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Structure paper

TitleStructural insights into VAChT neurotransmitter recognition and inhibition.
Journal, issue, pagesCell Res, Vol. 34, Issue 9, Page 665-668, Year 2024
Publish dateJun 11, 2024
AuthorsYang Zhang / Fei Dai / Nanhao Chen / Dong Zhou / Chia-Hsueh Lee / Chen Song / Yixiao Zhang / Zhe Zhang /
External linksCell Res / PubMed:38862671 / PubMed Central
MethodsEM (single particle)
Resolution3.5 - 3.7 Å
Structure data

60254

8zmr

EMDB-60254, PDB-8zmr:
Vesamicol-bound VAChT
Method: EM (single particle) / Resolution: 3.5 Å

60255

8zms

EMDB-60255, PDB-8zms:
Acetylcholine-bound VAChT
Method: EM (single particle) / Resolution: 3.7 Å

Chemicals

PDB-1lwl:
Crystal Structure of Cytochrome P450-cam with a Fluorescent Probe D-8-Ad (Adamantane-1-carboxylic acid-5-dimethylamino-naphthalene-1-sulfonylamino-octyl-amide)

ChemComp-ACH:
ACETYLCHOLINE / neurotransmitter*YM

Source
  • escherichia coli (strain k12) (bacteria)
  • synthetic construct (others)
  • homo sapiens (human)
KeywordsTRANSPORT PROTEIN / VAChT / SLC18A3 / Vesamicol / Acetylcholine

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