLESQYLLI QGVPAVGVMK ELVERFALYG AIEQYNALDE YPAEDFTEV YLIKFMNLQS ARTAKRKMDE QSFFGGLLHV CYAPEFETVE ETRKKLQMRK AYVVKTTENK DHYVTKKKLV T EHKDTEDF RQDFHSEMSG FCKAALNTSA GNSNPYLPYS CELPLCYFSS KCMCSSGGPV DRAPDSSKDG RNHHKTMGHY NH NDSLRKT QINSLKNSVA CPGAQKAITS SEAVDRFMPR TTQLQERKRR REDDRKLGTF LQTNPTGNEI MIGPLLPDIS KVD MHDDSL NTTANLIRHK LKEVISSVPK PPEDKPEDVH TSHPLKQRRR I

UniProtKB: RNA-binding protein 48

Macromolecule #19: U6 snRNA-associated Sm-like protein LSm2

• Macromolecule: Name: U6 snRNA-associated Sm-like protein LSm2 / type: protein_or_peptide / ID: 19 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 10.847495 KDa

Sequence

String:

MLFYSFFKSL VGKDVVVELK NDLSICGTLH SVDQYLNIKL TDISVTDPEK YPHMLSVKNC FIRGSVVRYV QLPADEVDTQ LLQDAARKE ALQQKQ

UniProtKB: U6 snRNA-associated Sm-like protein LSm2

Macromolecule #20: U6 snRNA-associated Sm-like protein LSm3

• Macromolecule: Name: U6 snRNA-associated Sm-like protein LSm3 / type: protein_or_peptide / ID: 20 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 11.85939 KDa

Sequence

String:

MADDVDQQQT TNTVEEPLDL IRLSLDERIY VKMRNDRELR GRLHAYDQHL NMILGDVEET VTTIEIDEET YEEIYKSTKR NIPMLFVRG DGVVLVAPPL RVG

UniProtKB: U6 snRNA-associated Sm-like protein LSm3

Macromolecule #21: U6 snRNA-associated Sm-like protein LSm4

• Macromolecule: Name: U6 snRNA-associated Sm-like protein LSm4 / type: protein_or_peptide / ID: 21 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 15.375775 KDa

Sequence

String:

MLPLSLLKTA QNHPMLVELK NGETYNGHLV SCDNWMNINL REVICTSRDG DKFWRMPECY IRGSTIKYLR IPDEIIDMVK EEVVAKGRG RGGLQQQKQQ KGRGMGGAGR GVFGGRGRGG IPGTGRGQPE KKPGRQAGKQ

UniProtKB: U6 snRNA-associated Sm-like protein LSm4

Macromolecule #22: U6 snRNA-associated Sm-like protein LSm5

• Macromolecule: Name: U6 snRNA-associated Sm-like protein LSm5 / type: protein_or_peptide / ID: 22 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 9.945448 KDa

Sequence

String:

MAANATTNPS QLLPLELVDK CIGSRIHIVM KSDKEIVGTL LGFDDFVNMV LEDVTEFEIT PEGRRITKLD QILLNGNNIT MLVPGGEGP EV

UniProtKB: U6 snRNA-associated Sm-like protein LSm5

Macromolecule #23: U6 snRNA-associated Sm-like protein LSm6

• Macromolecule: Name: U6 snRNA-associated Sm-like protein LSm6 / type: protein_or_peptide / ID: 23 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 9.139571 KDa

Sequence

String:

MSLRKQTPSD FLKQIIGRPV VVKLNSGVDY RGVLACLDGY MNIALEQTEE YVNGQLKNKY GDAFIRGNNV LYISTQKRRM

UniProtKB: U6 snRNA-associated Sm-like protein LSm6

Macromolecule #24: U6 snRNA-associated Sm-like protein LSm7

• Macromolecule: Name: U6 snRNA-associated Sm-like protein LSm7 / type: protein_or_peptide / ID: 24 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 11.617363 KDa

Sequence

String:

MADKEKKKKE SILDLSKYID KTIRVKFQGG REASGILKGF DPLLNLVLDG TIEYMRDPDD QYKLTEDTRQ LGLVVCRGTS VVLICPQDG MEAIPNPFIQ QQDA

UniProtKB: U6 snRNA-associated Sm-like protein LSm7

Macromolecule #25: U6 snRNA-associated Sm-like protein LSm8

• Macromolecule: Name: U6 snRNA-associated Sm-like protein LSm8 / type: protein_or_peptide / ID: 25 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 10.410589 KDa

Sequence

String:

MTSALENYIN RTVAVITSDG RMIVGTLKGF DQTINLILDE SHERVFSSSQ GVEQVVLGLY IVRGDNVAVI GEIDEETDSA LDLGNIRAE PLNSVAH

UniProtKB: U6 snRNA-associated Sm-like protein LSm8

Macromolecule #26: Armadillo repeat-containing protein 7

• Macromolecule: Name: Armadillo repeat-containing protein 7 / type: protein_or_peptide / ID: 26 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 21.946039 KDa

Sequence

String:

MAQKPKVDPH VGRLGYLQAL VTEFQETQSQ DAKEQVLANL ANFAYDPSNY EYLRQLQVLD LFLDSLSEEN ETLVEFAIGG LCNLCPDRA NKEHILHAGG VPLIINCLSS PNEETVLSAI TTLMHLSPPG RSFLPELTAT PVVQCMLRFS LSASARLRNL A QIFLEDFC SPRQVAEARS RQAHSALGIP LPRSVAPRQR

UniProtKB: Armadillo repeat-containing protein 7

Macromolecule #27: Spliceosome-associated protein CWC15 homolog

• Macromolecule: Name: Spliceosome-associated protein CWC15 homolog / type: protein_or_peptide / ID: 27 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 26.674447 KDa

Sequence

String:

MTTAARPTFE PARGGRGKGE GDLSQLSKQY SSRDLPSHTK IKYRQTTQDA PEEVRNRDFR RELEERERAA AREKNRDRPT REHTTSSSV SKKPRLDQIP AANLDADDPL TDEEDEDFEE ESDDDDTAAL LAELEKIKKE RAEEQARKEQ EQKAEEERIR M ENILSGNP LLNLTGPSQP QANFKVKRRW DDDVVFKNCA KGVDDQKKDK RFVNDTLRSE FHKKFMEKYI K

UniProtKB: Spliceosome-associated protein CWC15 homolog

Macromolecule #28: Peptidyl-prolyl cis-trans isomerase-like 1

• Macromolecule: Name: Peptidyl-prolyl cis-trans isomerase-like 1 / type: protein_or_peptide / ID: 28 / Number of copies: 1 / Enantiomer: LEVO / EC number: peptidylprolyl isomerase
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 18.257805 KDa

Sequence

String:

MAAIPPDSWQ PPNVYLETSM GIIVLELYWK HAPKTCKNFA ELARRGYYNG TKFHRIIKDF MIQGGDPTGT GRGGASIYGK QFEDELHPD LKFTGAGILA MANAGPDTNG SQFFVTLAPT QWLDGKHTIF GRVCQGIGMV NRVGMVETNS QDRPVDDVKI I KAYPSG

UniProtKB: Peptidyl-prolyl cis-trans isomerase-like 1

Macromolecule #29: Peptidyl-prolyl cis-trans isomerase E

• Macromolecule: Name: Peptidyl-prolyl cis-trans isomerase E / type: protein_or_peptide / ID: 29 / Number of copies: 1 / Enantiomer: LEVO / EC number: peptidylprolyl isomerase
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 33.475773 KDa

Sequence

String:

MATTKRVLYV GGLAEEVDDK VLHAAFIPFG DITDIQIPLD YETEKHRGFA FVEFELAEDA AAAIDNMNES ELFGRTIRVN LAKPMRIKE GSSRPVWSDD DWLKKFSGKT LEENKEEEGS EPPKAETQEG EPIAKKARSN PQVYMDIKIG NKPAGRIQML L RSDVVPMT AENFRCLCTH EKGFGFKGSS FHRIIPQFMC QGGDFTNHNG TGGKSIYGKK FDDENFILKH TGPGLLSMAN SG PNTNGSQ FFLTCDKTDW LDGKHVVFGE VTEGLDVLRQ IEAQGSKDGK PKQKVIIADC GEYV

UniProtKB: Peptidyl-prolyl cis-trans isomerase E

Macromolecule #30: RNA helicase aquarius

• Macromolecule: Name: RNA helicase aquarius / type: protein_or_peptide / ID: 30 / Number of copies: 1 / Enantiomer: LEVO / EC number: RNA helicase
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 171.502453 KDa

Sequence

String:

MAAPAQPKKI VAPTVSQINA EFVTQLACKY WAPHIKKKSP FDIKVIEDIY EKEIVKSRFA IRKIMLLEFS QYLENYLWMN YSPEVSSKA YLMSICCMVN EKFRENVPAW EIFKKKPDHF PFFFKHILKA ALAETDGEFS LHEQTVLLLF LDHCFNSLEV D LIRSQVQQ LISLPMWMGL QLARLELELK KTPKLRKFWN LIKKNDEKMD PEAREQAYQE RRFLSQLIQK FISVLKSVPL SE PVTMDKV HYCERFIELM IDLEALLPTR RWFNTILDDS HLLVHCYLSN LVRREEDGHL FSQLLDMLKF YTGFEINDQT GNA LTENEM TTIHYDRITS LQRAAFAHFP ELYDFALSNV AEVDTRESLV KFFGPLSSNT LHQVASYLCL LPTLPKNEDT TFDK EFLLE LLVSRHERRI SQIQQLNQMP LYPTEKIIWD ENIVPTEYYS GEGCLALPKL NLQFLTLHDY LLRNFNLFRL ESTYE IRQD IEDSVSRMKP WQSEYGGVVF GGWARMAQPI VAFTVVEVAK PNIGENWPTR VRADVTINLN VRDHIKDEWE GLRKHD VCF LITVRPTKPY GTKFDRRRPF IEQVGLVYVR GCEIQGMLDD KGRVIEDGPE PRPNLRGESR TFRVFLDPNQ YQQDMTN TI QNGAEDVYET FNIIMRRKPK ENNFKAVLET IRNLMNTDCV VPDWLHDIIL GYGDPSSAHY SKMPNQIATL DFNDTFLS I EHLKASFPGH NVKVTVEDPA LQIPPFRITF PVRSGKGKKR KDADVEDEDT EEAKTLIVEP HVIPNRGPYP YNQPKRNTI QFTHTQIEAI RAGMQPGLTM VVGPPGTGKT DVAVQIISNI YHNFPEQRTL IVTHSNQALN QLFEKIMALD IDERHLLRLG HGEEELETE KDFSRYGRVN YVLARRIELL EEVKRLQKSL GVPGDASYTC ETAGYFFLYQ VMSRWEEYIS KVKNKGSTLP D VTEVSTFF PFHEYFANAP QPIFKGRSYE EDMEIAEGCF RHIKKIFTQL EEFRASELLR SGLDRSKYLL VKEAKIIAMT CT HAALKRH DLVKLGFKYD NILMEEAAQI LEIETFIPLL LQNPQDGFSR LKRWIMIGDH HQLPPVIKNM AFQKYSNMEQ SLF TRFVRV GVPTVDLDAQ GRARASLCNL YNWRYKNLGN LPHVQLLPEF STANAGLLYD FQLINVEDFQ GVGESEPNPY FYQN LGEAE YVVALFMYMC LLGYPADKIS ILTTYNGQKH LIRDIINRRC GNNPLIGRPN KVTTVDRFQG QQNDYILLSL VRTRA VGHL RDVRRLVVAM SRARLGLYIF ARVSLFQNCF ELTPAFSQLT ARPLHLHIIP TEPFPTTRKN GERPSHEVQI IKNMPQ MAN FVYNMYMHLI QTTHHYHQTL LQLPPAMVEE GEEVQNQETE LETEEEAMTV QADIIPSPTD TSCRQETPAF QTDTTPS ET GATSTPEAIP ALSETTPTVV GAVSAPAEAN TPQDATSAPE ETK

UniProtKB: RNA helicase aquarius

Macromolecule #31: Peptidyl-prolyl cis-trans isomerase-like 3

• Macromolecule: Name: Peptidyl-prolyl cis-trans isomerase-like 3 / type: protein_or_peptide / ID: 31 / Number of copies: 1 / Enantiomer: LEVO / EC number: peptidylprolyl isomerase
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 18.177547 KDa

Sequence

String:

MSVTLHTDVG DIKIEVFCER TPKTCENFLA LCASNYYNGC IFHRNIKGFM VQTGDPTGTG RGGNSIWGKK FEDEYSEYLK HNVRGVVSM ANNGPNTNGS QFFITYGKQP HLDMKYTVFG KVIDGLETLD ELEKLPVNEK TYRPLNDVHI KDITIHANPF A Q

UniProtKB: Peptidyl-prolyl cis-trans isomerase-like 3

Macromolecule #32: Pre-mRNA-splicing factor SLU7

• Macromolecule: Name: Pre-mRNA-splicing factor SLU7 / type: protein_or_peptide / ID: 32 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 68.510844 KDa

Sequence

String:

MSATVVDAVN AAPLSGSKEM SLEEPKKMTR EDWRKKKELE EQRKLGNAPA EVDEEGKDIN PHIPQYISSV PWYIDPSKRP TLKHQRPQP EKQKQFSSSG EWYKRGVKEN SIITKYRKGA CENCGAMTHK KKDCFERPRR VGAKFTGTNI APDEHVQPQL M FDYDGKRD RWNGYNPEEH MKIVEEYAKV DLAKRTLKAQ KLQEELASGK LVEQANSPKH QWGEEEPNSQ MEKDHNSEDE DE DKYADDI DMPGQNFDSK RRITVRNLRI REDIAKYLRN LDPNSAYYDP KTRAMRENPY ANAGKNPDEV SYAGDNFVRY TGD TISMAQ TQLFAWEAYD KGSEVHLQAD PTKLELLYKS FKVKKEDFKE QQKESILEKY GGQEHLDAPP AELLLAQTED YVEY SRHGT VIKGQERAVA CSKYEEDVKI HNHTHIWGSY WKEGRWGYKC CHSFFKYSYC TGEAGKEIVN SEECIINEIT GEESV KKPQ TLMELHQEKL KEEKKKKKKK KKKHRKSSSD SDDEEKKHEK LKKALNAEEA RLLHVKETMQ IDERKRPYNS MYETRE PTE EEMEAYRMKR QRPDDPMASF LGQ

UniProtKB: Pre-mRNA-splicing factor SLU7

Macromolecule #33: ATP-dependent RNA helicase DHX8

• Macromolecule: Name: ATP-dependent RNA helicase DHX8 / type: protein_or_peptide / ID: 33 / Number of copies: 1 / Enantiomer: LEVO / EC number: RNA helicase
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 139.522312 KDa

Sequence

String:

MAVAVAMAGA LIGSEPGPAE ELAKLEYLSL VSKVCTELDN HLGINDKDLA EFVISLAEKN TTFDTFKASL VKNGAEFTDS LISNLLRLI QTMRPPAKPS TSKDPVVKPK TEKEKLKELF PVLCQPDNPS VRTMLDEDDV KVAVDVLKEL EALMPSAAGQ E KQRDAEHR DRTKKKKRSR SRDRNRDRDR DRERNRDRDH KRRHRSRSRS RSRTRERNKV KSRYRSRSRS QSPPKDRKDR DK YGERNLD RWRDKHVDRP PPEEPTIGDI YNGKVTSIMQ FGCFVQLEGL RKRWEGLVHI SELRREGRVA NVADVVSKGQ RVK VKVLSF TGTKTSLSMK DVDQETGEDL NPNRRRNLVG ETNEETSMRN PDRPTHLSLV SAPEVEDDSL ERKRLTRISD PEKW EIKQM IAANVLSKEE FPDFDEETGI LPKVDDEEDE DLEIELVEEE PPFLRGHTKQ SMDMSPIKIV KNPDGSLSQA AMMQS ALAK ERRELKQAQR EAEMDSIPMG LNKHWVDPLP DAEGRQIAAN MRGIGMMPND IPEWKKHAFG GNKASYGKKT QMSILE QRE SLPIYKLKEQ LVQAVHDNQI LIVIGETGSG KTTQITQYLA EAGYTSRGKI GCTQPRRVAA MSVAKRVSEE FGCCLGQ EV GYTIRFEDCT SPETVIKYMT DGMLLRECLI DPDLTQYAII MLDEAHERTI HTDVLFGLLK KTVQKRQDMK LIVTSATL D AVKFSQYFYE APIFTIPGRT YPVEILYTKE PETDYLDASL ITVMQIHLTE PPGDILVFLT GQEEIDTACE ILYERMKSL GPDVPELIIL PVYSALPSEM QTRIFDPAPP GSRKVVIATN IAETSLTIDG IYYVVDPGFV KQKVYNSKTG IDQLVVTPIS QAQAKQRAG RAGRTGPGKC YRLYTERAYR DEMLTTNVPE IQRTNLASTV LSLKAMGIND LLSFDFMDAP PMETLITAME Q LYTLGALD DEGLLTRLGR RMAEFPLEPM LCKMLIMSVH LGCSEEMLTI VSMLSVQNVF YRPKDKQALA DQKKAKFHQT EG DHLTLLA VYNSWKNNKF SNPWCYENFI QARSLRRAQD IRKQMLGIMD RHKLDVVSCG KSTVRVQKAI CSGFFRNAAK KDP QEGYRT LIDQQVVYIH PSSALFNRQP EWVVYHELVL TTKEYMREVT TIDPRWLVEF APAFFKVSDP TKLSKQKKQQ RLEP LYNRY EEPNAWRISR AFRRR

UniProtKB: ATP-dependent RNA helicase DHX8

Macromolecule #34: Serine/arginine repetitive matrix protein 2

• Macromolecule: Name: Serine/arginine repetitive matrix protein 2 / type: protein_or_peptide / ID: 34 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 300.255312 KDa

Sequence

String:

MYNGIGLPTP RGSGTNGYVQ RNLSLVRGRR GERPDYKGEE ELRRLEAALV KRPNPDILDH ERKRRVELRC LELEEMMEEQ GYEEQQIQE KVATFRLMLL EKDVNPGGKE ETPGQRPAVT ETHQLAELNE KKNERLRAAF GISDSYVDGS SFDPQRRARE A KQPAPEPP KPYSLVRESS SSRSPTPKQK KKKKKKDRGR RSESSSPRRE RKKSSKKKKH RSESESKKRK HRSPTPKSKR KS KDKKRKR SRSTTPAPKS RRAHRSTSAD SASSSDTSRS RSRSAAAKTH TTALAGRSPS PASGRRGEGD APFSEPGTTS TQR PSSPET ATKQPSSPYE DKDKDKKEKS ATRPSPSPER SSTGPEPPAP TPLLAERHGG SPQPLATTPL SQEPVNPPSE ASPT RDRSP PKSPEKLPQS SSSESSPPSP QPTKVSRHAS SSPESPKPAP APGSHREISS SPTSKNRSHG RAKRDKSHSH TPSRR MGRS RSPATAKRGR SRSRTPTKRG HSRSRSPQWR RSRSAQRWGR SRSPQRRGRS RSPQRPGWSR SRNTQRRGRS RSARRG RSH SRSPATRGRS RSRTPARRGR SRSRTPARRR SRSRTPTRRR SRSRTPARRG RSRSRTPARR RSRTRSPVRR RSRSRSP AR RSGRSRSRTP ARRGRSRSRT PARRGRSRSR TPARRSGRSR SRTPARRGRS RSRTPRRGRS RSRSLVRRGR SHSRTPQR R GRSGSSSERK NKSRTSQRRS RSNSSPEMKK SRISSRRSRS LSSPRSKAKS RLSLRRSLSG SSPCPKQKSQ TPPRRSRSG SSQPKAKSRT PPRRSRSSSS PPPKQKSKTP SRQSHSSSSP HPKVKSGTPP RQGSITSPQA NEQSVTPQRR SCFESSPDPE LKSRTPSRH SCSGSSPPRV KSSTPPRQSP SRSSSPQPKV KAIISPRQRS HSGSSSPSPS RVTSRTTPRR SRSVSPCSNV E SRLLPRYS HSGSSSPDTK VKPETPPRQS HSGSISPYPK VKAQTPPGPS LSGSKSPCPQ EKSKDSLVQS CPGSLSLCAG VK SSTPPGE SYFGVSSLQL KGQSQTSPDH RSDTSSPEVR QSHSESPSLQ SKSQTSPKGG RSRSSSPVTE LASRSPIRQD RGE FSASPM LKSGMSPEQS RFQSDSSSYP TVDSNSLLGQ SRLETAESKE KMALPPQEDA TASPPRQKDK FSPFPVQDRP ESSL VFKDT LRTPPRERSG AGSSPETKEQ NSALPTSSQD EELMEVVEKS EEPAGQILSH LSSELKEMST SNFESSPEVE ERPAV SLTL DQSQSQASLE AVEVPSMASS WGGPHFSPEH KELSNSPLRE NSFGSPLEFR NSGPLGTEMN TGFSSEVKED LNGPFL NQL ETDPSLDMKE QSTRSSGHSS SELSPDAVEK AGMSSNQSIS SPVLDAVPRT PSRERSSSAS SPEMKDGLPR TPSRRSR SG SSPGLRDGSG TPSRHSLSGS SPGMKDIPRT PSRGRSECDS SPEPKALPQT PRPRSRSPSS PELNNKCLTP QRERSGSE S SVDQKTVART PLGQRSRSGS SQELDVKPSA SPQERSESDS SPDSKAKTRT PLRQRSRSGS SPEVDSKSRL SPRRSRSGS SPEVKDKPRA APRAQSGSDS SPEPKAPAPR ALPRRSRSGS SSKGRGPSPE GSSSTESSPE HPPKSRTARR GSRSSPEPKT KSRTPPRRR SSRSSPELTR KARLSRRSRS ASSSPETRSR TPPRHRRSPS VSSPEPAEKS RSSRRRRSAS SPRTKTTSRR G RSPSPKPR GLQRSRSRSR REKTRTTRRR DRSGSSQSTS RRRQRSRSRS RVTRRRRGGS GYHSRSPARQ ESSRTSSRRR RG RSRTPPT SRKRSRSRTS PAPWKRSRSR ASPATHRRSR SRTPLISRRR SRSRTSPVSR RRSRSRTSVT RRRSRSRASP VSR RRSRSR TPPVTRRRSR SRTPTTRRRS RSRTPPVTRR RSRSRTPPVT RRRSRSRTSP ITRRRSRSRT SPVTRRRSRS RTSP VTRRR SRSRTSPVTR RRSRSRTPPA IRRRSRSRTP LLPRKRSRSR SPLAIRRRSR SRTPRTARGK RSLTRSPPAI RRRSA SGSS SDRSRSATPP ATRNHSGSRT PPVALNSSRM SCFSRPSMSP TPLDRCRSPG MLEPLGSSRT PMSVLQQAGG SMMDGP GPR IPDHQRTSVP ENHAQSRIAL ALTAISLGTA RPPPSMSAAG LAARMSQVPA PVPLMSLRTA PAANLASRIP AASAAAM NL ASARTPAIPT AVNLADSRTP AAAAAMNLAS PRTAVAPSAV NLADPRTPTA PAVNLAGART PAALAALSLT GSGTPPTA A NYPSSSRTPQ APASANLVGP RSAHATAPVN IAGSRTAAAL APASLTSARM APALSGANLT SPRVPLSAYE RVSGRTSPP LLDRARSRTP PSAPSQSRMT SERAPSPSSR MGQAPSQSLL PPAQDQPRSP VPSAFSDQSR CLIAQTTPVA GSQSLSSGAV ATTTSSAGD HNGMLSVPAP GVPHSDVGEP PASTGAQQPS ALAALQPAKE RRSSSSSSSS SSSSSSSSSS SSSSSSSGSS S SDSEGSSL PVQPEVALKR VPSPTPAPKE AVREGRPPEP TPAKRKRRSS SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS SS SSSSSSS SPSPAKPGPQ ALPKPASPKK PPPGERRSRS PRKPIDSLRD SRSLSYSPVE RRRPSPQPSP RDQQSSSSER GSR RGQRGD SRSPSHKRRR ETPSPRPMRH RSSRSP

UniProtKB: Serine/arginine repetitive matrix protein 2

Macromolecule #35: Pre-mRNA-splicing factor CWC22 homolog

• Macromolecule: Name: Pre-mRNA-splicing factor CWC22 homolog / type: protein_or_peptide / ID: 35 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 105.646578 KDa

Sequence

String:

MKSSVAQIKP SSGHDRRENL NSYQRNSSPE DRYEEQERSP RDRDYFDYSR SDYEHSRRGR SYDSSMESRN RDREKRRERE RDTDRKRSR KSPSPGRRNP ETSVTQSSSA QDEPATKKKK DELDPLLTRT GGAYIPPAKL RMMQEQITDK NSLAYQRMSW E ALKKSING LINKVNISNI SIIIQELLQE NIVRGRGLLS RSVLQAQSAS PIFTHVYAAL VAIINSKFPQ IGELILKRLI LN FRKGYRR NDKQLCLTAS KFVAHLINQN VAHEVLCLEM LTLLLERPTD DSVEVAIGFL KECGLKLTQV SPRGINAIFE RLR NILHES EIDKRVQYMI EVMFAVRKDG FKDHPIILEG LDLVEEDDQF THMLPLEDDY NPEDVLNVFK MDPNFMENEE KYKA IKKEI LDEGDTDSNT DQDAGSSEED EEEEEEEGEE DEEGQKVTIH DKTEINLVSF RRTIYLAIQS SLDFEECAHK LLKME FPES QTKELCNMIL DCCAQQRTYE KFFGLLAGRF CMLKKEYMES FEGIFKEQYD TIHRLETNKL RNVAKMFAHL LYTDSL PWS VLECIKLSEE TTTSSSRIFV KIFFQELCEY MGLPKLNARL KDETLQPFFE GLLPRDNPRN TRFAINFFTS IGLGGLT DE LREHLKNTPK VIVAQKPDVE QNKSSPSSSS SASSSSESDS SDSDSDSSDS SSESSSEESD SSSISSHSSA SANDVRKK G HGKTRSKEVD KLIRNQQTND RKQKERRQEH GHQETRTERE RRSEKHRDQN SSGSNWRDPI TKYTSDKDVP SERNNYSRV ANDRDQEMHI DLENKHGDPK KKRGERRNSF SENEKHTHRI KDSENFRRKD RSKSKEMNRK HSGSRSDEDR YQNGAERRWE KSSRYSEQS RESKKNQDRR REKSPAKQK

UniProtKB: Pre-mRNA-splicing factor CWC22 homolog

Macromolecule #36: WD repeat-containing protein 25

• Macromolecule: Name: WD repeat-containing protein 25 / type: protein_or_peptide / ID: 36 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 60.245027 KDa

Sequence

String:

MTARTLSLMA SLVAYDDSDS EAETEHAGSF NATGQQKDTS GVARPPGQDF ASGTLDVPKA GAQPTKHGSC EDPGGYRLPL AQLGRSDWG SCPSQRLQWP GKEPQVTFPI KEPSCSSLWT SHVPASHMPL AAARFKQVKL SRNFPKSSFH AQSESETVGK N GSSFQKKK CEDCVVPYTP RRLRQRQALS TETGKGKDVE PQGPPAGRAP APLYVGPGVS EFIQPYLNSH YKETTVPRKV LF HLRGHRG PVNTIQWCPV LSKSHMLLST SMDKTFKVWN AVDSGHCLQT YSLHTEAVRA ARWAPCGRRI LSGGFDFALH LTD LETGTQ LFSGRSDFRI TTLKFHPKDH NIFLCGGFSS EMKAWDIRTG KVMRSYKATI QQTLDILFLR EGSEFLSSTD ASTR DSADR TIIAWDFRTS AKISNQIFHE RFTCPSLALH PREPVFLAQT NGNYLALFST VWPYRMSRRR RYEGHKVEGY SVGCE CSPG GDLLVTGSAD GRVLMYSFRT ASRACTLQGH TQACVGTTYH PVLPSVLATC SWGGDMKIWH

UniProtKB: WD repeat-containing protein 25

Macromolecule #37: Splicing factor Cactin

• Macromolecule: Name: Splicing factor Cactin / type: protein_or_peptide / ID: 37 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 88.860062 KDa

Sequence

String:

MGRDTRSRSR SAGRRGRRRQ SQSGSRSRSR SHGRRNRRRR EDEGRRRRRR RSRERRSDSE EERWQRSGMR SRSPPRPKWH SRDGSSQSD SGEEQSRGQW ARRRRRARSW SPSSSASSSA SPGRSQSPRA AAAALSQQQS LQERLRLREE RKQQEELMKA F ETPEEKRA RRLAKKEAKE RKKREKMGWG EEYMGYTNTD NPFGDNNLLG TFIWNKALEK KGISHLEEKE LKERNKRIQE DN RLELQKV KQLRLERERE KAMREQELEM LQREKEAEHF KTWEEQEDNF HLQQAKLRSK IRIRDGRAKP IDLLAKYISA EDD DLAVEM HEPYTFLNGL TVADMEDLLE DIQVYMELEQ GKNADFWRDM TTITEDEISK LRKLEASGKG PGERREGVNA SVSS DVQSV FKGKTYNQLQ VIFQGIEGKI RAGGPNLDMG YWESLLQQLR AHMARARLRE RHQDVLRQKL YKLKQEQGVE SEPLF PILK QEPQSPSRSL EPEDAAPTPP GPSSEGGPAE AEVDGATPTE GDGDGDGEGE GEGEAVLMEE DLIQQSLDDY DAGRYS PRL LTAHELPLDA HVLEPDEDLQ RLQLSRQQLQ VTGDASESAE DIFFRRAKEG MGQDEAQFSV EMPLTGKAYL WADKYRP RK PRFFNRVHTG FEWNKYNQTH YDFDNPPPKI VQGYKFNIFY PDLIDKRSTP EYFLEACADN KDFAILRFHA GPPYEDIA F KIVNREWEYS HRHGFRCQFA NGIFQLWFHF KRYRYRR

UniProtKB: Splicing factor Cactin

Macromolecule #38: Protein FAM32A

• Macromolecule: Name: Protein FAM32A / type: protein_or_peptide / ID: 38 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 13.213453 KDa

Sequence

String:

MEAYEQVQKG PLKLKGVAEL GVTKRKKKKK DKDKAKLLEA MGTSKKNEEE KRRGLDKRTP AQAAFEKMQE KRQMERILKK ASKTHKQRV EDFNRHLDTL TEHYDIPKVS WTK

UniProtKB: Protein FAM32A

Macromolecule #39: NF-kappa-B-activating protein

• Macromolecule: Name: NF-kappa-B-activating protein / type: protein_or_peptide / ID: 39 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 47.25266 KDa

Sequence

String:

MAPVSGSRSP DREASGSGGR RRSSSKSPKP SKSARSPRGR RSRSHSCSRS GDRNGLTHQL GGLSQGSRNQ SYRSRSRSRS RERPSAPRG IPFASASSSV YYGSYSRPYG SDKPWPSLLD KEREESLRQK RLSERERIGE LGAPEVWGLS PKNPEPDSDE H TPVEDEEP KKSTTSASTS EEEKKKKSSR SKERSKKRRK KKSSKRKHKK YSEDSDSDSD SETDSSDEDN KRRAKKAKKK EK KKKHRSK KYKKKRSKKS RKESSDSSSK ESQEEFLENP WKDRTKAEEP SDLIGPEAPK TLTSQDDKPL NYGHALLPGE GAA MAEYVK AGKRIPRRGE IGLTSEEIAS FECSGYVMSG SRHRRMEAVR LRKENQIYSA DEKRALASFN QEERRKRENK ILAS FREMV YRKTKGKDDK

UniProtKB: NF-kappa-B-activating protein

Macromolecule #40: Small nuclear ribonucleoprotein-associated proteins B and B'

• Macromolecule: Name: Small nuclear ribonucleoprotein-associated proteins B and B'; type: protein_or_peptide / ID: 40 / Number of copies: 2 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 24.642131 KDa

Sequence

String:

MTVGKSSKML QHIDYRMRCI LQDGRIFIGT FKAFDKHMNL ILCDCDEFRK IKPKNSKQAE REEKRVLGLV LLRGENLVSM TVEGPPPKD TGIARVPLAG AAGGPGIGRA AGRGIPAGVP MPQAPAGLAG PVRGVGGPSQ QVMTPQGRGT VAAAAAAATA S IAGAPTQY PPGRGGPPPP MGRGAPPPGM MGPPPGMRPP MGPPMGIPPG RGTPMGMPPP GMRPPPPGMR GPPPPGMRPP RP

UniProtKB: Small nuclear ribonucleoprotein-associated proteins B and B'

Macromolecule #41: Small nuclear ribonucleoprotein Sm D1

• Macromolecule: Name: Small nuclear ribonucleoprotein Sm D1 / type: protein_or_peptide / ID: 41 / Number of copies: 2 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 13.310653 KDa

Sequence

String:

MKLVRFLMKL SHETVTIELK NGTQVHGTIT GVDVSMNTHL KAVKMTLKNR EPVQLETLSI RGNNIRYFIL PDSLPLDTLL VDVEPKVKS KKREAVAGRG RGRGRGRGRG RGRGRGGPRR

UniProtKB: Small nuclear ribonucleoprotein Sm D1

Macromolecule #42: Small nuclear ribonucleoprotein Sm D2

• Macromolecule: Name: Small nuclear ribonucleoprotein Sm D2 / type: protein_or_peptide / ID: 42 / Number of copies: 2 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 13.551928 KDa

Sequence

String:

MSLLNKPKSE MTPEELQKRE EEEFNTGPLS VLTQSVKNNT QVLINCRNNK KLLGRVKAFD RHCNMVLENV KEMWTEVPKS GKGKKKSKP VNKDRYISKM FLRGDSVIVV LRNPLIAGK

UniProtKB: Small nuclear ribonucleoprotein Sm D2

Macromolecule #43: Small nuclear ribonucleoprotein Sm D3

• Macromolecule: Name: Small nuclear ribonucleoprotein Sm D3 / type: protein_or_peptide / ID: 43 / Number of copies: 2 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 13.940308 KDa

Sequence

String:

MSIGVPIKVL HEAEGHIVTC ETNTGEVYRG KLIEAEDNMN CQMSNITVTY RDGRVAQLEQ VYIRGSKIRF LILPDMLKNA PMLKSMKNK NQGSGAGRGK AAILKAQVAA RGRGRGMGRG NIFQKRR

UniProtKB: Small nuclear ribonucleoprotein Sm D3

Macromolecule #44: Small nuclear ribonucleoprotein E

• Macromolecule: Name: Small nuclear ribonucleoprotein E / type: protein_or_peptide / ID: 44 / Number of copies: 2 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 10.817601 KDa

Sequence

String:

MAYRGQGQKV QKVMVQPINL IFRYLQNRSR IQVWLYEQVN MRIEGCIIGF DEYMNLVLDD AEEIHSKTKS RKQLGRIMLK GDNITLLQS VSN

UniProtKB: Small nuclear ribonucleoprotein E

Macromolecule #45: Small nuclear ribonucleoprotein F

• Macromolecule: Name: Small nuclear ribonucleoprotein F / type: protein_or_peptide / ID: 45 / Number of copies: 2 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 9.734171 KDa

Sequence

String:

MSLPLNPKPF LNGLTGKPVM VKLKWGMEYK GYLVSVDGYM NMQLANTEEY IDGALSGHLG EVLIRCNNVL YIRGVEEEEE DGEMRE

UniProtKB: Small nuclear ribonucleoprotein F

Macromolecule #46: Small nuclear ribonucleoprotein G

• Macromolecule: Name: Small nuclear ribonucleoprotein G / type: protein_or_peptide / ID: 46 / Number of copies: 2 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 8.508084 KDa

Sequence

String:

MSKAHPPELK KFMDKKLSLK LNGGRHVQGI LRGFDPFMNL VIDECVEMAT SGQQNNIGMV VIRGNSIIML EALERV

UniProtKB: Small nuclear ribonucleoprotein G

Macromolecule #47: Splicing factor ESS-2 homolog

• Macromolecule: Name: Splicing factor ESS-2 homolog / type: protein_or_peptide / ID: 47 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 52.639953 KDa

Sequence

String:

METPGASASS LLLPAASRPP RKREAGEAGA ATSKQRVLDE EEYIEGLQTV IQRDFFPDVE KLQAQKEYLE AEENGDLERM RQIAIKFGS ALGKMSREPP PPYVTPATFE TPEVHAGTGV VGNKPRPRGR GLEDGEAGEE EEKEPLPSLD VFLSRYTSED N ASFQEIME VAKERSRARH AWLYQAEEEF EKRQKDNLEL PSAEHQAIES SQASVETWKY KAKNSLMYYP EGVPDEEQLF KK PRQVVHK NTRFLRDPFS QALSRCQLQQ AAALNAQHKQ GKVGPDGKEL IPQESPRVGG FGFVATPSPA PGVNESPMMT WGE VENTPL RVEGSETPYV DRTPGPAFKI LEPGRRERLG LKMANEAAAK NRAKKQEALR RVTENLASLT PKGLSPAMSP ALQR LVSRT ASKYTDRALR ASYTPSPARS THLKTPASGL QTPTSTPAPG SATRTPLTQD PASITDNLLQ LPARRKASDF F

UniProtKB: Splicing factor ESS-2 homolog

Macromolecule #48: Pre-mRNA-processing factor 19

• Macromolecule: Name: Pre-mRNA-processing factor 19 / type: protein_or_peptide / ID: 48 / Number of copies: 4 / Enantiomer: LEVO / EC number: RING-type E3 ubiquitin transferase
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 55.245547 KDa

Sequence

String:

MSLICSISNE VPEHPCVSPV SNHVYERRLI EKYIAENGTD PINNQPLSEE QLIDIKVAHP IRPKPPSATS IPAILKALQD EWDAVMLHS FTLRQQLQTT RQELSHALYQ HDAACRVIAR LTKEVTAARE ALATLKPQAG LIVPQAVPSS QPSVVGAGEP M DLGELVGM TPEIIQKLQD KATVLTTERK KRGKTVPEEL VKPEELSKYR QVASHVGLHS ASIPGILALD LCPSDTNKIL TG GADKNVV VFDKSSEQIL ATLKGHTKKV TSVVFHPSQD LVFSASPDAT IRIWSVPNAS CVQVVRAHES AVTGLSLHAT GDY LLSSSD DQYWAFSDIQ TGRVLTKVTD ETSGCSLTCA QFHPDGLIFG TGTMDSQIKI WDLKERTNVA NFPGHSGPIT SIAF SENGY YLATAADDSS VKLWDLRKLK NFKTLQLDNN FEVKSLIFDQ SGTYLALGGT DVQIYICKQW TEILHFTEHS GLTTG VAFG HHAKFIASTG MDRSLKFYSL

UniProtKB: Pre-mRNA-processing factor 19

Macromolecule #49: Pre-mRNA-splicing factor SPF27

• Macromolecule: Name: Pre-mRNA-splicing factor SPF27 / type: protein_or_peptide / ID: 49 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 26.16342 KDa

Sequence

String:

MAGTGLVAGE VVVDALPYFD QGYEAPGVRE AAAALVEEET RRYRPTKNYL SYLTAPDYSA FETDIMRNEF ERLAARQPIE LLSMKRYEL PAPSSGQKND ITAWQECVNN SMAQLEHQAV RIENLELMSQ HGCNAWKVYN ENLVHMIEHA QKELQKLRKH I QDLNWQRK NMQLTAGSKL REMESNWVSL VSKNYEIERT IVQLENEIYQ IKQQHGEANK ENIRQDF

UniProtKB: Pre-mRNA-splicing factor SPF27

Macromolecule #50: Eukaryotic initiation factor 4A-III

• Macromolecule: Name: Eukaryotic initiation factor 4A-III / type: protein_or_peptide / ID: 50 / Number of copies: 1 / Enantiomer: LEVO / EC number: RNA helicase
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 46.930961 KDa

Sequence

String:

MATTATMATS GSARKRLLKE EDMTKVEFET SEEVDVTPTF DTMGLREDLL RGIYAYGFEK PSAIQQRAIK QIIKGRDVIA QSQSGTGKT ATFSISVLQC LDIQVRETQA LILAPTRELA VQIQKGLLAL GDYMNVQCHA CIGGTNVGED IRKLDYGQHV V AGTPGRVF DMIRRRSLRT RAIKMLVLDE ADEMLNKGFK EQIYDVYRYL PPATQVVLIS ATLPHEILEM TNKFMTDPIR IL VKRDELT LEGIKQFFVA VEREEWKFDT LCDLYDTLTI TQAVIFCNTK RKVDWLTEKM REANFTVSSM HGDMPQKERE SIM KEFRSG ASRVLISTDV WARGLDVPQV SLIINYDLPN NRELYIHRIG RSGRYGRKGV AINFVKNDDI RILRDIEQYY STQI DEMPM NVADLI

UniProtKB: Eukaryotic initiation factor 4A-III

Macromolecule #51: Protein mago nashi homolog

• Macromolecule: Name: Protein mago nashi homolog / type: protein_or_peptide / ID: 51 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 17.189625 KDa

Sequence

String:

MESDFYLRYY VGHKGKFGHE FLEFEFRPDG KLRYANNSNY KNDVMIRKEA YVHKSVMEEL KRIIDDSEIT KEDDALWPPP DRVGRQELE IVIGDEHISF TTSKIGSLID VNQSKDPEGL RVFYYLVQDL KCLVFSLIGL HFKIKPI

UniProtKB: Protein mago nashi homolog

Macromolecule #52: RNA-binding protein 8A

• Macromolecule: Name: RNA-binding protein 8A / type: protein_or_peptide / ID: 52 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 19.92507 KDa

Sequence

String:

MADVLDLHEA GGEDFAMDED GDESIHKLKE KAKKRKGRGF GSEEGSRARM REDYDSVEQD GDEPGPQRSV EGWILFVTGV HEEATEEDI HDKFAEYGEI KNIHLNLDRR TGYLKGYTLV EYETYKEAQA AMEGLNGQDL MGQPISVDWC FVRGPPKGKR R GGRRRSRS PDRRRR

UniProtKB: RNA-binding protein 8A

Macromolecule #53: RNA-binding protein 41

• Macromolecule: Name: RNA-binding protein 41 / type: protein_or_peptide / ID: 53 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 47.169781 KDa

Sequence

String:

MKRVNSCVKS DEHVLEELET EGERQLKSLL QHQLDTSVSI EECMSKKESF APGTMYKPFG KEAAGTMTLS QFQTLHEKDQ ETASLRELG LNETEILIWK SHVSGEKKTK LRATPEAIQN RLQDIEERIS ERQRILCLPQ RFAKSKQLTR REMEIEKSLF Q GADRHSFL KALYYQDEPQ KKNKGDPMNN LESFYQEMIM KKRLEEFQLM RGEPFASHSL VSATSVGDSG TAESPSLLQD KG KQAAQGK GPSLHVANVI DFSPEQCWTG PKKLTQPIEF VPEDEIQRNR LSEEEIRKIP MFSSYNPGEP NKVLYLKNLS PRV TERDLV SLFARFQEKK GPPIQFRMMT GRMRGQAFIT FPNKEIAWQA LHLVNGYKLH GKILVIEFGK NKKQRSNLQA TSLI SCATG STTEISGS

UniProtKB: RNA-binding protein 41

Macromolecule #54: Protein FAM204A

• Macromolecule: Name: Protein FAM204A / type: protein_or_peptide / ID: 54 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 27.070291 KDa

Sequence

String:

MWSGLLPPGL NESDAESNSE DEATLENSGL NLQEDKEDES IRKTEIIDFS TDEPKTETES NVNAYEECPS GIPIDMWNKF QELHKKHSE QKSTTSRFRG KRRKRSRKDK LKNEKELHSE PSSNETQWKE LTQYFGVNDR FDPPVKRKKV EKSGLEKRID Q AVEEWNIE KAEELSNQLA TRELGVKIAK AVACHNFVKA KKEVENSQAA RKKKKLAWGF EAKKRWETKS NMGYM

UniProtKB: Protein FAM204A

Macromolecule #55: MAGNESIUM ION

• Macromolecule: Name: MAGNESIUM ION / type: ligand / ID: 55 / Number of copies: 9 / Formula: MG
• Molecular weight: Theoretical: 24.305 Da

Macromolecule #56: POTASSIUM ION

• Macromolecule: Name: POTASSIUM ION / type: ligand / ID: 56 / Number of copies: 2 / Formula: K
• Molecular weight: Theoretical: 39.098 Da

Macromolecule #57: INOSITOL HEXAKISPHOSPHATE

• Macromolecule: Name: INOSITOL HEXAKISPHOSPHATE / type: ligand / ID: 57 / Number of copies: 1 / Formula: IHP
• Molecular weight: Theoretical: 660.035 Da

Chemical component information

ChemComp-IHP:
INOSITOL HEXAKISPHOSPHATE

Macromolecule #58: GUANOSINE-5'-TRIPHOSPHATE

• Macromolecule: Name: GUANOSINE-5'-TRIPHOSPHATE / type: ligand / ID: 58 / Number of copies: 1 / Formula: GTP
• Molecular weight: Theoretical: 523.18 Da

Chemical component information

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

Macromolecule #59: ADENOSINE-5'-DIPHOSPHATE

• Macromolecule: Name: ADENOSINE-5'-DIPHOSPHATE / type: ligand / ID: 59 / Number of copies: 2 / Formula: ADP
• Molecular weight: Theoretical: 427.201 Da

Chemical component information

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

Macromolecule #60: ZINC ION

• Macromolecule: Name: ZINC ION / type: ligand / ID: 60 / Number of copies: 1 / Formula: ZN
• Molecular weight: Theoretical: 65.409 Da

Macromolecule #61: ADENOSINE-5'-TRIPHOSPHATE

• Macromolecule: Name: ADENOSINE-5'-TRIPHOSPHATE / type: ligand / ID: 61 / Number of copies: 1 / Formula: ATP
• Molecular weight: Theoretical: 507.181 Da

Chemical component information

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

Macromolecule #62: water

• Macromolecule: Name: water / type: ligand / ID: 62 / Number of copies: 1 / Formula: HOH
• Molecular weight: Theoretical: 18.015 Da

Chemical component information

ChemComp-HOH:
WATER

Experimental details

Structure determination

• Method: cryo EM
• Processing: single particle reconstruction
• Aggregation state: particle

Sample preparation

• Buffer: pH: 7.9
• Vitrification: Cryogen name: NITROGEN

Electron microscopy

• Microscope: TFS KRIOS
• Image recording: Film or detector model: GATAN K3 (6k x 4k) / Average electron dose: 50.0 e/Ų
• Electron beam: Acceleration voltage: 300 kV / Electron source: FIELD EMISSION GUN
• Electron optics: Illumination mode: FLOOD BEAM / Imaging mode: BRIGHT FIELD / Nominal defocus max: 1.9000000000000001 µm / Nominal defocus min: 1.3 µm
• Experimental equipment: Model: Titan Krios / Image courtesy: FEI Company

Image processing

• CTF correction: Type: PHASE FLIPPING AND AMPLITUDE CORRECTION

Startup model

Type of model: EMDB MAP
EMDB ID:

6721

• Final reconstruction: Resolution.type: BY AUTHOR / Resolution: 3.0 Å / Resolution method: FSC 0.143 CUT-OFF / Software - Name: cryoSPARC / Number images used: 145908
• Initial angle assignment: Type: MAXIMUM LIKELIHOOD
• Final angle assignment: Type: MAXIMUM LIKELIHOOD