登録情報 | データベース: EMDB / ID: EMD-60254 |
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タイトル | Vesamicol-bound VAChT |
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マップデータ | |
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試料 | - 複合体: VAChT
- タンパク質・ペプチド: Maltose/maltodextrin-binding periplasmic protein,Vesicular acetylcholine transporter,DARPinoff7
- リガンド: vesamicol
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キーワード | VAChT / SLC18A3 / Vesamicol / Acetylcholine / TRANSPORT PROTEIN |
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機能・相同性 | 機能・相同性情報
acetylcholine:proton antiporter activity / acetylcholine uptake / positive regulation of neuromuscular junction development / clathrin-sculpted acetylcholine transport vesicle membrane / acetylcholine transmembrane transporter activity / monoamine:proton antiporter activity / AP-1 adaptor complex / Acetylcholine Neurotransmitter Release Cycle / positive regulation of acetylcholine secretion, neurotransmission / AP-2 adaptor complex ...acetylcholine:proton antiporter activity / acetylcholine uptake / positive regulation of neuromuscular junction development / clathrin-sculpted acetylcholine transport vesicle membrane / acetylcholine transmembrane transporter activity / monoamine:proton antiporter activity / AP-1 adaptor complex / Acetylcholine Neurotransmitter Release Cycle / positive regulation of acetylcholine secretion, neurotransmission / AP-2 adaptor complex / serotonin uptake / neurotransmitter transport / detection of maltose stimulus / maltose transport complex / carbohydrate transport / carbohydrate transmembrane transporter activity / maltose binding / maltose transport / maltodextrin transmembrane transport / ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing / ATP-binding cassette (ABC) transporter complex / cell chemotaxis / positive regulation of long-term synaptic potentiation / clathrin-coated endocytic vesicle membrane / terminal bouton / synaptic vesicle membrane / Cargo recognition for clathrin-mediated endocytosis / Clathrin-mediated endocytosis / outer membrane-bounded periplasmic space / chemical synaptic transmission / periplasmic space / DNA damage response / membrane / plasma membrane類似検索 - 分子機能 Major facilitator superfamily / Major Facilitator Superfamily / Major facilitator superfamily domain / Major facilitator superfamily (MFS) profile. / MFS transporter superfamily / Maltose/Cyclodextrin ABC transporter, substrate-binding protein / Solute-binding family 1, conserved site / Bacterial extracellular solute-binding proteins, family 1 signature. / Bacterial extracellular solute-binding protein / Bacterial extracellular solute-binding protein類似検索 - ドメイン・相同性 Maltose/maltodextrin-binding periplasmic protein / Vesicular acetylcholine transporter類似検索 - 構成要素 |
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生物種 | ![](img/tx_bacteria.gif) Escherichia coli (strain K12) (大腸菌) / synthetic construct (人工物) |
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手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.5 Å |
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データ登録者 | Zhang Z / Zhang Y / Dai F / Zhang YX / Lee C-H |
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資金援助 | 中国, 1件 Organization | Grant number | 国 |
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National Science Foundation (NSF, China) | | 中国 |
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引用 | ジャーナル: Cell Res / 年: 2024 タイトル: Structural insights into VAChT neurotransmitter recognition and inhibition. 著者: Yang Zhang / Fei Dai / Nanhao Chen / Dong Zhou / Chia-Hsueh Lee / Chen Song / Yixiao Zhang / Zhe Zhang / ![](img/flg_usa.gif) |
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履歴 | 登録 | 2024年5月23日 | - |
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ヘッダ(付随情報) 公開 | 2024年6月19日 | - |
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マップ公開 | 2024年6月19日 | - |
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更新 | 2024年6月19日 | - |
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現状 | 2024年6月19日 | 処理サイト: PDBj / 状態: 公開 |
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