90S preribosome / rough endoplasmic reticulum / positive regulation of apoptotic signaling pathway / maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / cytosolic ribosome / maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / small-subunit processome / rRNA processing / structural constituent of chromatin / nucleosome ...90S preribosome / rough endoplasmic reticulum / positive regulation of apoptotic signaling pathway / maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / cytosolic ribosome / maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / small-subunit processome / rRNA processing / structural constituent of chromatin / nucleosome / nucleosome assembly / ribosome biogenesis / ribosomal small subunit biogenesis / small ribosomal subunit / cytosolic small ribosomal subunit / large ribosomal subunit rRNA binding / cytosolic large ribosomal subunit / cytoplasmic translation / rRNA binding / structural constituent of ribosome / ribosome / translation / ribonucleoprotein complex / mRNA binding / DNA binding / RNA binding / nucleus / cytosol / cytoplasm Similarity search - Function
: / Linker histone H1/H5 / Ribosomal protein L30e / metallochaperone-like domain / TRASH domain / Ribosomal protein L22e / Ribosomal protein L22e superfamily / Ribosomal L22e protein family / Ribosomal protein S21e / Ribosomal protein S21e superfamily ...: / Linker histone H1/H5 / Ribosomal protein L30e / metallochaperone-like domain / TRASH domain / Ribosomal protein L22e / Ribosomal protein L22e superfamily / Ribosomal L22e protein family / Ribosomal protein S21e / Ribosomal protein S21e superfamily / Ribosomal protein S21e / Ribosomal protein L19, eukaryotic / 60S ribosomal protein L18a/ L20, eukaryotes / Ribosomal protein L19/L19e conserved site / Ribosomal protein L19e signature. / Ribosomal protein L34e, conserved site / Ribosomal protein L34e signature. / Ribosomal protein S30 / Ribosomal protein S30 / Ribosomal protein L30e signature 1. / Ribosomal protein S25 / S25 ribosomal protein / 50S ribosomal protein L18Ae/60S ribosomal protein L20 and L18a / Ribosomal protein L35Ae, conserved site / Ribosomal protein L35Ae signature. / Ribosomal protein 50S-L18Ae/60S-L20/60S-L18A / Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A / : / : / Ribosomal protein S7e signature. / Ribosomal protein S17e, conserved site / Ribosomal protein S17e signature. / Ribosomal protein L7A/L8 / Ribosomal protein L30e signature 2. / Ribosomal protein L30e, conserved site / Ribosomal protein L7, eukaryotic / : / Ribosomal protein L30, N-terminal / Ribosomal L30 N-terminal domain / Ribosomal protein L34Ae / Ribosomal protein L34e / Ribosomal protein S3, eukaryotic/archaeal / Ribosomal protein L30/YlxQ / 60S ribosomal protein L19 / 40S ribosomal protein S4, C-terminal domain / 40S ribosomal protein S4 C-terminus / : / Ribosomal protein L35A / Ribosomal protein L35Ae / Ribosomal protein S4e, N-terminal, conserved site / Ribosomal protein S4e signature. / Ribosomal protein L35A superfamily / Ribosomal protein S17e / Ribosomal protein S17e-like superfamily / Ribosomal S17 / : / : / Ribosomal protein L19e, C-terminal domain / Ribosomal_L19e / Ribosomal protein L19/L19e / Ribosomal protein L19/L19e, domain 1 / Ribosomal protein L19/L19e superfamily / Ribosomal protein L19e, N-terminal domain / Ribosomal protein L32e, conserved site / Ribosomal protein L32e signature. / 40S ribosomal protein S11, N-terminal / Ribosomal_S17 N-terminal / Ribosomal protein S7e / Ribosomal protein S7e / : / Ribosomal S24e conserved site / Ribosomal protein S24e signature. / Ribosomal protein S4e, N-terminal / RS4NT (NUC023) domain / Ribosomal protein S4, KOW domain / Ribosomal protein S4e / Ribosomal protein S4e, central region / Ribosomal protein S4e, central domain superfamily / Ribosomal family S4e / Ribosomal protein S17, archaeal/eukaryotic / Ribosomal protein S23, eukaryotic/archaeal / Ribosomal protein S8e / Ribosomal protein S24e / Ribosomal protein S24e / Ribosomal protein L24e-related / Ribosomal protein L24e/L24 superfamily / Ribosomal protein L24e / Ribosomal protein L7Ae conserved site / Ribosomal protein L7Ae signature. / Ribosomal protein S5/S7, eukaryotic/archaeal / Ribosomal protein L32e / Ribosomal protein L32e superfamily / Ribosomal protein L32 / Ribosomal_L32e / Ribosomal protein L7, eukaryotic/archaeal / Ribosomal protein L7/L30 / Ribosomal protein S4/S9, eukaryotic/archaeal / Ribosomal protein S8e/ribosomal biogenesis NSA2 / Ribosomal protein S8e / Ribosomal protein L7Ae/L8/Nhp2 family Similarity search - Domain/homology
: / : / : / : / : / : / : / : / : / : ...: / : / : / : / : / : / : / : / : / : / : / : / : / : / : / : / : / : / : / : / : / : / : / : / : / : / : / : / : / : / : / : / : / : / : / : / : / : / : / : / : / : / 40S ribosomal protein S8 / 60S ribosomal protein L11 / 60S ribosomal protein L18a / Uncharacterized protein LOC115210796 / Ribosomal protein L19 / Large ribosomal subunit protein eL34 / 40S ribosomal protein S25 / 40S ribosomal protein S24 / Large ribosomal subunit protein uL14 / Small ribosomal subunit protein uS13 / 40S ribosomal protein S15a / Small ribosomal subunit protein uS9 / Large ribosomal subunit protein uL30 / Large ribosomal subunit protein eL30 / 40S ribosomal protein S21 / Small ribosomal subunit protein uS12 / Small ribosomal subunit protein eS17 / 60S ribosomal protein L32 / Large ribosomal subunit protein eL24 / Large ribosomal subunit protein eL22 / 60S ribosomal protein L7a / 40S ribosomal protein S4 / 40S ribosomal protein S3 / Ribosomal S5 / 40S ribosomal protein S14a / Large ribosomal subunit protein eL33 / 40S ribosomal protein S7 / Small ribosomal subunit protein uS17 / Small ribosomal subunit protein uS4 Similarity search - Component
Biological species
Octopus (invertebrata)
Method
single particle reconstruction / cryo EM / Resolution: 3.1 Å
Journal: bioRxiv / Year: 2026 Title: Evolution of a core ribosomal innovation in octopus. Authors: Rishav Mitra / Richard Han / Trey J Scott / Anik G Grearson / Jessica A Willi / Christina G Liu / Hyeongju Kim / Michael C Jewett / Nicholas W Bellono / Amy Sy Lee / Abstract: Much of biology focuses on how genetic changes mediate new functions, but less attention is given to adaptations in other steps of the central dogma. Octopuses exhibit complex nervous systems and ...Much of biology focuses on how genetic changes mediate new functions, but less attention is given to adaptations in other steps of the central dogma. Octopuses exhibit complex nervous systems and sophisticated behaviors that rival vertebrates, but via an entirely divergent evolutionary history. Here, we serendipitously discovered that octopus ribosomes contain a structural break in the core ribosomal RNA that is unique among all animals. This break site enhances translation fidelity to reduce miscoding and subsequent protein aggregation, even when engineered into evolutionarily distant bacterial ribosomes. Furthermore, high fidelity translation by octopus ribosomes supports proteomic stability during extensive RNA editing observed in cephalopods, suggesting synergy between distinct non-canonical modes of gene regulation. This adaptation emerged in recently derived octopuses with expanded nervous systems, thereby revealing a mechanism that could broadly support the evolution of novel organismal traits.
Macromolecule #16: Large ribosomal subunit protein eL43
Macromolecule
Name: Large ribosomal subunit protein eL43 / type: protein_or_peptide / ID: 16 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)
Organism: Octopus (invertebrata)
Molecular weight
Theoretical: 10.250259 KDa
Sequence
String:
MAKRTKKVGI CGKYGTRYGA SLRKTVKKME VSQHAKYTCK FCGKDAVKRK AVGIWSCKSC RKIVAGGAWS YSTTAAVTVR SAIRRLRDM KES
UniProtKB: UNIPROTKB: A0A0L8FTQ7
+
Macromolecule #17: Large ribosomal subunit protein uL4 C-terminal domain-containing ...
Macromolecule
Name: Large ribosomal subunit protein uL4 C-terminal domain-containing protein type: protein_or_peptide / ID: 17 / Number of copies: 1 / Enantiomer: LEVO
Macromolecule #18: Large ribosomal subunit protein uL18 C-terminal eukaryotes domain...
Macromolecule
Name: Large ribosomal subunit protein uL18 C-terminal eukaryotes domain-containing protein type: protein_or_peptide / ID: 18 / Number of copies: 1 / Enantiomer: LEVO
Macromolecule #33: Large ribosomal subunit protein uL23 N-terminal domain-containing...
Macromolecule
Name: Large ribosomal subunit protein uL23 N-terminal domain-containing protein type: protein_or_peptide / ID: 33 / Number of copies: 1 / Enantiomer: LEVO
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